International support for the reseach activities for the production, function and structure of neo-self

2022 Fiscal Year Final Research Report

• Project Area: Creation, function and structure of neo-self
• Project/Area Number: 16K21731
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Biological Sciences
• Research Institution: The University of Tokushima
• Principal Investigator: MATSUMOTO Mitsuru 徳島大学, 先端酵素学研究所(次世代), 教授 (60221595)
• Co-Investigator(Kenkyū-buntansha): 横須賀 忠 東京医科大学, 医学部, 主任教授 (10359599)
• Project Period (FY): 2016-06-30 – 2023-03-31
• Keywords: ネオ・セルフ / 国際活動支援

Outline of Final Research Achievements

In this research area, we aimed to elucidate the antigen-recognition mechanism of T cells and B cells and studied the properties of the immunological self. In other words, given that individual differences in the production of “neo-self” antigens and immune responses are based on differences in HLA, which differ from individual to individual, rather than the conventional “self” vs. “neo-self” immune response, the immune response I engaged in academic activities with the desire to clarify the role of HLA in Therefore, international academic activities are extremely important in this research area, and in order to arrive at the “neo-self” concept, not only immunology but also the integration of knowledge from different fields such as genetics and three-dimensional structural analysis is required. I proceeded with my research while realizing the need for important, multidisciplinary research to be conducted on a global scale.

Free Research Field

国際活動支援

Academic Significance and Societal Importance of the Research Achievements

研究期間の前半では若手研究者の育成や本領域の研究活動の広報を目指して、海外の研究室への短期間派遣や国際シンポジウムを開催するなど、当初予定した活動が実施出来たと言える。しかしながら、COVID-19の蔓延によりこうした活動が制限された活動期間の後半では、重要な研究資材としての遺伝子改変マウスを多くの研究者に利用していただけるよう米国ジャクソン研究所に登録し、世界中の研究者が利用するためのリソースとして寄託することで本領域のミッションを果たしたと考えている。今後はこれらのバイオリソースの提供と研究成果の国際誌への誌上発表を介して本領域活動が広く周知されることを目指し続ける。