宇宙からひも解く新たな生命制御機構の統合的理解

2019 Fiscal Year Annual Research Report

• Project Area: "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
• Project/Area Number: 15H05935
• Research Institution: Japan Aerospace EXploration Agency
• Principal Investigator: 古川 聡 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 上席研究開発員 (20726260)
• Co-Investigator(Kenkyū-buntansha): 根井 充 国立研究開発法人量子科学技術研究開発機構, 本部 安全管理部, 部長(任常) (10164659) ; 松崎 一葉 筑波大学, 医学医療系, 教授 (10229453) ; 日出間 純 東北大学, 生命科学研究科, 准教授 (20250855) ; 東端 晃 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (30360720) ; 東谷 篤志 東北大学, 生命科学研究科, 教授 (40212162) ; 成瀬 恵治 岡山大学, 医歯薬学総合研究科, 教授 (40252233) ; 瀬原 淳子 京都大学, ウイルス・再生医科学研究所, 連携教授 (60209038) ; 高橋 昭久 群馬大学, 重粒子線医学推進機構, 教授 (60275336) ; 井上 夏彦 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (60277811) ; 長瀬 博 筑波大学, 国際統合睡眠医科学研究機構, 教授 (70383651) ; 森田 啓之 岐阜大学, 大学院医学系研究科, 教授 (80145044) ; 岩崎 賢一 日本大学, 医学部, 教授 (80287630) ; 那須 正夫 大阪大谷大学, 薬学研究科, 教授 (90218040)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: 宇宙 / 無重力 / ストレス / 放射線 / 微生物

Outline of Annual Research Achievements

長期宇宙滞在時、無重力の物理ストレスは筋萎縮や骨密度低下を、閉鎖環境の精神的ストレスは体内リズム不調を、放射線被ばく等の環境リスクはDNA変異等をきたす。有人宇宙探査で超長期宇宙滞在に挑戦する時代にあり、これらは解決すべき課題である。同時にこれら課題への深い理解は、地上の高齢化・ストレス社会における生命維持・恒常性の担保に貢献し、健康長寿社会につながる。
本領域では、11の計画研究と30の公募研究の相乗的展開で下記3プロジェクトに体系化し、地球上の生命体が有する恒常性維持と破綻に関する統一的理解に努めた。2019年度(繰越の2020年度を含む)は新たに73報の論文が発行された。
1)重力影響による骨・筋・前庭・循環系・免疫機能の恒常性維持と破綻-細胞からモデル小動物、線虫、メダカ、ゼブラフィッシュ、マウスを用いた宇宙実験、過重力実験、さらには宇宙長期滞在の宇宙飛行士の影響などについて研究を進めた。細胞、組織から器官、それらのネットワーク、個体レベルで、それぞれ重力感受と適応応答機構ならびにその分子基盤を特定した。
2)閉鎖環境による「睡眠・心身の恒常性維持と破綻」-主にマウスとヒトを対象にした研究を展開し、重力影響では体循環調節機能に影響が現れるが、閉鎖環境ストレスではその影響はみられず、一方で脳循環調節機能を減弱させること、脳血流の変化、更に新たなストレスマーカー候補を検討した。また、ストレスと関連が深い睡眠・覚醒の領域においては新たな睡眠診断デバイス、不眠症治療薬の評価分析、眠気の分子的実体を捉えるなど世界トップレベルでの研究を展開・達成することができた。
3)微生物や宇宙放射線など外部環境リスクによる「生体の恒常性維持と破綻」-無重力と閉鎖環境を組み合わせた複合影響を研究するため、新規装置開発、メタゲノム解析、蛍光プローブやバイオイメージングなど新たなモニタリングシステムの開発も行った。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] バージニア大学/コロラド州立大学/Prairie View A&M University(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: バージニア大学/コロラド州立大学/Prairie View A&M University
  • # of Other Institutions: 4
• [Int'l Joint Research] ドイツ航空宇宙センター(ドイツ)
  • Country Name: GERMANY
  • Counterpart Institution: ドイツ航空宇宙センター
• [Int'l Joint Research] パスツール研究所(フランス)
  • Country Name: FRANCE
  • Counterpart Institution: パスツール研究所
• [Int'l Joint Research] バルセロナ大学/Pompeu Fabra University(スペイン)
  • Country Name: SPAIN
  • Counterpart Institution: バルセロナ大学/Pompeu Fabra University
• [Int'l Joint Research] ベルゲン大学(ノルウェー)
  • Country Name: NORWAY
  • Counterpart Institution: ベルゲン大学
• [Int'l Joint Research]
  • # of Other Countries: 1
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  • Author(s): Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, and Michihiro Mieda
  • Journal Title: PNAS Volume: 118(6), Pages: e2010168118
  • DOI: 10.1073/pnas.2010168118
  • Peer Reviewed
• [Journal Article] Identification of fungi isolated from astronaut nasal and pharyngeal smears and saliva (2021)
  • Author(s): Kazuo Satoh, Takashi Yamazaki, Satoshi Furukawa, Chiaki Muka, Koichi Makimura
  • Journal Title: Microbiol Immunol Volume: 65(2) Pages: 89-94
  • DOI: 10.1111/1348-0421.12872
  • Peer Reviewed
• [Journal Article] Self‐Emergent Protocells Generated in an Aqueous Solution with Binary Macromolecules through Liquid‐Liquid Phase Separation (2020)
  • Author(s): Sakuta H, Fujita F Hamada T Hayashi M, *Takiguchi K (研究協力者), *Tsumoto K, Yoshikawa K (研究協力者)
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  • DOI: 10.1002/cbic.202000344
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  • Author(s): Takeshi Nikawa, Kazumi Ishidoh
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  • DOI: 10.1016/j.bbapap.2020.140495
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• [Journal Article] How does spaceflight affect the acquired immune system? (2020)
  • Author(s): Akiyama T, Horie K, Hinoi E, Hiraiwa M, Kato A, Maekawa Y, Takahashi A, Furukawa S.
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• [Journal Article] Long-duration spaceflight alters estimated intracranial pressure and cerebral blood velocity (2020)
  • Author(s): Ken-ichi Iwasaki, Yojiro Ogawa, Takuya Kurazumi, Syed M. Imaduddin, Chiaki Mukai, Satoshi Furukawa, Ryo Yanagida, Tomokazu Kato, Toru Konishi, Ari Shinojima, Benjamin D. Levine, Thomas Heldt
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  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 30 Pages: 127360-127360
  • DOI: 10.1016/j.bmcl.2020.127360
  • Peer Reviewed
• [Journal Article] Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need (2020)
  • Author(s): Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Takato Honda, Jinhwan Choi, Fuyuki Asano, Seiya Mizuno, Satoru Takahashi, Masashi Yanagisawa, Hiromasa Funato
  • Journal Title: Scientific Reports Volume: 10 Pages: 8676
  • DOI: 10.1038/s41598-020-65647-0
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• [Journal Article] Myonectin inhibits the differentiation of osteoblasts and osteoclasts in mouse cells. (2020)
  • Author(s): Kawaguchi M, Kawao N, Takafuji Y, Ishida M, Kaji H.
  • Journal Title: Heliyon Volume: 6 Pages: e03967
  • DOI: 10.1016/j.heliyon.2020.e03967.
  • Peer Reviewed / Open Access
• [Journal Article] Extracellular vesicles secreted from mouse muscle cells suppress osteoclast formation: Roles of mitochondrial energy metabolism. (2020)
  • Author(s): Takafuji Y, Tatsumi K, Ishida M, Kawao N, Okada K, Kaji H.
  • Journal Title: Bone Volume: 134 Pages: 115298
  • DOI: 10.1016/j.bone.2020.115298
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• [Journal Article] VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice. (2020)
  • Author(s): Abe C, Yamaoka Y, Maejima Y, Mikami T, Yokota S, Yamanaka A, Morita H
  • Journal Title: Commu Biol Volume: 3 Pages: 227
  • DOI: 10.1038/s42003-020-0950-0
  • Peer Reviewed / Open Access
• [Journal Article] Adaptive responses of histone modifications to resistance exercise in human skeletal muscle. (2020)
  • Author(s): Lim CH, Shimizu J, Kawano F, Kim HJ, Kim CK
  • Journal Title: PLoS ONE Volume: 15 Pages: e0231321
  • DOI: 10.1371/journal.pone.0231321
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles of Dkk2 in the linkage from muscle to bone during mechanical unloading in mice. (2020)
  • Author(s): Kawao N, Morita H, Iemura S, Ishida M, Kaji H.
  • Journal Title: Int J Mol Sci Volume: 21 Pages: 2547
  • DOI: 10.3390/ijms21072547
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• [Journal Article] A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule. (2020)
  • Author(s): Ohgami N, He T, Oshino-Negishi R, Gu Y, Li X, Kato M.
  • Journal Title: J Toxicol Environ Health A Volume: 83(5) Pages: 215-218
  • DOI: 10.1080/15287394.2020.1746945
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• [Journal Article] Combined-environment simulator for low-dose-rate radiation and partial gravity of Moon and Mars (2020)
  • Author(s): Akihisa Takahashi, Sakuya Yamanouchi, Kazuomi Takeuchi, Shogo Takahashi, Mutsumi Tashiro, Jun Hidema, Atsushi Higashitani, Takuya Adachi, Shenke Zhang, Fady Nagy Lotfy Guirguis, Yukari Yoshida, Aiko Nagamatsu, Megumi Hada
  • Journal Title: life Volume: 10(11) Pages: E274
  • DOI: 10.3390/life10110274
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations (2020)
  • Author(s): Sakuya Yamanouchi, Jordan Rhone, Jian-Hua Mao, Keigi Fujiwara, Premkumar B. Saganti, Akihisa Takahashi, and Megumi Hada
  • Journal Title: life Volume: 10(9) Pages: E187
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• [Journal Article] Targeted Central Nervous System Irradiation of Caenorhabditis elegans Induces a Limited Effect on Motility (2020)
  • Author(s): *Michiyo Suzuki, Zu Soh, Hiroki Yamashita, Toshio Tsuji, Tomoo Funayama
  • Journal Title: Biology Volume: 9 Pages: 289
  • DOI: 10.3390/biology9090289
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• [Journal Article] Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation (2020)
  • Author(s): Hirotaka Tachibana1,3, Takamitsu Morioka1,*, Kazuhiro Daino1, Yi Shang1, Mari Ogawa1, Misuzu Fujita1, Akira Matsuura3,4, Hiroyuki Nogawa3,4, Yoshiya Shimada2,† and Shizuko Kakinuma1,*
  • Journal Title: Journal of radiation research Volume: 61(5) Pages: 648-656
  • DOI: 10.1093/jrr/rraa055
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• [Journal Article] Nrf2 contributes to the weight gain of mice during space travel (2020)
  • Author(s): Suzuki T, Uruno A, Yumoto A, Suzuki N, Kudo T, Kensler TW, Takahashi S, Shiba D, Yamamoto M et al.
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  • DOI: 10.1038/s42003-020-01227-2
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• [Journal Article] The skin mycobiome of an astronaut during a 1-year stay on the International Space Station (2020)
  • Author(s): *Takashi Sugita , Takashi Yamazaki , Otomi Cho , Satoshi Furukawa and Chiaki Mukai
  • Journal Title: Medical Mycology Volume: N/A Pages: myaa067
  • DOI: 10.1093/mmy/myaa067
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• [Journal Article] Chloroplast Autophagy and Ubiquitination Combine toManage Oxidative Damage andStarvation Responses (2020)
  • Author(s): Yuta Kikuchi, Sakuya Nakamura, Jesse D. Woodson, Hiroyuki Ishida, Qihua Ling, Jun Hidema, R. Paul Jarvis, Shinya Hagihara,band Masanori Izumi
  • Journal Title: Plant Physiology Volume: 183 Pages: 1531-1544
  • DOI: 10.1104/pp.20.00237
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• [Journal Article] Iron Ladies - How Desiccated Asexual Rotifer Adineta vaga Deal With X-Rays and Heavy Ions? (2020)
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• [Journal Article] The Responses of the Black Fungus Cryomyces Antarcticus to High Doses of Accelerated Helium Ions Radiation within Martian Regolith Simulants and Their Relevance for Mars (2020)
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• [Journal Article] Applications of Genome Editing Technology in Research on Chromosome Aneuploidy Disorders. (2020)
  • Author(s): Akutsu SN, Fujita K, Tomioka K, *Miyamoto T, *Matsuura S.
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  • Peer Reviewed
• [Journal Article] Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight (2019)
  • Author(s): Horie K, Kato T, Kudo T, Sasanuma H, Miyauchi M, Akiyama N, Miyao T, Seki T, Ishikawa T, Takakura Y, Shirakawa M, Shiba D, Hamada M, Jeon H, Yoshida N, Inoue JI, Muratani M, Takahashi S, Ohno H, Akiyama T.
  • Journal Title: Sci Rep. Volume: 9 Pages: 19866
  • DOI: 10.1038/s41598-019-56432-9
  • Peer Reviewed / Open Access
• [Journal Article] Biological effects of anti-RANKL antibody and zoledronic acid on growth and tooth eruption in growing mice. (2019)
  • Author(s): Isawa M, Karakawa A, Sakai N, Nishina S, Kuritani M, Chatani M, Negishi-Koga T, Sato M, Inoue M, Shimada Y, Takami M.
  • Journal Title: Scientific reports Volume: 9 Pages: 19895
  • DOI: 10.1038/s41598-019-56151-1.
  • Peer Reviewed / Open Access
• [Journal Article] Roles of monocarboxylate transporter subtypes in promotionand suppression of osteoclast differentiation and survival on bone. (2019)
  • Author(s): Imai H, Yoshimura K, Miyamoto Y, Sasa K, Sugano M, Chatani M, Takami M, Yamamoto M, and Kamijo R.
  • Journal Title: Scientific reports Volume: 9 Pages: 15608
  • DOI: 10.1038/s41598-019-52128-2
  • Peer Reviewed / Open Access
• [Journal Article] Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate (2019)
  • Author(s): *Arai HN, Sato F,Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, *Sehara-Fujisawa A
  • Journal Title: Cell Reports Volume: 29 Pages: 603-616
  • DOI: 10.1016/j.celrep.2019.09.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A bidirectional network for appetite control in larval zebrafish (2019)
  • Author(s): Caroline Lei Wee, Erin Yue Song, Robert Evan Johnson, Deepak Ailani, Owen Randlett, Ji-Yoon Kim, Maxim Nikitchenko, Armin Bahl, Chao-Tsung Yang, Misha B Ahrens, Koichi Kawakami, Florian Engert, Sam Kunes
  • Journal Title: eLIFE Volume: 8 Pages: e43775
  • DOI: 10.7554/eLife.43775
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment with synthetic glucocorticoid impairs bone metabolism, as revealed by in vivo imaging of osteoblasts and osteoclasts in medaka fish. (2019)
  • Author(s): Yuki Azetsu, Masahiro Chatani, Yusuke Dodo, Akiko Karakawa, Nobuhiro Sakai, Takako Negishi-Koga, Masamichi Takami
  • Journal Title: Biomedicine & Pharmacotherapy Volume: 118 Pages: -
  • DOI: 10.1016/j.biopha.2019.109101
  • Peer Reviewed / Open Access
• [Journal Article] Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson’s disease model mice. (2019)
  • Author(s): Handa K, Kiyohara S, Yamakawa T, Ishikawa K, Hosonuma M, Sakai N, Karakawa A, Chatani M, Tsuji M, Inagaki K, Kiuchi Y, Takami M, Negishi-Koga T.
  • Journal Title: Scientific reports Volume: 9 Pages: 13768
  • DOI: 10.1038/s41598-019-50336-4.
  • Peer Reviewed / Open Access
• [Journal Article] Hypergravity induces vertebrae and otolith deformation in medaka fish (2019)
  • Author(s): Masahiro Chatani, Aiko Mitsuhashi, Yusuke Dodo, Nobuhiro Sakai, and Masamichi Takami
  • Journal Title: Biological Sciences in Space Volume: 33 Pages: 12-17
  • DOI: 10.2187/bss.33.12
  • Peer Reviewed / Open Access
• [Journal Article] Male mice, caged in the International Space Station for 35 days, sire healthy offspring. (2019)
  • Author(s): Matsumura T, Noda T, Muratani M, Okada R, Yamane M, Isotani A, Kudo T, Takahashi S, *Ikawa M.
  • Journal Title: Sci Rep. Volume: 9(1) Pages: 13733
  • DOI: 10.1038/s41598-019-50128-w
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans. (2019)
  • Author(s): Sudevan S, Takiura M, Kubota Y, Higashitani N, Cooke M, Ellwood RA, Etheridge T, Szewczyk NJ, Higashitani A.
  • Journal Title: FASEB J. Volume: 33 Pages: 9540-9550
  • DOI: 10.1096/fj.201802298R.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating. (2019)
  • Author(s): Li H, Xu J, Tang M, Shen ZS, Wang GM, Tnag M, Du XR, Lv YT, Wang JJ, Zhang FF, Qi Z, Zhang Z, Sokabe M*, Tnag QY*
  • Journal Title: J Biol Chem Volume: 294 Pages: 11892-11909
  • DOI: 10.1074/jbc.RA118.005511.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neural signatures of sleep in zebrafish (2019)
  • Author(s): Louis C Leung, Gordon X Wang, Romain Madelaine, Gemini Skariah, Koichi Kawakami, Karl Deisseroth, Alexander E Urban, and Philippe Mourrain
  • Journal Title: Nature Volume: 571 Pages: 198-204
  • DOI: 10.1038/s41586-019-1336-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis. (2019)
  • Author(s): Hiraiwa M, Ozaki K, Yamada T, Iezaki T, Park G, Fukasawa K, Horie T, Kamada H, Tokumura K, Motono M, Kaneda K, Hinoi E.
  • Journal Title: Front Pharmacol Volume: 10 Pages: 684
  • DOI: 10.3389/fphar.2019.00684
  • Peer Reviewed / Open Access
• [Journal Article] The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway. (2019)
  • Author(s): Ozaki K, Yamada T, Horie T, Ishizaki A, Hiraiwa M, Iezaki T, Park G, Fukasawa K, Kamada H, Tokumura K, Motono M, Kaneda K, Ogawa K, Ochi H, Sato S, Kobayashi Y, Shi YB, Taylor PM, Hinoi E.
  • Journal Title: Sci Signal. Volume: 12 Pages: eaaw3921
  • DOI: 10.1126/scisignal.aaw3921
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tensile loads on tethered actin filaments induce accumulation of cell adhesion-associated proteins in vitro. (2019)
  • Author(s): Kiyoshima D, Tatsumi H, Hirata H, Sokabe M*.
  • Journal Title: Langmuir Volume: 35(23) Pages: 7443-7451
  • DOI: 10.1021/acs.langmuir.8b02076.
  • Peer Reviewed
• [Journal Article] Biophysical mechanisms of membrane thickness dependent MscL gating: An all atom molecular dynamics study. (2019)
  • Author(s): Katsuta H, Sawada Y, Sokabe M*.
  • Journal Title: Langmuir Volume: 35(23) Pages: 7432-7442
  • DOI: 10.1021/acs.langmuir.8b02074.
  • Peer Reviewed
• [Journal Article] An influenza-derived membrane tension-modulating peptide regulates cell movement and morphology via actin remodeling. (2019)
  • Author(s): Masuda T, Baba K, Nomura T, Tsujita K, Maruyama T, Itoh T, Sokabe M, Inagaki N, Futaki S
  • Journal Title: Commun Biol Volume: 2 Pages: 243
  • DOI: 10.1038/s42003-019-0486-3.
  • Peer Reviewed / Open Access
• [Journal Article] TRPC6 regulates phenotype switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN (2019)
  • Author(s): Takuro Numaga-Tomita, Tsukasa Shimauchi, Sayaka Oda,
  • Journal Title: FASEB J Volume: 33 Pages: 9785-9796
  • DOI: 10.1096/fj.201802811R
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel. (2019)
  • Author(s): Kenta Horie, Hiroki Sasanuma, Takashi Kudo, Shin-ichiro Fujita, Maki Miyauchi, Takahisa Miyao, Takao Seki, Nobuko Akiyama, Yuki Takakura, Miki Shimbo, Hyojung Jeon, Masaki Shirakawa, Dai Shiba, Nobuaki Yoshida, Masafumi Muratani, Satoru Takahashi & Taishin Akiyama
  • Journal Title: Scientific Report Volume: 9 Pages: 7654
  • DOI: 10.1038/s41598-019-44067-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2 (2019)
  • Author(s): Ken Takahashi, Shogo Hayashi, Mari Miyajima, Marei Omori, Jing Wang, Keiko Kaihara, Masatoshi Morimatsu, Chen Wang, Jian Chen, Gentaro Iribe, Keiji Naruse, Masahiro Sokabe
  • Journal Title: Cell Calcium Volume: 79 Pages: 68-74
  • DOI: 10.1016/j.ceca.2019.02.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PDH-mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in (2019)
  • Author(s): Hori S, Hiramuki Y, Nishimura D, Sato F, Sehara-Fujisawa A.
  • Journal Title: FASEB J Volume: 33 Pages: 8094-8109
  • DOI: 10.1096/fj.201802479R
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct modes of death in human neural stem and glioblastoma cells irradiated with carbon-ion radiation and gamma-rays (2019)
  • Author(s): Yuichiro Yokota, Yutaka Wada, Tomoo Funayama
  • Journal Title: International Journal of Radiation Biology Volume: 96 Pages: 172-178
  • DOI: 10.1080/09553002.2020.1683639
  • Peer Reviewed
• [Journal Article] Diallyl disulfide mitigates DNA damage and spleen tissue effects after irradiation (2019)
  • Author(s): Tetsuo Nakajima, Guillaume Vares, Yasuharu Ninomiya, Bing Wang, Takanori Katsube, Kaoru Tanaka, Kouichi Maruyama, and Mitsuru Nenoi
  • Journal Title: Medical Science Monitor Volume: 25 Pages: 8920-8927
  • DOI: 10.12659/MSM.917207
  • Peer Reviewed / Open Access
• [Journal Article] Expression profile of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity (2019)
  • Author(s): Ikeda H, Muratani M, Hidema J, Hada M, Fujiwara K, Souda H, Yoshida Y, *Takahashi A
  • Journal Title: Int J Mol Sci Volume: 20 Pages: 4791
  • DOI: 10.3390/ijms20194791
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Culture independent approach reveals domination of human-oriented microbes in a pharmaceutical manufacturing facility (2019)
  • Author(s): Mako Kawai, Tomoaki Ichijo, Yuji Takahashi, Miyako Noguchi, Hirohito Katayama, Otomi Cho, Takashi Sugita, Masao Nasu
  • Journal Title: European Journal of Pharmaceutical Sciences Volume: 137 Pages: 104973
  • DOI: 10.1016/j.ejps.2019.104973
  • Peer Reviewed
• [Journal Article] Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1 (2019)
  • Author(s): Takafumi Suzuki1, Aki Muramatsu, Ryota Saito, Tatsuro Iso, Takahiro Shibata, Keiko Kuwata, Shin-ichi Kawaguchi, Takao Iwawaki, Saki Adachi, Hiromi Suda, Masanobu Morita, Koji Uchida, Liam Baird, Masayuki Yamamoto
  • Journal Title: Cell Reports Volume: 28 Pages: 746-758
  • DOI: 10.1016/j.celrep.2019.06.047
  • Peer Reviewed / Open Access
• [Journal Article] Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak (2019)
  • Author(s): Dylan Buglewicz, Austin Banks, Hirokazu Hirakawa, Akira Fujimori & Takamitsu Kato*
  • Journal Title: Scientific Reports Volume: 9 Pages: 6157
  • DOI: 10.1038/s41598-019-42600-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of gravity direction on water transport in sweetpotato plants (2019)
  • Author(s): Ayako Tokuda and *Yoshiaki Kitaya
  • Journal Title: Biological Sciences in Space Volume: 33 Pages: 18-21
  • DOI: 10.2187/bss.33.18
  • Peer Reviewed
• [Journal Article] Acute Social Defeat Stress Increases Sleep in Mice (2019)
  • Author(s): Fujii S, Kaushik MK, Zhou X, Korkutata M, Lazarus M
  • Journal Title: Frontiers in Neuroscience Volume: 13 Pages: -
  • DOI: 10.3389/fnins.2019.00322
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 廃用性筋萎縮と食成分 (2020)
  • Author(s): *二川健
  • Organizer: 第22回健康栄養シンポジウム
  • Invited
• [Presentation] 宇宙医学から得られた筋萎縮に関する最新の知見 (2020)
  • Author(s): *二川健
  • Organizer: 第29回泌尿器科分子・細胞研究会
  • Invited
• [Presentation] 国際宇宙ステーション実験からえたUnloadingによる筋萎縮の分子メカニズム (2020)
  • Author(s): *二川健
  • Organizer: 第18回糖尿病運動療法研究会 2nd STAGE
  • Invited
• [Presentation] 寝たきりや無重力による筋萎縮の分子メカニズムとその栄養学的予防法の開発 (2020)
  • Author(s): *二川健
  • Organizer: 第6回京都リハビリテーション医学会学術集会
  • Invited
• [Presentation] On how to prepare and use GUVs: From an experimental aspect (2020)
  • Author(s): Kanta Tsumoto
  • Organizer: International Workshop on “Water Mediated Low-Dimensional Coulomb Systems” for Bilateral Joint Research Projects between JAPAN & SLOVENIA respectively supported by JSPS (Japan) and MESS (Slovenia)
  • Int'l Joint Research / Invited
• [Presentation] 中枢時計におけるバソプレシン産生ニューロンの機能 (2020)
  • Author(s): *三枝理博
  • Organizer: 第27回日本時間生物学会学術大会
  • Invited
• [Presentation] 両側前庭障害の診断と対策 (2020)
  • Author(s): 岩﨑真一
  • Organizer: 日本耳鼻咽喉科学会埼玉県地方部会
  • Invited
• [Presentation] 障害者の骨をどう守る？ (2020)
  • Author(s): 篠原正浩
  • Organizer: 理論免疫ワークショップ
  • Invited
• [Presentation] Carbon-ion Cancer Radiotherapy: Double-Strand DNA Break Distribution and Repair (2020)
  • Author(s): Dylan J. Buglewicz, Hirokazu Hirakawa, Akira Fujimori, Takamitsu Kato
  • Organizer: The 66th RRS Annual Meeting
  • Int'l Joint Research
• [Presentation] High LET-like radiation tracks at the distal side of accelerated Proton Bragg peak (2020)
  • Author(s): Dakota Horendeck, Kade Walsh, Hirokazu Hirakawa, Akira Fujimori, Hisashi Kitamura, Takamitsu Kato
  • Organizer: The 66th RRS Annual Meeting
  • Int'l Joint Research
• [Presentation] 病気を「知る」、「治す」ためのゲノム編集技術 (2020)
  • Author(s): *宮本達雄
  • Organizer: 広島大学タマチラボ
  • Invited
• [Presentation] 真菌とヒトの健康障害；宇宙を含めた環境管理の可能性 ～真菌と共生するための空気清浄の役割～ (2020)
  • Author(s): 槇村浩一
  • Organizer: 第339回クリーンテクノロジー研究会
  • Invited
• [Presentation] Does cancer progress faster in space? - My future plan of ISS-Kibo and Deep Space Gateway utilization experiments - (2020)
  • Author(s): Akihisa Takahashi
  • Organizer: The 10th International Society of Radiation Neurobiology Conference ISRN-2020
  • Int'l Joint Research
• [Presentation] Combined effects of radiation and microgravity on the normal brain (2020)
  • Author(s): Yukari Yoshida, Espinosa-Jeffrey Araceli, Fernandez-Quezada David, Luquin de Anda Sonia, Akihisa Takahashi
  • Organizer: The 10th International Society of Radiation Neurobiology Conference ISRN-2020
  • Int'l Joint Research
• [Presentation] 放射線生物学における低酸素バイオロジー (2020)
  • Author(s): 原田浩
  • Organizer: 第49回京都放射線腫瘍研究会
  • Invited
• [Presentation] 低酸素と放射線の関わり (2020)
  • Author(s): 原田浩
  • Organizer: 第10回JASTRO放射線生物学セミナー
  • Invited
• [Presentation] Quantitative evaluation of the NBS1 I171V variant on radiosensitivity (2020)
  • Author(s): Tomioka K, Fujita K, Akutsu SN, Tauchi H, Yamamoto T, Kobayashi M, Kudo Y, Miyamoto T, *Matsuura S.
  • Organizer: The 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research
• [Presentation] DNA 損傷応答に対する模擬宇宙環境の影響 (2020)
  • Author(s): 大泉昂之、山邉聡一郎、山之内佐久也、舟山和夫、高橋昭久、中村麻子
  • Organizer: 茨城大学理学部公開シンポジウム第13回Quantum Medicine研究会
  • Invited
• [Presentation] Relationship between endogenous ROS accumulation and mitochondria responses under low dose rate irradiation (2020)
  • Author(s): Kobayashi J*, Meng Q., Komatsu K.
  • Organizer: The 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research
• [Presentation] 毛細血管拡張性運動失調症とATMキナーゼの役割 (2020)
  • Author(s): 小林純也*
  • Organizer: 第13回Quantum Medicine研究会
  • Invited
• [Presentation] Recommendations for space radiation research (2020)
  • Author(s): Akihisa Takahashi
  • Organizer: 第13回Quantum Medicine
  • Invited
• [Presentation] A novel hypoxia-inducible secretory protein, HISP2, causes radioresistance of hypoxic cancer cells in an autocrine manner (2020)
  • Author(s): Suwa T, Shirai Y, Kobayashi M, Mizowaki T, Harada H
  • Organizer: Keystone Symposia; (Hypoxia: Molecules, Mechanisms and Disease)
  • Int'l Joint Research
• [Presentation] A novel activator of HIF-1, ZBTB2, promotes invasion and growth of p53-deficient cancers (2020)
  • Author(s): Koyasu S, Harada H
  • Organizer: Keystone Symposia; (Hypoxia: Molecules, Mechanisms and Disease)
  • Int'l Joint Research
• [Presentation] RNA sequencing of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity (2020)
  • Author(s): Akihisa Takahashi, Hiroko Ikeda, Masafumi Muratani, Jun Hidema, Keigi Fujiwara, Hikaru Souda, Yukari Yoshida, Megumi Hada
  • Organizer: 2020 NASA Human Research Program Investigators’ Workshop
  • Int'l Joint Research
• [Presentation] Increased chromosome aberrations in lymphoblastoid cells exposed simultaneously to simulated microgravity and radiation (2020)
  • Author(s): Sakuya Yamanouchi, Jordan Rhone, Akihisa Takahashi, Megumi Hada
  • Organizer: 2020 NASA Human Research Program Investigators’ Workshop
  • Int'l Joint Research
• [Presentation] Increased protein phosphorylation and actin dynamics as early response in cells exposed to gravity changes. (2020)
  • Author(s): Keigi Fujiwara, Akihisa Takahashi, J. Wang, Z. Ju, Yukari Yoshida, Sakuya Yamanouchi, Megumi Hada
  • Organizer: 2020 NASA Human Research Program Investigators’ Workshop
  • Int'l Joint Research
• [Presentation] Plant culture system as a water recycling device in space farming (2020)
  • Author(s): Y. Kitaya
  • Organizer: JpGU Meeting 2020, A-OS25 陸域海洋相互作用-惑星スケール物質循環 Continental-Oceanic Mutual Interaction: Planetary scale Material Circulation
  • Int'l Joint Research
• [Presentation] 細胞の個性を理解するための技術開発 Observing heterogeneity in cell society (2020)
  • Author(s): Asako Sakaue-Sawano, Atsushi Miyawaki
  • Organizer: 第10回国際放射線神経生物学会大会
  • Int'l Joint Research / Invited
• [Presentation] Unique adaptation strategies to extreme stresses in tardigrades (2020)
  • Author(s): Kunieda T.
  • Organizer: Royal Society Theo Murphy international scientific meeting "Anhydrobiosis - cheating death and telling the tale"
  • Int'l Joint Research / Invited
• [Presentation] Implication of SAHS proteins in alleviation of oxidative stress in extracellular space. (2020)
  • Author(s): Tanaka A and Kunieda T.
  • Organizer: Royal Society Theo Murphy international scientific meeting "Anhydrobiosis - cheating death and telling the tale"
  • Int'l Joint Research
• [Presentation] Molecular and biophysical mechanisms of substrate rigidity sensing that determines cell fate (2019)
  • Author(s): M Sokabe*, T Kobayashi
  • Organizer: 第42回日本分子生物学会年会 シンポジウム2PS-01 Functions and Mechanisms of Force in Animal and Plant Live
  • Invited
• [Presentation] Functional space foods improve the QOL in moon village (2019)
  • Author(s): *Takeshi Nikawa
  • Organizer: The 3rd International Moon Village Workshop & Symposium
  • Int'l Joint Research
• [Presentation] Establishing an international institute for the development of next-generation space nutrition researchers (2019)
  • Author(s): *Takeshi Nikawa
  • Organizer: The 3rd International Moon Village Workshop & Symposium
  • Int'l Joint Research
• [Presentation] 第一回きぼうマウスミッション概要と成果 (2019)
  • Author(s): 高橋 智
  • Organizer: 薬物動態学会
  • Int'l Joint Research / Invited
• [Presentation] 国際宇宙ステーション（ISS）「きぼう」実験棟でのマウス宇宙実験の概要 (2019)
  • Author(s): 高橋 智
  • Organizer: 東北実験動物研究会
  • Invited
• [Presentation] ツメガエル胚の領域規定における細胞張力・細胞形状の関与 (2019)
  • Author(s): 道上達男
  • Organizer: 第5回幹細胞研究会
  • Invited
• [Presentation] Aqueous/Aqueous Microdroplets: Their Stability and Reactivity with Biomacromolecules (2019)
  • Author(s): Kanta Tsumoto*, Yusuke Fujise, Hiroki Sakuta, Kingo Takiguchi, Kenichi Yoshikawa, Masahiro Tomita
  • Organizer: OKINAWA COLLOIDS 2019 [S5] Science & Technologies for the Sustainable Space Colony Life
  • Int'l Joint Research
• [Presentation] Cooperation between DNA and Actin in Cell-Sized Aqueous/Aqueous Micro Droplet (2019)
  • Author(s): Hiorki Sakuta, Masahito Hayashi, Kingo Takiguchi, Kanta Tsumoto, Kenichi Yoshikaw*
  • Organizer: OKINAWA COLLOIDS 2019 [S3] Membranous and Membraneless Interfaces: Towards Artificial Cellular Complexity
  • Int'l Joint Research
• [Presentation] he neural circuit for prey capture in zebrafish: from visual stimuli to the hypothalamic feeding center (2019)
  • Author(s): Koichi Kawakami, Akira Muto
  • Organizer: Cold Spring Harbor Laboratory Meeting
  • Int'l Joint Research
• [Presentation] Analysis of tooth replacement mechanism using genetically modified medaka fish (2019)
  • Author(s): *Chatani M, Azetsu Y, Dodo Y, Sakai N, Kudo A, Takami M
  • Organizer: 第61回歯科基礎医学会学術大会
  • Int'l Joint Research / Invited
• [Presentation] 細胞も相分離してるんです～複雑な内部構造の起源に迫る～ (2019)
  • Author(s): 湊元幹太*
  • Organizer: 日本化学会秋季事業 第9回 CSJ化学フェスタ2019
  • Invited
• [Presentation] 初期胚の神経領域規定における物理的な力の関与 (2019)
  • Author(s): 道上達男
  • Organizer: 第14回日本臨床ストレス応答学会
  • Invited
• [Presentation] 神経から筋・代謝へのメカノストレス伝達と適応応答 (2019)
  • Author(s): 東谷篤志、Surabhi Sudevan、 東谷 なほ子、橋爪 藤子、東端 晃
  • Organizer: 第33回大会 日本宇宙生物科学会 特別シンポジウム
  • Invited
• [Presentation] メダカの宇宙適応を基盤とした骨研究 (2019)
  • Author(s): 茶谷 昌宏
  • Organizer: 日本宇宙生物科学会 第33回大会
  • Invited
• [Presentation] 機能性宇宙食の開発 (2019)
  • Author(s): 二川健
  • Organizer: 第66回日本栄養改善学会学術総会
  • Invited
• [Presentation] パネルディスカッション（1）「きぼう・こうのとり 成果と今後の展望（仮）」 (2019)
  • Author(s): 高橋 智
  • Organizer: きぼう・こうのとり10周年記念公開シンポジウム開催
  • Invited
• [Presentation] 廃用性筋萎縮の分子メカニズムとその栄養学的予防法 (2019)
  • Author(s): 二川健
  • Organizer: 第5回Neo VitamineD Workshop学術集会
  • Invited
• [Presentation] 無重力や寝たきりによる筋萎縮に有効な機能性宇宙食の開発 (2019)
  • Author(s): 二川健
  • Organizer: 日本食品科学工業会 第66回大会
  • Invited
• [Presentation] Self-Emerging Cooperative Localization of DNA and Actin in Cell-Sized Aqueous/Aqueous Droplet (2019)
  • Author(s): H Sakuta, M Hayashi, K Takiguchi, K Tsumoto, K Yoshikawa
  • Organizer: 12thEBSA and 10th ICBP-IUPAP Biophysics Congress
  • Int'l Joint Research
• [Presentation] Practicalities of sending C. elegans to space and the similarities of the worm’s adaptations to spaceflight and ageing. (2019)
  • Author(s): Atsushi Higashitani.
  • Organizer: 22nd International C. elegans Conference
  • Int'l Joint Research / Invited
• [Presentation] Ca2+ overload due to mitochondrial dysfunction causes muscle ECM degradation. (2019)
  • Author(s): Surabhi Sudevan, Mai Takiura, Yukihiko Kubota, Nahoko Higashitani, Michael Cooke, Rebecca A Ellwood, Timothy Etheridge, Nathaniel J Szewczyk, Atsushi Higashitani
  • Organizer: the 22nd International C. elegans Conference
  • Int'l Joint Research
• [Presentation] Bridging the Physiologic Gap: Using C. elegans to Improve Human Skeletal Muscle Health (2019)
  • Author(s): Atsushi Higashitani
  • Organizer: the 22nd International C. elegans Conference
  • Int'l Joint Research / Invited
• [Presentation] Metabolic flow from glycolysis to TCA cycle is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice (2019)
  • Author(s): Shimpei Hori, Yosuke Hiramuki, Daigo Nishimura, Fuminori Sato, Atsuko Sehara-Fujisawa
  • Organizer: 2019 Myogenesis Gordon Research Conference
  • Int'l Joint Research
• [Presentation] Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells. (2019)
  • Author(s): Takayuki Uchida, Yoshihiro Sakashita, Katsuya Hirasaka, Ayako Ohno, Reiko Nakao, Akira Higashibata, Takeshi Kobayashi, Masahiro Sokabe, Takeshi Nikawa
  • Organizer: ADVANCED BIOMEDICAL ENGINEERING AND INSTRUMENTATION SUMMIT
  • Int'l Joint Research
• [Presentation] Roles of a transcription factor 19A intheosteoblastdevelopmentof sternum (2019)
  • Author(s): Mao KURIKI, Fuminori SATO, Kenta SUMIYAMA, Kouichi KAWAKAMI, Atsuko SEHARA-FUJISAWA
  • Organizer: ECTS(European Calcified Tissue Society)2019
  • Int'l Joint Research
• [Presentation] Impact of space flight or simulated microgravity combined with space radiation exposure on retinal oxidative damage (2019)
  • Author(s): X. W. Mao, Marjan Boerma, George Nelson, Dai Shiba, Masaki Shirakawa, Satoru Takahashi, Michael Delp
  • Organizer: The International Society for Gravitational Physiology（ISGP）2019
  • Int'l Joint Research
• [Presentation] 無重力によるミトコンドリア機能異常と筋萎縮 (2019)
  • Author(s): 二川健
  • Organizer: 第92回日本整形外科学会学術総会
  • Invited
• [Presentation] Artificial membranes presenting membrane proteins delivered by revombinant baculovirus particles (2019)
  • Author(s): Kanta Tsumoto, Kohei Nakanishi, Seiwa Nishio and Masahiro Tomita
  • Organizer: The 7th Chaina-Japan Symposium on Nanomedicine
  • Int'l Joint Research / Invited
• [Presentation] Transposon-mediated genetic methods in zebrafish and their applications to the study of functional neural circuits (2019)
  • Author(s): Koichi Kawakami
  • Organizer: The first internationall zebrafish workshop in Qatar
  • Int'l Joint Research / Invited
• [Presentation] 難治性掻痒症治療薬ナルフラフィンの研究・開発とオレキシン受容体拮抗薬の設計・合成 (2019)
  • Author(s): 長瀬博
  • Organizer: 富山大学大学院生命融合科学教育部 特別講演会
  • Invited
• [Presentation] Effects of the gene expression of hypothalamic feeding-regulating neuropeptides after being exposed to different gravity in mice via vestibular inputs (2019)
  • Author(s): Satomi Sonoda, Mitsuhiro Yoshimura, Kazuhiko Baba, Kenya Sanada, Kazuaki Nishimura, Haruki Nishimura, Kentaro Tanaka, Takashi Maruyama, Chikara Abe, Hironobu Morita, *Yoichi Ueta
  • Organizer: Neuroscience of Energy Balance 2019
  • Int'l Joint Research
• [Presentation] モデルマウスを用いた骨融解症の病態理解 ー遺伝子欠損から疾患変異へー (2019)
  • Author(s): 綱川 祐貴, 篠原 正浩
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] 環境因子が影響する難聴の予知・予防法の解析 (2019)
  • Author(s): 大神信孝
  • Organizer: 第29回日本医療薬学会年会 公募シンポジウム 「難病治療における薬剤師の関わり ～根治療法のない疾患に薬剤師はどう向き合うのか?～
  • Invited
• [Presentation] 教育講演：宇宙で快適に生きるために：前庭系の可塑的変化 (2019)
  • Author(s): *森田啓之
  • Organizer: 第72回日本自律神経学会
  • Invited
• [Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology (2019)
  • Author(s): Hiroshi Nagase
  • Organizer: Novel Pain Therapeutics: From Basic Research to Clinical Translation and Rehabilitation
  • Int'l Joint Research / Invited
• [Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology (2019)
  • Author(s): Hiroshi Nagase
  • Organizer: Roman Pharmacists Association
  • Int'l Joint Research / Invited
• [Presentation] Time-series change in interpersonal relationships and mental health: 15-days confinement study in Japan. (2019)
  • Author(s): Yuichi Oi, Go Suzuki, Shotaro Doki, Shin-ichiro Sasahara, Ichiyo et al.
  • Organizer: International Astronautical Congress 2019 (IAC2019)
  • Int'l Joint Research
• [Presentation] Genetic dissection of the neural network of central circadian clock (2019)
  • Author(s): Michihiro Mieda
  • Organizer: 日本時間生物学会
• [Presentation] Gravity change and muscle/bone relationship. (2019)
  • Author(s): *Hiroshi Kaji.
  • Organizer: Japan-Korea Joint Symposium:第37回日本骨代謝学会第21回日本骨粗鬆症学会合同学術集会
• [Presentation] Welcomeセミナー：重力生理学：動物実験から被験者実験へ (2019)
  • Author(s): *森田啓之
  • Organizer: 第53回日本実験動物技術者協会総会
  • Invited
• [Presentation] 再生筋線維の肥大応答性を制御するエピジェネティック機構 (2019)
  • Author(s): 河野 史倫
  • Organizer: 第74回日本体力医学会大会
• [Presentation] Essential structure of orexin 1 receptor antagonist YNT-707 (2019)
  • Author(s): Sayaka Ohrui, Naoshi Yamamoto, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, *Hiroshi Nagase
  • Organizer: 27th International Society of Heterocyclic Chemistry Congress
• [Presentation] Different effects of orexin receptor antagonist and GABAA?agonist on physical and cognitive functions after forced awakening. (2019)
  • Author(s): J. Seol, Y. Fujii, I. Park, Y. Suzuki, F. Kawana, K. Yajima, S. Fukusumi, T. Okura, M. Satoh, K. Tokuyama, T. Kokubo, *M. Yanagisawa.
  • Organizer: World Sleep 2019
  • Int'l Joint Research
• [Presentation] オレキシン阻害薬とGABAA作動薬の服用が強制覚醒時における身体機能および認知機能に及ぼす影響 (2019)
  • Author(s): 薛載勲, 藤井悠也, 朴寅成, 鈴木陽子, 川名ふさ江, 矢島克彦, 福住昌司, 大藏倫博, 佐藤誠, 徳山薫平, 小久保利雄, *柳沢正史
  • Organizer: 第33回日本宇宙生物科学会
  • Invited
• [Presentation] Dynamic cerebral autoregulation during flexion and extension of the neck in healthy adults (2019)
  • Author(s): Tomokazu Kato, Toru Konishi, Takuya Kurazumi, Chiharu Takko, Yojiro Ogawa, Ken-ichi Iwasaki
  • Organizer: The ninth international meeting on Cerebral Haemodynamic Regulation (CARNet meeting) in collaboration with International Symposium on Intracranial Pressure and Neuromonitoring 2019
  • Int'l Joint Research
• [Presentation] 前庭系を介する自律神経調節 (2019)
  • Author(s): 安部 力
  • Organizer: 新学術領域 温度を基軸とした生命現象の統合的理解（温度生物学） 若手の会
  • Invited
• [Presentation] Possibility of anti-inflammatory effect via the vestibular system (2019)
  • Author(s): 安部 力
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] 筋・骨連関とマイオカイン. (2019)
  • Author(s): 梶博史.
  • Organizer: 第5回日本筋学会学術集会. シンポジウム４ 筋と他臓器との連関.
  • Invited
• [Presentation] Noisy galvanic vestibular stimulation as a treatment for bilateral vestibulopathy. (2019)
  • Author(s): Iwasaki S
  • Organizer: 3rd Seoul National University Bundang Hospital Dizziness Center Symposium
  • Int'l Joint Research / Invited
• [Presentation] 世界初のOX2R作動薬YNT-185の創出とその薬理作用 (2019)
  • Author(s): 長瀬博
  • Organizer: 第13回日本緩和医療薬学会年会
  • Invited
• [Presentation] 独創的新薬の開発を目指して (2019)
  • Author(s): 長瀬博
  • Organizer: 東京理科大学大学院基礎工学研究科 招待講演
  • Invited
• [Presentation] モルヒナン骨格を基盤とする研究開発（独創的新薬の開発を目指して） (2019)
  • Author(s): 長瀬博
  • Organizer: 日本薬学会中国四国支部 特別講演会
  • Invited
• [Presentation] オレキシン受容体選択的リガンドの設計・合成とその薬理作用 (2019)
  • Author(s): 長瀬博
  • Organizer: 2019年度東北医科薬科大学創薬研究センターシンポジウム
  • Invited
• [Presentation] Structured Review: Psychosocial Stress during Long-term Stays in Space (2019)
  • Author(s): Shin-ichiro SASAHARA, Yuichi OI, Shotaro DOKI, Daisuke HORI, Yuh OHTAKI, Christina-Sylvia ANDREA, Tsukasa TAKAHASHI, Nagisa SHIRAKI, Yu IKEDA, Tomohiko IKEDA, Ryutaro IZUMI, Tamaki SAITO, Ichiyo MATSUZAKI
  • Organizer: ISTS
  • Int'l Joint Research
• [Presentation] C1 neurons mediate a stress-induced protection of acute kidney injury (2019)
  • Author(s): Chikara Abe
  • Organizer: International Symposium on Bio-CHAINs from Single Molecules to Highly Organized Systems
  • Int'l Joint Research / Invited
• [Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton (2019)
  • Author(s): Mao Amezawa, Jumpei Horiuchi, Tsuyoshi Saitoh, Yasuhiro Ogawa, Yukiko Ishikawa, Yoko Irukayama, Emi Hasegawa, Daichi Hayakawa, Yurie Watanabe, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Hiroaki Gouda, Takeshi Sakurai, Masashi Yanagisawa, Hiroshi Nagase
  • Organizer: The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
  • Int'l Joint Research
• [Presentation] Time Course of Changes in Cerebral Oxygen Saturation by NIRS and Cerebral Blood Flow Velocity by TCD under Mild +Gz Hypergravity (2019)
  • Author(s): Toru Konishi, Takuya Kurazumi, Tomokazu Kato, Chiharu Takko, Yojiro Ogawa, Ken-ichi Iwasaki
  • Organizer: 90th Aerospace Medical Association (AsMA) Annual Scientific Meeting
  • Int'l Joint Research
• [Presentation] Effects of certrifugation-induced hypergravity on the hypothalamic feeding-related neuropeptides gene expressions in mice via vestibular inputs. (2019)
  • Author(s): Yoichi Ueta, Satomi Sonoda, Mitsuhiro Yoshimura, Takashi Maruyama, Chikara Abe, Hironobu Morita
  • Organizer: 第40回国際重力生理学会・宇宙生命科学技術集会
  • Int'l Joint Research
• [Presentation] Thermoregulation through the glutamatergic neurons in vestibular nucleus complex (2019)
  • Author(s): Chikara Abe
  • Organizer: EB 2019
  • Int'l Joint Research
• [Presentation] モルヒナン骨格を基盤とする研究開発－独創的新薬の創出を目指して－ (2019)
  • Author(s): 長瀬博
  • Organizer: 有機合成化学協会関東支部ミニシンポジウム
  • Invited
• [Presentation] Radiation-protective abilities of DADS, a garlic oil component in X-ray irradiated mice. (2019)
  • Author(s): Tetsuo Nakajima, Yasuharu Ninomiya and Mitsuru Nenoi
  • Organizer: The 7th International Conference on Food Factors (ICoFF2019)
  • Int'l Joint Research
• [Presentation] A link between activation of HIF-1 and defect in p53 (2019)
  • Author(s): Harada H
  • Organizer: Precision Medicine Symposium, National Taiwan University
  • Int'l Joint Research / Invited
• [Presentation] Future Tasks for Plant Space Radiation Research Area (2019)
  • Author(s): Jun Hidema*
  • Organizer: Joint Workshop by GIMRT & "Kibo" Users' Network of JAXA & AIRC
  • Int'l Joint Research / Invited
• [Presentation] How to research about simulated space environments on the Earth (2019)
  • Author(s): Akihisa Takahashi
  • Organizer: International Conference on Mechanical, Electrical and Medical Intelligent System 2019
  • Int'l Joint Research / Invited
• [Presentation] Assessment of Cancer Risk from Radiation Hazard in Space (2019)
  • Author(s): Akihisa Takahashi
  • Organizer: The 3rd International Moon Village Workshop and Symposium
  • Int'l Joint Research
• [Presentation] 「マンモスを再生せよ」に見るゲノム編集 (2019)
  • Author(s): *宮本達雄
  • Organizer: 科学道100冊・サイエンスカフェ（東広島市産業振興課）
  • Invited
• [Presentation] 新規HIF-1活性化因子の発現スクリーニングで明らかになったHIF-1活性制御機構 (2019)
  • Author(s): 原田浩
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] Biological effects of high LET heavy ions in human blood lymphocytes and mouse cells (2019)
  • Author(s): P. Hande, D. Zeegers, S. Venkatesan, M. Seah, P. Velmurugan, S. Koh, S. Sethu, M. Jayapal, B. Banerjee, H. Hirakawa, C. Liu, R. Okayasu, A. Fujimori
  • Organizer: 第62回日本放射線影響学会大会
  • Invited
• [Presentation] Genomic and histopathological features of lung tumors in mice irradiated with different types of radiation (2019)
  • Author(s): 鈴木 健之, 山崎 隼輔, 岩田 健一, 山田裕, 森岡 孝満, 臺野 和広, 甘崎 佳子, 上西 陸美, 小川 真里, 島田 義也, 柿沼 志津子
  • Organizer: 65th Annual Radiation Research Society Meeting
  • Int'l Joint Research
• [Presentation] マウスのたまご、宇宙から帰る (2019)
  • Author(s): 柿沼志津子
  • Organizer: 日本放射線影響学会第62回大会
  • Invited
• [Presentation] Radioresistance of cells; Lessons from hypoxia biology (2019)
  • Author(s): Harada H. Title TBA. The 3rd isRTB. Suzhou, China. Nov. 28, 2019
  • Organizer: The 3rd isRTB
  • Int'l Joint Research / Invited
• [Presentation] 低酸素・腫瘍生物学研究で迫る癌治療増感 (2019)
  • Author(s): 原田浩
  • Organizer: 日本放射線腫瘍学会第32回学術大会
  • Invited
• [Presentation] Future Space Experiments for “Cancer Risk Assessment“ (2019)
  • Author(s): Akihisa Takahashi
  • Organizer: International Training Course on Carbon-ion Radiotherapy 2019
  • Int'l Joint Research / Invited
• [Presentation] まだまだ終わらない宇宙実験 (2019)
  • Author(s): 髙橋昭久
  • Organizer: 日本放射線影響学会第62回大会市民公開講座
  • Invited
• [Presentation] Expression Profile of Cell Cycle-related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity (2019)
  • Author(s): Akihisa Takahashi, Hiroko Ikeda, Masafumi Muratani, Jun Hidema, Megumi Hada, Keigi Fujiwara, Hikaru Souda, Yukari Yoshida
  • Organizer: 35th Annual Meeting of the American Society for Gravitational and Space Research
  • Int'l Joint Research
• [Presentation] Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation (2019)
  • Author(s): Megumi Hada, Jordan Rhone, Andrew J Beitman, Hiroko Ikeda, Ianik Plante, Hikaru Souda, Yukari Yoshida, Kathryn D Held, Keigi Fujiwara, Premkumar B Saganti, Akihisa Takahashi
  • Organizer: 35th Annual Meeting of the American Society for Gravitational and Space Research
  • Int'l Joint Research
• [Presentation] 宇宙でガンの進行は早まるか? (2019)
  • Author(s): 髙橋昭久
  • Organizer: 奈良県立医科大学招待講演
  • Invited
• [Presentation] 宇宙生存環境拡大のために：宇宙放射線と重力環境変化の複合影響研究 (2019)
  • Author(s): 髙橋昭久
  • Organizer: 京大定例オープンセミナー
  • Invited
• [Presentation] 放射線治療効果の予測に繋げる低酸素生物学研究 (2019)
  • Author(s): 原田浩
  • Organizer: 第57回日本癌治療学会学術集会
  • Invited
• [Presentation] 宇宙環境における植物放射線影響研究の今後の課題 (2019)
  • Author(s): 日出間純*，髙橋昭久
  • Organizer: マイクログラビティ応用学会第31回大会（JASMA31）
  • Invited
• [Presentation] 皮膚マイクロバイオーム：いかにしてマイクロバイオームと良い関係を構築するか (2019)
  • Author(s): 杉田 隆
  • Organizer: 第70回日本皮膚科学会中部支部総会
  • Invited
• [Presentation] ISS搭載凍結受精卵に対する宇宙放射線の影響 (2019)
  • Author(s): 柿沼 志津子, 鶴岡 千鶴, 塚本 智史, 鬼頭 靖司, 小久保 年章, 和田 彩子, 畠山 朋美, 島田 義也, 矢野 幸子, 鈴木 智美, 東端 晃, 多田 基紀, 鈴木 ひろみ, 嶋津 徹
  • Organizer: 日本宇宙生物科学会 第33回大会,
  • Invited
• [Presentation] 宇宙微小重力・高紫外線複合環境ストレスに対する植物の応答：宇宙実験に何を期待するのか？" (2019)
  • Author(s): 日出間純
  • Organizer: 日本宇宙生物科学会第36回大会
  • Invited
• [Presentation] 放射線と疑似微小重力複合影響：ヒト線維芽細胞における遺伝子発現解析 (2019)
  • Author(s): 佐藤文規, 呉泉, チェミンヨン, 髙橋昭久, 小林純也, 村谷匡史, 王梓, 藤田生水, 内田智子, 加藤充康, 谷垣文章, 東端晃, 今村聖実, 堀内映美, 川上浩一, 菅野純夫, 鈴木穣, 松崎文雄, 瀬原淳子
  • Organizer: 日本宇宙生物科学会第37回大会
  • Invited
• [Presentation] 「宇宙に生きる」ための宇宙放射線影響研究シナリオ (2019)
  • Author(s): 髙橋 昭久
  • Organizer: 日本宇宙生物科学会第33回大会
  • Invited
• [Presentation] Is gravity parameter necessary for cancer risk assessment in long-term manned space missions? (2019)
  • Author(s): Akihisa Takahashi
  • Organizer: 7th International Systems Radiation Biology Workshop
  • Invited
• [Presentation] Cancer cell dormancy behind therapy resistance and recurrence of hypoxic cancer cells (2019)
  • Author(s): 原田浩
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] A link between HIF-1 and defects in p53 under hypoxic stress (2019)
  • Author(s): Hiroshi HARADA
  • Organizer: 第78回日本癌学会学術総会
  • Invited
• [Presentation] BIOINDICATORS OF HEAVY ION EXPOSURES IN HUMAN LYMPHOCYTES: USE OF MOLECULAR CYTOGENETIC TECHNIQUES (2019)
  • Author(s): Dimphy ZEEGERS, Shriram VENKATESAN, Birendranath BANERJEE, Swaminathan SETHU, Manikandan JAYAPAL, Akira FUJIMORI, Ryuichi OKAYASU, Prakash HANDE*
  • Organizer: 第33回宇宙生物科学会
  • Invited
• [Presentation] Radiation exposure induces early onset of mouse precursor B-cell lymphoma with specific genomic aberrations (2019)
  • Author(s): Hirotaka Tachibana, Kazuhiro Daino, Takamitsu Morioka, Yi Shang, Atsuko Ishikawa, Mari Ogawa, Misuzu Fujita, Akira Matsuura, Hiroyuki Nogawa, Yoshiya Shimada, Shizuko Kakinuma
  • Organizer: 16th International Congress of Radiation Research
  • Int'l Joint Research
• [Presentation] Inhibitory effect of environmental enrichment on radiation-induced intestinal tumor in ApcMin/+ mice (2019)
  • Author(s): 横溝 真哉, 西村 まゆみ, 森岡 孝満, 西村 由希子, 柳原 啓見, 鶴岡 千鶴, Kazumasa Inoue, Masahiro Fukushi, 柿沼 志津子, 島田 義也
  • Organizer: 16th International Congress of Radiation Research
  • Int'l Joint Research
• [Presentation] Age-dependent effects of 2 MeV fast neutrons on induction of medulloblastoma in Ptch1 heterozygous mice (2019)
  • Author(s): Chizuru Tsuruoka, Mutsumi Kaminishi, Mayumi Shinagawa, Yi Shang, Yoshiko Amasaki, Yoshiya Shimada, Shizuko Kakinuma
  • Organizer: 16th International Congress of Radiation Research
  • Int'l Joint Research
• [Presentation] Whole-exome sequencing analysis to identify somatic mutations in radiation-induced rat mammary carcinomas (2019)
  • Author(s): Hitomi Moriyama, Kazuhiro Daino, Tatsuhiko Imaoka, Masaru Takabatake, Takamitsu Morioka, Atsuko Ishikawa, Kazumasa Inoue, Masahiro Fukushi, Yoshiya Shimada, Shizuko Kakinuma
  • Organizer: 16th International Congress of Radiation Research
  • Int'l Joint Research
• [Presentation] 宇宙での長期滞在：宇宙放射線とガン死リスク" (2019)
  • Author(s): 髙橋昭久
  • Organizer: 第一回探査の将来を考える勉強会
  • Invited
• [Presentation] Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect). ICRR. (2019)
  • Author(s): Bing Wang, Cuihua Liu, Kaoru Tanaka, Takanori Katsube, Hirokazu Hirakawa, Yasuharu Ninomiya, Kouichi Maruyama, Masahiro Murakami, Kazuko Fujita, Qiang Liu, Akira Fujimori, Mitsuru Nenoi.
  • Organizer: ICRR（International Congress of Radiation Research）
  • Int'l Joint Research
• [Presentation] Effects of chronic restraint-induced stress and Fe-particle irradiation on induction of chromosomal aberrations in Trp53-heterozygous mice. (2019)
  • Author(s): Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Cuihua Liu, Hirokazu Hirakawa, Kouichi Maruyama, Guillaume Vares, Qiang Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
  • Organizer: ICRR（International Congress of Radiation Research）
  • Int'l Joint Research
• [Presentation] Psychosocial stress promotes radiation-induced acute damage in mice (2019)
  • Author(s): Tetsuo Nakajima, Yasuharu Ninomiya, Keiko Unno, Takamitsu Morioka, Mayumi Nishimura, Mitsuru Nenoi and Shizuko Kakinuma
  • Organizer: ICRR（International Congress of Radiation Research）
  • Int'l Joint Research
• [Presentation] Radioresistance of hypoxic tumor cells (2019)
  • Author(s): Hiroshi HARADA
  • Organizer: The 16th International Congress for Radiation Research
  • Int'l Joint Research / Invited
• [Presentation] Novel hypoxia-inducible secretory protein, HISP2, cause radioresistance of cells in an autocrine manner (2019)
  • Author(s): Tatsuya SUWA, Minoru KOBAYASHI, Hiroshi HARADA
  • Organizer: The 16th International Congress for Radiation Research
  • Int'l Joint Research
• [Presentation] ゲノム編集技術を用いたオーファン繊毛病の病因・病態解明 (2019)
  • Author(s): 宮本達雄
  • Organizer: 愛知医科大学 病理学セミナー
  • Invited
• [Presentation] Evaluation of radioprotective effect of piceatannol (2019)
  • Author(s): Kenta Takahashi, Ryoya Tetsuka, Ryoichi Hirayama, Takashi Shimokawa, Tsutomu Shimura, Asako J. Nakamura
  • Organizer: 16th International Congress of Radiation Research
  • Int'l Joint Research
• [Presentation] The effect of simulated space environment on DNA damage response (2019)
  • Author(s): Takashi Oizumi, Souichiro Yamabe, Tomoo Funayama, Akihisa Takahashi, Asako J. Nakamura
  • Organizer: 16th International Congress of Radiation Research
  • Int'l Joint Research
• [Presentation] Ptch1ヘテロ欠損マウスの髄芽腫発生モデルの放射線シグネチャーを用いた 低線量率リスク解析 (2019)
  • Author(s): 鶴岡 千鶴, 森岡 孝満, 上西 睦美, 品川 まゆみ, 島田 義也, 柿沼 志津子, Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ
  • Organizer: アイソトープ・放射線研究発表会
  • Invited
• [Presentation] FISH analysis of chromosomal aberrations induced in?Trp53-heterozygous mice exposed to both?chronic?restraint-induced stress and Fe-particle irradiation. Workshop of Radiation Medicine and Protection (2019)
  • Author(s): Takanori Katsube, Bing Wang,?Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi?Maruyama, Guillaume Vares,?Qiang Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
  • Organizer: Workshop of Radiation Medicine and Protection
  • Invited
• [Presentation] New Progress in Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect) (2019)
  • Author(s): Bing Wang, Cuihua Liu, Kaoru Tanaka, Takanori Katsube, Hirokazu Hirakawa, Yasuharu Ninomiya, Kouichi Maruyama, Masahiro Murakami, Kazuko Fujita, Qiang Liu, Akira Fujimori, Mitsuru Nenoi.
  • Organizer: Workshop of Radiation Medicine and Protection
  • Invited
• [Presentation] がん抑制機構と低酸素応答機構をつなぐ新規遺伝子の同定と活用 (2019)
  • Author(s): 原田浩
  • Organizer: 京都大学大学院生命科学研究科シンポジウム
  • Invited
• [Presentation] Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-limb Unloading (2019)
  • Author(s): Akihisa Takahashi, Shoto Wakihata, Liqiu Ma, Takuya Adachi, Yukari Yoshida, Yoshinobu Ohira
  • Organizer: 32nd The International Symposium on Space Technology and Science (ISTS2019)
  • Int'l Joint Research
• [Presentation] 16S rDNA- and rRNA-based community structures of bacteria in the Japanese module ‘Kibo’ of the International Space Station (2019)
  • Author(s): Kimiko Uchii, Kenji Shiomi, Naohiro Enokida, Tomoaki Ichijo, Katsuji Tani, Masao Nasu
  • Organizer: 32nd ISTS
  • Int'l Joint Research
• [Presentation] Human microbes dominate in a pharmaceutical manufacturing facility as a model of space habitat (2019)
  • Author(s): Tomoaki Ichijo, Mako Kawai, Takashi Sugita, Masao Nasu
  • Organizer: 32nd ISTS
  • Int'l Joint Research
• [Presentation] CRISPR-ObLiGaRe法を用いたiPS細胞における蛍光核標識によるモザイク・トリソミー21のモデル細胞系の開発 (2019)
  • Author(s): Silvia Natsuko Akutsu、落合博、山本卓、大橋博文、宮本達雄、松浦伸也
  • Organizer: 日本ゲノム編集学会第4回大会
  • Int'l Joint Research / Invited
• [Presentation] Gunma University Heavy Ion Medical Center (GHMC): Therapy and Space Research? (2019)
  • Author(s): Akihisa Takahashi
  • Organizer: International Conference on Technology and Social Science 2019 (ICTSS 2019)
  • Int'l Joint Research / Invited
• [Presentation] Space Experiments for "Cancer Progression" in the International Space Station (2019)
  • Author(s): Akihisa Takahashi, Masafumi Muratani, Asako Sawano, Atushi Miyawaki
  • Organizer: 40th Annual International Society for Gravitational Physiology Meeting (ISGP2019)
  • Int'l Joint Research
• [Presentation] DIALLYL DISULFIDE AMELIORATES RADIATION DAMAGE IN CELLS AND MICE (2019)
  • Author(s): Tetsuo Nakajima, Guillaume Vares, Yasuharu Ninomiya, Bing Wang, Takanori Katsube, Kaoru Tanaka, Kouichi Maruyama, and Mitsuru Nenoi
  • Organizer: 国際ガーリックシンポジウム
  • Int'l Joint Research / Invited
• [Presentation] 極限環境に耐える動物クマムシから切り拓く新たな耐性メカニズム (2019)
  • Author(s): *國枝武和
  • Organizer: 第2回理研科学者会議セミナー
  • Invited
• [Presentation] 宇宙にも耐える！極限環境に耐える動物クマムシのサバイバル戦略を読み解く (2019)
  • Author(s): *國枝武和
  • Organizer: 第635回高崎研オープンセミナー
  • Invited
• [Presentation] Plant and fish growth and nitrogen flow in aquaponics integrated with lettuce hydroponics and loach aquaculture in vertical farming (2019)
  • Author(s): *Yoshiaki Kitaya, Yotsuba Shimakawa, Teruo Wada, Toshio Shibuya, Ryosuke Endo, Masumi Kikuch, Kenji Nakamura
  • Organizer: VertiFarm2019: Workshop on vertical farming
  • Int'l Joint Research
• [Presentation] 宇宙での食料生産・物質循環・健康維持機能を担う植物システムの構築 (2019)
  • Author(s): 北宅善昭
  • Organizer: 宇宙での食料生産・物質循環・健康維持機能を担う植物システムの構築「第４回探査の将来を考える勉強会」
  • Invited
• [Presentation] Visualization of Homeostatic Disturbances in Space (2019)
  • Author(s): *Asako Sakaue-Sawano and Atsushi Miyawaki
  • Organizer: Resonance Bio International Symposium (RBIS)
  • Int'l Joint Research
• [Presentation] Why do we fall asleep when bored - The gating of sleep by motivated behavior (2019)
  • Author(s): Michael Lazarus
  • Organizer: The 10th IBRO World Congress of Neuroscience
  • Int'l Joint Research / Invited
• [Presentation] Evolutionary analysis of UL7 phosphorylation events encoded by a-herpesviruses (2019)
  • Author(s): Misato Shibazaki, Akihisa Kato, Jumpei Ito, Mai Suganami, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Kei Sato and Yasushi Kawaguchi
  • Organizer: 第18回あわじしま感染症・免疫フォーラム
  • Int'l Joint Research
• [Presentation] 長期有人宇宙活動を支える植物 (2019)
  • Author(s): 北宅善昭
  • Organizer: 日本植物学会第83回大会 シンポジウム「宇宙から識る植物科学」
  • Invited
• [Presentation] Plant Factories Aiming at Recycling Material and Effectively Using Energy (2019)
  • Author(s): Yoshiaki, Kitaya, Ryosuke Endo, Katsumi Ohyama
  • Organizer: 2019 China Protected Agricultural Industry Conference & 2019 International Symposium on Environment Control Technology for Value-added Plant Production
  • Int'l Joint Research / Invited
• [Presentation] 極限環境に耐える動物クマムシの耐性戦略 (2019)
  • Author(s): 國枝武和
  • Organizer: 第38回分子病理研究会
  • Invited
• [Presentation] 単純ヘルペスウイルスの増殖・病態発現機構 (2019)
  • Author(s): 川口寧
  • Organizer: 第33回ヘルペスウイルス研究会
  • Invited
• [Presentation] Development of plant-based regenerative life support systems with sweetpotato culture in space (2019)
  • Author(s): Yoshiaki, Kitaya, Kengo Higashi, Toshio Shibuya, Ryosuke Endo
  • Organizer: 32nd International symposium on space technology and science (ISTS)
  • Int'l Joint Research
• [Presentation] Tricks enabling extremotolerance of tardigrades (2019)
  • Author(s): 國枝武和
  • Organizer: The MFPL international seminar
  • Int'l Joint Research / Invited
• [Presentation] Molecular Mechanisms of Herpes Simplex Virus Replication and Pathogenicity (2019)
  • Author(s): Yasushi Kawaguchi
  • Organizer: HARVARD MEDICAL SCHOOL Special Seminar
  • Int'l Joint Research / Invited
• [Presentation] Development of Space Pant Factories in Controlled Ecological Life Support Systems (2019)
  • Author(s): Yoshiaki, Kitaya
  • Organizer: 40th Annual Meeting of the International Society for Gravitational Physiology (ISGP) and Space Life Science and Medicine Meeting
  • Int'l Joint Research
• [Book] 酸素環境感知の基本メカニズムとがん (2020)
  • Author(s): 小林稔、*原田浩
  • Total Pages: 7
  • Publisher: 羊土社
  • ISBN: 978-4-7581-2532-1
• [Book] 第７章 宇宙植物工場の開発 第2 節 長期有人宇宙活動のための物質循環型植物工場 (2020)
  • Author(s): 北宅 善昭，遠藤 良輔
  • Total Pages: 7
  • Publisher: 技術情報協会
  • ISBN: 978-4-86104-817-3
• [Book] 機能性宇宙食の開発について (2019)
  • Author(s): 二川健
  • Total Pages: 6
  • Publisher: 篠原出版新社
  • ISBN: 978-4867057513
• [Book] 宇宙での物質循環型植物栽培システム (2019)
  • Author(s): 北宅善昭
  • Total Pages: 8
  • Publisher: 篠原出版新社
  • ISBN: 978-4-86705-751-3
• [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解
  • URL: https://living-in-space.jaxa.jp/
• [Patent(Industrial Property Rights)] 前庭刺激装置、めまい治療装置、健康促進装置 (2019)
  • Inventor(s): 加藤昌志、大神信孝、曽根三千彦、杉本賢文
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2018-104637号
• [Patent(Industrial Property Rights)] ALK2の異変を有する疾患の治療または予防用医薬組成物 (2019)
  • Inventor(s): 荒井宏行、瀬原淳子
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2019-134122号
• [Patent(Industrial Property Rights)] 血流促進装置、椅子、ベッド (2019)
  • Inventor(s): 加藤昌志、大神信孝
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2018-239849号
• [Patent(Industrial Property Rights)] がんを治療するための医薬組成物 (2019)
  • Inventor(s): 原田浩、子安翔
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2019-141624号
• [Patent(Industrial Property Rights)] DNA障害抑制剤 (2015)
  • Inventor(s): 國枝武和、橋本拓磨
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許6583606号