2019 Fiscal Year Final Research Report

Integrative understanding of biological phenomena with temperature as a key theme

Administrative Group

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Project Area	Integrative understanding of biological phenomena with temperature as a key theme
Project/Area Number	15H05927
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Biological Sciences
Research Institution	Center for Novel Science Initatives, National Institutes of Natural Sciences (2018-2019) Okazaki Research Facilities, National Institutes of Natural Sciences (2015-2017)
Principal Investigator	TOMINAGA Makoto 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90260041)
Project Period (FY)	2015-06-29 – 2020-03-31
Keywords	温度生物学 / 生理学 / 神経科学
Outline of Final Research Achievements	This research project concerns two subgroups, ‘temperature sensing’ and ‘temperature-responding systems’, and sought to integrate our understanding of temperature-dependent biological phenomena with the development of techniques that detect and regulate local temperatures in cells and organs. In this project we clarified: 1) How temperature-sensing mechanisms in the plasma membrane and in cells work together to allow precise temperature detection; 2) How temperature is sensed and integrated in temperature-dependent physiological responses that include regulation of body temperature, metabolism, circadian clock and animal behavior; and 3) What are the mechanisms and physiological functions of spatiotemporal non-homogeneity of temperature distribution and detection. A general team organized directed research group activities to facilitate the fruitful collaboration and made effective outreach activities for the people who are normally not involved in science.
Free Research Field	分子細胞生理学
Academic Significance and Societal Importance of the Research Achievements	以下の目的を達成したことが学術的意義であり、その成果をHPや公開シンポジウム等の様々な方法で社会に発信し続けたことが社会的意義である。1)「温度センシング」では、細胞膜と細胞内の温度センシング機構が協働して、細胞が温度を感知し機能発現にいたるメカニズムを明らかにする。2)「温度応答システム」では、感知された温度情報が統合され、個体レベルでの体温・代謝調節、生体リズム調節、行動制御などの生理現象にいたる生体メカニズムを明らかにする。3) 温度分布と温度感知の空間的不均一性と時間的変動の発生機序と生理的役割を明らかにする。