KAKEN — Research Projects | Researcher Number: 90163906

1. The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	HARADA Tasuku Tottori University
Project Period (FY)	2008 – 2010Completed
Keywords	子宮内膜症 / アポトーシス / survivin / サイトカイン
Research Abstract	Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis. Endometriotic stromal cells showed re ...

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 18 results) Presentation (19 results) Remarks (2 results)

2. Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	TERAKAWA Naoki 鳥取大学, 名誉教授
Project Period (FY)	2008 – 2011Completed
Keywords	JEMS / 子宮内膜症 / がん化 / 疫学研究
Research Abstract	This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data colle ...

Research Products of this project	Journal Article (32 results, of which Peer Reviewed: 29 results) Presentation (45 results) Remarks (5 results)

3. Molecular basis of methylation-dependent expression of aromatase gene in endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	IZAWA Masao Tottori University
Project Period (FY)	2006 – 2008Completed
Keywords	子宮内膜症 / アロマターゼ遺伝子 / 遺伝子高発現 / エピジェネティクス制御異常 / CpGアイランド / DNA脱メチル化 / エストロゲン産生異常 / アポトーシス抵抗性 / 遺伝子発現異常 / PKC / アロマターゼ / エピジェネティクス
Research Abstract	「子宮内膜症細胞にアロマターゼ遺伝子高発現をもたらす分子基盤にはエピジェネティクス制御が関与する」との仮説の検証を通して、子宮内膜症の高濃度エストロゲン環境を生じる分子基盤の解明をめざした。本研究により、子宮内膜症細胞にけるアロマターゼ遺伝子高発現の分子基盤ををエピジェネティクス制御の観点より検証し ...

Research Products of this project	Journal Article (12 results, of which Peer Reviewed: 11 results) Presentation (13 results)

4. Adenovirus type 5 EIA gene therapy for ovarian carcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	ITAMOCHI Hiroaki Tottori University, Hospital, Associate Professor
Project Period (FY)	2005 – 2007Completed
Keywords	Carcinoma / Gene therapy / Chemoresponse
Research Abstract	Resistance of ovarian clear cell carcinoma (CCC) to platinum-based chemotherapy is associated with poor prognosis, and an effective treatment for adva ...

Research Products of this project	Journal Article (41 results, of which Peer Reviewed: 16 results) Presentation (48 results) Book (4 results)

5. Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	TERAKAWA Naoki Tottori University, Professor
Project Period (FY)	2005 – 2007Completed
Keywords	Endometrinsis / TNFα / IL-8 / dienogest / NFkB pathway / ovarian endometrioma / GnRH antagonist / Cetrorelix
Research Abstract	We previous reported that the proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-8 are elevated in the peritoneal f ...

Research Products of this project	Journal Article (33 results, of which Peer Reviewed: 16 results) Presentation (40 results)

6. Order made gene therapy for epithelial ovarian cancer on biological behavior

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	KIGAWA Junzou Tottori Univ., Faculty of Medicine, Associate Professor
Project Period (FY)	2004 – 2006Completed
Keywords	ovarian cancer / genetic diagnosis / gene therapy
Research Abstract	Gene therapy has been tried however, its success is limited in patients who develop chemoresistance a distinctly different clinical behavior. Many mec ...

Research Products of this project	Journal Article (17 results)

7. Development of drug treatment for endometriosis targeting cytokine signal transduction molecules

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	National University Corporation Tottori University
Principal Investigator	HARADA Tasuku Tottori University, Faculty of Medicine, Assistant Professor
Project Period (FY)	2004 – 2005Completed
Keywords	endometriosis / interleukin-8 / interleukin-6 / tumor necrosis factor alpha / NF-kB / progesterone / danazol / dienogest
Research Abstract	We previously showed that interleukin-8(IL-8) and tumor necrosis factor-a(TNFa) are significantly elevated in the PF of women with endometriosis compa ...

Research Products of this project	Journal Article (19 results)

8. Role of matrix met alloprot einases and cytokines in the development of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	TERAKAWA Naoki Tottori Univ., Dept.Obst et.Gynecol., Professor
Project Period (FY)	2002 – 2003Completed
Keywords	Endometriosis / Development and progression / Endometriotic stromal cells / Cytokine TNFα / IL-8 / Nuclear fact or-κB / Estrogen / GnRH agonist
Research Abstract	It is believed that the extracellular matrix (ECM) remodeling is relevant to the development and the progression of endometriosis. Tissue remodeling i ...

Research Products of this project	Publications (24 results)

9. Development of anti-cytokine drugs for treatment of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	HARADA Tasuku Tottori Univ., Dept.Obstet.Gunecol., Assistant Professor
Project Period (FY)	2001 – 2003Completed
Keywords	endometriosis / cytokine / interleukin-8 / tumor necrosis factor alpha / anti-TNF alpha antibody
Research Abstract	Peritoneal fluid (PF) in women with endometriosis contains an increased number of activated macrophages that secrete a variety of cytokines. We have p ...

Research Products of this project	Publications (39 results)

10. Gene therapy enhances chemotherapy induced apoptosis in a peritonitis carcinomatosa model with ovarian cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	KIGAWA Junzo Tottori Univ. Dept. Obstet. Gynecol., Associated Professor
Project Period (FY)	2000 – 2002Completed
Keywords	P53 gene / apoptosis / lperitonitis carcinomatosa model / gene therapy / ovarian cancer
Research Abstract	We found that mutations of the p53 gene newly occurred in 47% of patients after recurrence. Nonresponders to chemotherapy had mutations of the p53 gen ...

Research Products of this project	Publications (41 results)

11. Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B).
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	TERAKAWA Naoki Tottori Univ.Dept.Obstet.Gynecol., Professor
Project Period (FY)	1999 – 2000Completed
Keywords	Endometriosis / Pathogenesis / Infertility / Endometriotic stromal cells / Peritoneal macrophages / Cytokines / IL-6 / IL-8
Research Abstract	Endometriosis, which occurs in 10% of reproductive aged women, is characterized by the presence and growth of endometrial-like tissue outside the uter ...

Research Products of this project	Publications (11 results)

12. Role of cytokines in development of endometriosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	HARADA Tasuku Tottori Univ., Sch. of Med., Obstetrics and Gynecology, Associated Professor
Project Period (FY)	1998 – 1999Completed
Keywords	endometriosis / cytokine / MMP / TIMP / interleukin-6 / interleukin-10 / endometrium / IL-6 soluble receptor
Research Abstract	We have measured peritoneal fluid (PF) levels of matrix metalloproteinase-9 (MMP-9), its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1) a ...

Research Products of this project	Publications (24 results)

13. Chemoresistance and apoptotic pathway in ovarian cancer.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University School of Medicine
Principal Investigator	KANAMORI Yasunobu (1999-2000) Tottori Univ.Dept.Obstet.Gynecol., Research Associates 皆川幸久 (1998) 鳥取大学, 医学部, 講師
Project Period (FY)	1998 – 2000Completed
Keywords	Ovarian cancer / Apoptosis / Chemosensitivity / Cisplatin / p53
Research Abstract	1. The effect of p53 gene transduction to chemosensitivity.

Research Products of this project	Publications (25 results)

14. Telomerase activity and p53-induced apoptosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University
Principal Investigator	KIGAWA Junzo Tottori Univ. Sch. of Med., Obstetrics and Gynecology, Associated Professor
Project Period (FY)	1997 – 1999Completed
Keywords	telomerae / ovarian cancer apoptosis / p53 / gene-therapy / telomere
Research Abstract	Although p53 gene mutation is frequently seen in ovarian cancer, the function of p53 gene in chemosensitivity is not conclusively defined. First, we e ...

Research Products of this project	Publications (30 results)

15. Interleukin-8 is a possible angiogenic factor in endometrial cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University (School of Medicine)
Principal Investigator	TERAKAWA Naoki Tottori Univ.Dept.Obstet.Gynecol., Professor
Project Period (FY)	1996 – 1997Completed
Keywords	Endometrial cancer / Angiogenic factor / Tumor necrosis factor a / Interleukin-8 / Stromal cells / Microvessel density / Cancer growth / Paracrine effect
Research Abstract	This study was undertaken to find out the candidate of an angiogenic factor (s) in endometrial carcinoma. In recent clinical studies, we have found th ...

Research Products of this project	Publications (24 results)

16. Overcoming cisplatin-resistance in ovarian cancer through induction of apoptosis by anticancer agents

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University (School of Medicine)
Principal Investigator	MINAGAWA Yukihisa Tottori Univ.Dept.Obstet.Gynecol., Assistant Professor
Project Period (FY)	1995 – 1997Completed
Keywords	apoptosis / topoisomerase / cicplatin-resistance / ovarian cancer
Research Abstract	The aim of the present study was to clarify the relation between quantitative and/or qualitative changes of DNA topoisomerase (Topo) and the ability o ...

Research Products of this project	Publications (24 results)

17. p53-based gene therapy of ovarian cancer with chemo-resistance

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University, Faculty of Medicine
Principal Investigator	KIGAWA Junzo Tottori Univ.・Dept.Obstet.Gynecol., Assistant Professor
Project Period (FY)	1995 – 1996Completed
Keywords	ovarian cancer / chemoresistance / p53 gene / gene therapy
Research Abstract	The aim of this study was to know the role of p53-gene therapy for patients with chemoresistant ovarian cancer. To examine the role of p53 gene in the ...

Research Products of this project	Publications (19 results)

18. Coculture of preimplantation embryo with an immortalized human oviductal epithelial cells

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University, Faculty of Medicine
Principal Investigator	HARADA Tasuku Tottori Univ.・Dept.Obstet.Gynecol., Assistant Professor
Project Period (FY)	1994 – 1995Completed
Keywords	Oviductal epithelial cells / immortalize / basis fibroblast growth factor / FGF receptor 1
Research Abstract	We have tried establish an immortalized cell line of human tubal epithelium. It is not possible to obtain immortalized cells after repeated experiment ...

Research Products of this project	Publications (6 results)

19. Effects of medroxyprogesterone acetate and synthetic analogue of fumagillin on endometrial cancer

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University, Faculty of Medicine
Principal Investigator	TERAKAWA Naoki Tottori Univ., Dept.Obstet.Gynecol., Professor
Project Period (FY)	1994 – 1995Completed
Keywords	Endometrial Cancer / Nood mouse model / Anti-tumor effect / Medroxyprogesterone acetate / Synthetic analogue of fumagillin / Growth inhibition / Inhibition of angiogenesis
Research Abstract	This study was undertaken to investigate the effects of medroxyprogesterone acetate (MPA) and synthetic analogue of fumagillin (TNP-470) on the growth ...

Research Products of this project	Publications (13 results)

20. A combination therapy of danazol and GnRH agonist for endometriosis

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tottori University, Faculty of Medicine
Principal Investigator	TERAKAWA Naoki Tottori Uni. Dept. Obstet. Gynecol., Professor
Project Period (FY)	1992 – 1993Completed
Keywords	Endometriosis / Danazol / GnRH agonist / Combination therapy / Laparoscopy
Research Abstract	Autocrine growth mechanism of endometriosis and inhibitory effects of danazol and GnRH agonist on the growth of endometriosis were investigated Danazo ...

Research Products of this project	Publications (15 results)

Project Period (Start Year [FY])

1. The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois Research Project

HARADA Tasuku Tottori University

2. Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research Research Project

TERAKAWA Naoki 鳥取大学, 名誉教授

3. Molecular basis of methylation-dependent expression of aromatase gene in endometriosis Research Project

IZAWA Masao Tottori University

4. Adenovirus type 5 EIA gene therapy for ovarian carcinoma Research Project

ITAMOCHI Hiroaki Tottori University, Hospital, Associate Professor

5. Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis Research Project

TERAKAWA Naoki Tottori University, Professor

6. Order made gene therapy for epithelial ovarian cancer on biological behavior Research Project

KIGAWA Junzou Tottori Univ., Faculty of Medicine, Associate Professor

7. Development of drug treatment for endometriosis targeting cytokine signal transduction molecules Research Project

HARADA Tasuku Tottori University, Faculty of Medicine, Assistant Professor

8. Role of matrix met alloprot einases and cytokines in the development of endometriosis Research Project

TERAKAWA Naoki Tottori Univ., Dept.Obst et.Gynecol., Professor

9. Development of anti-cytokine drugs for treatment of endometriosis Research Project

HARADA Tasuku Tottori Univ., Dept.Obstet.Gunecol., Assistant Professor

10. Gene therapy enhances chemotherapy induced apoptosis in a peritonitis carcinomatosa model with ovarian cancer Research Project

KIGAWA Junzo Tottori Univ. Dept. Obstet. Gynecol., Associated Professor

11. Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis Research Project

TERAKAWA Naoki Tottori Univ.Dept.Obstet.Gynecol., Professor

12. Role of cytokines in development of endometriosis Research Project

HARADA Tasuku Tottori Univ., Sch. of Med., Obstetrics and Gynecology, Associated Professor

13. Chemoresistance and apoptotic pathway in ovarian cancer. Research Project

KANAMORI Yasunobu (1999-2000) Tottori Univ.Dept.Obstet.Gynecol., Research Associates 皆川 幸久 (1998) 鳥取大学, 医学部, 講師

14. Telomerase activity and p53-induced apoptosis Research Project

KIGAWA Junzo Tottori Univ. Sch. of Med., Obstetrics and Gynecology, Associated Professor

15. Interleukin-8 is a possible angiogenic factor in endometrial cancer Research Project

TERAKAWA Naoki Tottori Univ.Dept.Obstet.Gynecol., Professor

16. Overcoming cisplatin-resistance in ovarian cancer through induction of apoptosis by anticancer agents Research Project

MINAGAWA Yukihisa Tottori Univ.Dept.Obstet.Gynecol., Assistant Professor

17. p53-based gene therapy of ovarian cancer with chemo-resistance Research Project

KIGAWA Junzo Tottori Univ.・Dept.Obstet.Gynecol., Assistant Professor

18. Coculture of preimplantation embryo with an immortalized human oviductal epithelial cells Research Project

HARADA Tasuku Tottori Univ.・Dept.Obstet.Gynecol., Assistant Professor

19. Effects of medroxyprogesterone acetate and synthetic analogue of fumagillin on endometrial cancer Research Project

TERAKAWA Naoki Tottori Univ., Dept.Obstet.Gynecol., Professor

20. A combination therapy of danazol and GnRH agonist for endometriosis Research Project

TERAKAWA Naoki Tottori Uni. Dept. Obstet. Gynecol., Professor

1. The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois

Research Project

2. Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

Research Project

3. Molecular basis of methylation-dependent expression of aromatase gene in endometriosis

Research Project

4. Adenovirus type 5 EIA gene therapy for ovarian carcinoma

Research Project

5. Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis

Research Project

6. Order made gene therapy for epithelial ovarian cancer on biological behavior

Research Project

7. Development of drug treatment for endometriosis targeting cytokine signal transduction molecules

Research Project

8. Role of matrix met alloprot einases and cytokines in the development of endometriosis

Research Project

9. Development of anti-cytokine drugs for treatment of endometriosis

Research Project

10. Gene therapy enhances chemotherapy induced apoptosis in a peritonitis carcinomatosa model with ovarian cancer

Research Project

11. Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis

Research Project

12. Role of cytokines in development of endometriosis

Research Project

13. Chemoresistance and apoptotic pathway in ovarian cancer.

Research Project

KANAMORI Yasunobu (1999-2000) Tottori Univ.Dept.Obstet.Gynecol., Research Associates
皆川幸久 (1998) 鳥取大学, 医学部, 講師

14. Telomerase activity and p53-induced apoptosis

Research Project

15. Interleukin-8 is a possible angiogenic factor in endometrial cancer

Research Project

16. Overcoming cisplatin-resistance in ovarian cancer through induction of apoptosis by anticancer agents

Research Project

17. p53-based gene therapy of ovarian cancer with chemo-resistance

Research Project

18. Coculture of preimplantation embryo with an immortalized human oviductal epithelial cells

Research Project

19. Effects of medroxyprogesterone acetate and synthetic analogue of fumagillin on endometrial cancer

Research Project

20. A combination therapy of danazol and GnRH agonist for endometriosis

Research Project