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Search Results: 24 results / Researcher Number: 90163906

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  • 1. The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    HARADA Tasuku Tottori University

    Project Period (FY) 2008 – 2010Completed
    Keywords 子宮内膜症 / アポトーシス / survivin / サイトカイン
    Research Abstract Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis. Endometriotic stromal cells showed re ...
    Research Products of this project Journal Article (18 results, of which Peer Reviewed: 18 results)   Presentation (19 results)   Remarks (2 results)
  • 2. Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    TERAKAWA Naoki 鳥取大学, 名誉教授

    Project Period (FY) 2008 – 2011Completed
    Keywords JEMS / 子宮内膜症 / がん化 / 疫学研究
    Research Abstract This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data colle ...
    Research Products of this project Journal Article (32 results, of which Peer Reviewed: 29 results)   Presentation (45 results)   Remarks (5 results)
  • 3. Molecular basis of methylation-dependent expression of aromatase gene in endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    IZAWA Masao Tottori University

    Project Period (FY) 2006 – 2008Completed
    Keywords 子宮内膜症 / アロマターゼ遺伝子 / 遺伝子高発現 / エピジェネティクス制御異常 / CpGアイランド / DNA脱メチル化 / エストロゲン産生異常 / アポトーシス抵抗性 / 遺伝子発現異常 / PKC / アロマターゼ / エピジェネティクス
    Research Abstract 「子宮内膜症細胞にアロマターゼ遺伝子高発現をもたらす分子基盤にはエピジェネティクス制御が関与する」との仮説の検証を通して、子宮内膜症の高濃度エストロゲン環境を生じる分子基盤の解明をめざした。本研究により、子宮内膜症細胞にけるアロマターゼ遺伝子高発現の分子基盤ををエピジェネティクス制御の観点より検証し ...
    Research Products of this project Journal Article (12 results, of which Peer Reviewed: 11 results)   Presentation (13 results)
  • 4. Adenovirus type 5 EIA gene therapy for ovarian carcinoma

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    ITAMOCHI Hiroaki Tottori University, Hospital, Associate Professor

    Project Period (FY) 2005 – 2007Completed
    Keywords Carcinoma / Gene therapy / Chemoresponse
    Research Abstract Resistance of ovarian clear cell carcinoma (CCC) to platinum-based chemotherapy is associated with poor prognosis, and an effective treatment for adva ...
    Research Products of this project Journal Article (41 results, of which Peer Reviewed: 16 results)   Presentation (48 results)   Book (4 results)
  • 5. Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    TERAKAWA Naoki Tottori University, Professor

    Project Period (FY) 2005 – 2007Completed
    Keywords Endometrinsis / TNFα / IL-8 / dienogest / NFkB pathway / ovarian endometrioma / GnRH antagonist / Cetrorelix
    Research Abstract We previous reported that the proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-8 are elevated in the peritoneal f ...
    Research Products of this project Journal Article (33 results, of which Peer Reviewed: 16 results)   Presentation (40 results)
  • 6. Order made gene therapy for epithelial ovarian cancer on biological behavior

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    KIGAWA Junzou Tottori Univ., Faculty of Medicine, Associate Professor

    Project Period (FY) 2004 – 2006Completed
    Keywords ovarian cancer / genetic diagnosis / gene therapy
    Research Abstract Gene therapy has been tried however, its success is limited in patients who develop chemoresistance a distinctly different clinical behavior. Many mec ...
    Research Products of this project Journal Article (17 results)
  • 7. Development of drug treatment for endometriosis targeting cytokine signal transduction molecules

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution National University Corporation Tottori University
    Principal Investigator

    HARADA Tasuku Tottori University, Faculty of Medicine, Assistant Professor

    Project Period (FY) 2004 – 2005Completed
    Keywords endometriosis / interleukin-8 / interleukin-6 / tumor necrosis factor alpha / NF-kB / progesterone / danazol / dienogest
    Research Abstract We previously showed that interleukin-8(IL-8) and tumor necrosis factor-a(TNFa) are significantly elevated in the PF of women with endometriosis compa ...
    Research Products of this project Journal Article (19 results)
  • 8. Role of matrix met alloprot einases and cytokines in the development of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    TERAKAWA Naoki Tottori Univ., Dept.Obst et.Gynecol., Professor

    Project Period (FY) 2002 – 2003Completed
    Keywords Endometriosis / Development and progression / Endometriotic stromal cells / Cytokine TNFα / IL-8 / Nuclear fact or-κB / Estrogen / GnRH agonist
    Research Abstract It is believed that the extracellular matrix (ECM) remodeling is relevant to the development and the progression of endometriosis. Tissue remodeling i ...
    Research Products of this project Publications (24 results)
  • 9. Development of anti-cytokine drugs for treatment of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    HARADA Tasuku Tottori Univ., Dept.Obstet.Gunecol., Assistant Professor

    Project Period (FY) 2001 – 2003Completed
    Keywords endometriosis / cytokine / interleukin-8 / tumor necrosis factor alpha / anti-TNF alpha antibody
    Research Abstract Peritoneal fluid (PF) in women with endometriosis contains an increased number of activated macrophages that secrete a variety of cytokines. We have p ...
    Research Products of this project Publications (39 results)
  • 10. Gene therapy enhances chemotherapy induced apoptosis in a peritonitis carcinomatosa model with ovarian cancer

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    KIGAWA Junzo Tottori Univ. Dept. Obstet. Gynecol., Associated Professor

    Project Period (FY) 2000 – 2002Completed
    Keywords P53 gene / apoptosis / lperitonitis carcinomatosa model / gene therapy / ovarian cancer
    Research Abstract We found that mutations of the p53 gene newly occurred in 47% of patients after recurrence. Nonresponders to chemotherapy had mutations of the p53 gen ...
    Research Products of this project Publications (41 results)
  • 11. Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B).

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    TERAKAWA Naoki Tottori Univ.Dept.Obstet.Gynecol., Professor

    Project Period (FY) 1999 – 2000Completed
    Keywords Endometriosis / Pathogenesis / Infertility / Endometriotic stromal cells / Peritoneal macrophages / Cytokines / IL-6 / IL-8
    Research Abstract Endometriosis, which occurs in 10% of reproductive aged women, is characterized by the presence and growth of endometrial-like tissue outside the uter ...
    Research Products of this project Publications (11 results)
  • 12. Role of cytokines in development of endometriosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    HARADA Tasuku Tottori Univ., Sch. of Med., Obstetrics and Gynecology, Associated Professor

    Project Period (FY) 1998 – 1999Completed
    Keywords endometriosis / cytokine / MMP / TIMP / interleukin-6 / interleukin-10 / endometrium / IL-6 soluble receptor
    Research Abstract We have measured peritoneal fluid (PF) levels of matrix metalloproteinase-9 (MMP-9), its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1) a ...
    Research Products of this project Publications (24 results)
  • 13. Chemoresistance and apoptotic pathway in ovarian cancer.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University School of Medicine
    Principal Investigator

    KANAMORI Yasunobu (1999-2000) Tottori Univ.Dept.Obstet.Gynecol., Research Associates
    皆川 幸久 (1998) 鳥取大学, 医学部, 講師

    Project Period (FY) 1998 – 2000Completed
    Keywords Ovarian cancer / Apoptosis / Chemosensitivity / Cisplatin / p53
    Research Abstract 1. The effect of p53 gene transduction to chemosensitivity.
    Research Products of this project Publications (25 results)
  • 14. Telomerase activity and p53-induced apoptosis

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University
    Principal Investigator

    KIGAWA Junzo Tottori Univ. Sch. of Med., Obstetrics and Gynecology, Associated Professor

    Project Period (FY) 1997 – 1999Completed
    Keywords telomerae / ovarian cancer apoptosis / p53 / gene-therapy / telomere
    Research Abstract Although p53 gene mutation is frequently seen in ovarian cancer, the function of p53 gene in chemosensitivity is not conclusively defined. First, we e ...
    Research Products of this project Publications (30 results)
  • 15. Interleukin-8 is a possible angiogenic factor in endometrial cancer

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University (School of Medicine)
    Principal Investigator

    TERAKAWA Naoki Tottori Univ.Dept.Obstet.Gynecol., Professor

    Project Period (FY) 1996 – 1997Completed
    Keywords Endometrial cancer / Angiogenic factor / Tumor necrosis factor a / Interleukin-8 / Stromal cells / Microvessel density / Cancer growth / Paracrine effect
    Research Abstract This study was undertaken to find out the candidate of an angiogenic factor (s) in endometrial carcinoma. In recent clinical studies, we have found th ...
    Research Products of this project Publications (24 results)
  • 16. Overcoming cisplatin-resistance in ovarian cancer through induction of apoptosis by anticancer agents

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University (School of Medicine)
    Principal Investigator

    MINAGAWA Yukihisa Tottori Univ.Dept.Obstet.Gynecol., Assistant Professor

    Project Period (FY) 1995 – 1997Completed
    Keywords apoptosis / topoisomerase / cicplatin-resistance / ovarian cancer
    Research Abstract The aim of the present study was to clarify the relation between quantitative and/or qualitative changes of DNA topoisomerase (Topo) and the ability o ...
    Research Products of this project Publications (24 results)
  • 17. p53-based gene therapy of ovarian cancer with chemo-resistance

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University, Faculty of Medicine
    Principal Investigator

    KIGAWA Junzo Tottori Univ.・Dept.Obstet.Gynecol., Assistant Professor

    Project Period (FY) 1995 – 1996Completed
    Keywords ovarian cancer / chemoresistance / p53 gene / gene therapy
    Research Abstract The aim of this study was to know the role of p53-gene therapy for patients with chemoresistant ovarian cancer. To examine the role of p53 gene in the ...
    Research Products of this project Publications (19 results)
  • 18. Coculture of preimplantation embryo with an immortalized human oviductal epithelial cells

    Research Project

    Research Category

    Grant-in-Aid for General Scientific Research (C)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University, Faculty of Medicine
    Principal Investigator

    HARADA Tasuku Tottori Univ.・Dept.Obstet.Gynecol., Assistant Professor

    Project Period (FY) 1994 – 1995Completed
    Keywords Oviductal epithelial cells / immortalize / basis fibroblast growth factor / FGF receptor 1
    Research Abstract We have tried establish an immortalized cell line of human tubal epithelium. It is not possible to obtain immortalized cells after repeated experiment ...
    Research Products of this project Publications (6 results)
  • 19. Effects of medroxyprogesterone acetate and synthetic analogue of fumagillin on endometrial cancer

    Research Project

    Research Category

    Grant-in-Aid for General Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University, Faculty of Medicine
    Principal Investigator

    TERAKAWA Naoki Tottori Univ., Dept.Obstet.Gynecol., Professor

    Project Period (FY) 1994 – 1995Completed
    Keywords Endometrial Cancer / Nood mouse model / Anti-tumor effect / Medroxyprogesterone acetate / Synthetic analogue of fumagillin / Growth inhibition / Inhibition of angiogenesis
    Research Abstract This study was undertaken to investigate the effects of medroxyprogesterone acetate (MPA) and synthetic analogue of fumagillin (TNP-470) on the growth ...
    Research Products of this project Publications (13 results)
  • 20. A combination therapy of danazol and GnRH agonist for endometriosis

    Research Project

    Research Category

    Grant-in-Aid for General Scientific Research (B)

    Research Field Obstetrics and gynecology
    Research Institution Tottori University, Faculty of Medicine
    Principal Investigator

    TERAKAWA Naoki Tottori Uni. Dept. Obstet. Gynecol., Professor

    Project Period (FY) 1992 – 1993Completed
    Keywords Endometriosis / Danazol / GnRH agonist / Combination therapy / Laparoscopy
    Research Abstract Autocrine growth mechanism of endometriosis and inhibitory effects of danazol and GnRH agonist on the growth of endometriosis were investigated Danazo ...
    Research Products of this project Publications (15 results)
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