Cell Proliferation Control

2011 Fiscal Year Final Research Report

• Project Area: Cell Proliferation Control
• Project/Area Number: 19057004
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: KISHIMOTO Takeo 東京工業大学, 大学院・生命理工学研究科, 教授 (00124222)
• Co-Investigator(Kenkyū-buntansha): SAGATA Noriyuki 九州大学, 理学(系)研究科(研究院), 教授 (80142024) ; INAGAKI Masaki 愛知県がんセンター(研究所), 発がん制御研究部, 部長 (30183007) ; TAKEUCHI Takashi 鳥取大学, 医学部, 教授 (70197268)
• Research Collaborator: ASAJIMA Makoto 東京大学, 大学院・総合文化研究科, 特任教授 ; YAMAMOTO Tadashi 東京大学, 医科学研究所, 教授 ; MASAI Hisao 東京都医学研究機構, 副参事研究員
• Project Period (FY): 2007 – 2012
• Keywords: 細胞周期 / 細胞増殖 / 細胞分化 / 多細胞体制 / チェックポイント / サイクリン / CDK / CDKインヒビター

Research Abstract

Our research area aims to attain integrated understanding, using the cell cycle control as a key, on the molecular balance that switches between cell proliferation and cell differentiation. For this purpose, we organized the group meeting consisted of whole members of the research area once a year to promote exchange of unpublished results and research collaboration. Activity of the research area was announced through organizing 10 times of international conferences, maintaining homepage of our research area, and book-editing of our research field.

Research Products

• [Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells (2012)
  • Author(s): Inoko, A., Matsuyama, M., Goto, H., Ohmuro-Matsuyama, Y., Hayashi, Y., Enomoto, M., Ibi, M., Urano, T., Yonemura, S., Kiyono, T., Izawa, I., and Inagaki, M.
  • Journal Title: J. Cell Biol. Volume: 197 Pages: 391-405
• [Journal Article] Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt (2011)
  • Author(s): Hiraoka, D., Okumura, E., and Kishimoto, T.
  • Journal Title: Oncogene Volume: 30 Pages: 4487-4497
• [Journal Article] Dynamic regulation ofEmi2 by Emi2-bound Cdk1/Plk1/CK1 and PP2A-B56 in meiotic arrest of Xenopus eggs (2011)
  • Author(s): Isoda, M., Sako, K., Suzuki, K. Nishino, K., Nakajo, N., Ohe, M., Ezaki, T., Kanemori, Y., Inoue, D., Ueno, H., and Sagata, N.
  • Journal Title: Dev. Cell Volume: 21 Pages: 506-519
• [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonji (Jarid2)-cyclinD1 pathway (2011)
  • Author(s): Nakajima, K., Inagawa, M., Uchida, C., Okada, K., Tane, S., Kojima, M., Kubota, M., Noda, M., Ogawa, S, Shirato, H., Sato, M., Suzuki-Migishima, R., Hino, T., Satoh, Y., Kitagawa, M., and Takeuchi, T.
  • Journal Title: Development Volume: 138 Pages: 1771-1782
• [Journal Article] Nuclear Chk1 prevents premature mitotic entry (2011)
  • Author(s): Matsuyama, M., Goto, H., Kasahara, K., Kawakami, Y., Nakanishi, M., Kiyono, T., Goshima, N., and Inagaki, M.
  • Journal Title: J. Cell Sci. Volume: 124 Pages: 2113-2119
• [Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs (2010)
  • Author(s): Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., and Kishimoto, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Pages: 5006-5011
• [Journal Article] Emi2 inhibition of the APC/C absolutely requires Emi2 binding via the C-terminal RL tail (2010)
  • Author(s): Ohe, M., Kawamura, Y., Ueno, H., Inoue, D., Kanemori, Y., Senoo, C., Isoda, M., Nakajo, N., and Sagata, N.
  • Journal Title: Mol. Biol. Cell Volume: 21 Pages: 905-913
• [Journal Article] 14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage (2010)
  • Author(s): Kasahara, K., Goto, H., Enomoto, M., Tomono, Y., Kiyono, T., and Inagaki, M.
  • Journal Title: EMBO J. Volume: 29 Pages: 2802-2812
• [Journal Article] Start of theembryonic cell cycle is dually locked in unfertilized starfish eggs (2009)
  • Author(s): Hara, M., Mori, M., Wada, T., Tachibana, K., and Kishimoto, T.
  • Journal Title: Development Volume: 136 Pages: 1687-1696
• [Journal Article] The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF-TrCP-dependent degradation for cell-cycle arrest (2009)
  • Author(s): Isoda, M., Kanemori, Y., Nakajo, N., Uchida, S., Yamashita, K., Ueno, H., and Sagata, N.
  • Journal Title: Mol. Biol. Cell Volume: 20 Pages: 2186-2195
• [Journal Article] A Jumonji (Jarid2) Protein Complex Represses cyclin D1 Expression by Methylation of Histone H3-K9 (2009)
  • Author(s): Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., and Takeuchi, T.
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 733-739
• [Journal Article] Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during the G2/M transition (2009)
  • Author(s): Enomoto, M., Goto, H., Tomono, Y., Kasahara, K., Tsujimura, K., Kiyono, T., and Inagaki, M.
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 34223-34230
• [Journal Article] Cyclin B-Cdk1 controls pronuclear union in interphase (2008)
  • Author(s): Tachibana, K., Hara, M., Hattori, Y., and Kishimoto, T.
  • Journal Title: Curr. Biol. Volume: 18 Pages: 1308-1313
• [Journal Article] FoxM1-driven cell division is required for neuronal differentiation in early Xenopus embryos (2008)
  • Author(s): Ueno, H., Nakajo, N., Watanabe, M., Isoda, M., and Sagata, N.
  • Journal Title: Development Volume: 135 Pages: 2023-2030
• [Journal Article] The keratin-binding protein Albatross regulates polarization of epithelial cells (2008)
  • Author(s): Sugimoto, M., Inoko, A., Shiromizu, T., Nakayama, M., Zou, P., Yonemura, S., Hayashi, Y., Izawa, I., Sasoh, M., Uji, Y., Kaibuchi, K., Kiyono, T., and Inagaki, M.
  • Journal Title: J. Cell Biol. Volume: 183 Pages: 19-28
• [Journal Article] Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis (2007)
  • Author(s): Nishiyama, T., Yoshizaki, N., Kishimoto, T. and Ohsumi, K.
  • Journal Title: Nature Volume: 449 Pages: 341-345
• [Journal Article] A direct link of the Mos- MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus eggs (2007)
  • Author(s): Inoue, D., Ohe, M., Kanemori, Y., Nobui, T., and Sagata, N.
  • Journal Title: Nature Volume: 446 Pages: 1100-1104
• [Journal Article] Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain (2007)
  • Author(s): Takahashi, M., Kojima, M., Nakajima, K., Suzuki-Migishima, R., and Takeuchi, T.
  • Journal Title: Dev. Biol. Volume: 303 Pages: 549-560
• [Journal Article] Production of a site- and phosphorylation state-specific antibody (2007)
  • Author(s): Goto, H., and Inagaki, M.
  • Journal Title: Nat. Protoc. Volume: 2 Pages: 2574-2581
• [Presentation] Cooperation of Greatwall kinase with cyclin B-Cdk1 in starfish oocytes (2011)
  • Author(s): Kishimoto, T
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Ambleside, UK
  • Year and Date: 20110409-12
• [Presentation] Cell proliferation of mammalian cardiomyocytes and cardiac generation (2011)
  • Author(s): Takeuchi, T
  • Organizer: The 21st CDB Meeting "From regeneration biology to regenerative medicine"
  • Place of Presentation: RIKEN CDB, Kobe
  • Year and Date: 2011-11-24
• [Presentation] The Cell Cycle Control: Lessons from Starfish Oocytes (2010)
  • Author(s): Kishimoto, T
  • Organizer: Czech-Japan Jpoint Symposium "Animal Reproduction: From Gametes to Stem Cells"
  • Place of Presentation: Liblice, Czech Republic
  • Year and Date: 20100920-21
• [Presentation] Signaling pathway leading to meiotic maturation in starfish oocytes (2010)
  • Author(s): Kishimoto, T
  • Organizer: FHL International Symposium "Mechanisms of Egg Maturation and Fertilization: From Sea to Land"
  • Place of Presentation: Friday Harbor Laboratories, USA
  • Year and Date: 20100910-12
• [Presentation] Dual lock for cell cycle arrest in unfertilized mature starfish eggs (2009)
  • Author(s): Kishimoto, T
  • Organizer: Les Treilles Conference "Meiotic Division in Oocytes"
  • Place of Presentation: Les Treilles, France
  • Year and Date: 20090622-27
• [Presentation] Revisit to MPF (2008)
  • Author(s): Kishimoto, T
  • Organizer: Jacques Monod Conference "The cell cycle and genomic instability"
  • Place of Presentation: Roscoff, France
  • Year and Date: 20080426-30
• [Presentation] Cell cycle start after fertilization (2007)
  • Author(s): Kishimoto, T
  • Organizer: EMBO Workshop "Molecular Mechanisms of Cell Cycle Control in Normal and Malignant Cells": XIV European Cell Cycle Conference
  • Place of Presentation: Spetses, Greece
  • Year and Date: 20071005-08
• [Book] c-Mosによる卵子染色体半数化と単為発生の抑制「卵子学」(森崇英編) (2011)
  • Author(s): 立花和則、岸本健雄
  • Total Pages: 312-328
  • Publisher: 京都大学出版会
• [Book] Cytostatic arrest: Post-ovulation arrest until fertilization in metazoan oocytes. In "Oogenesis: The Universal Process" (ed. Verlhac, M.H.), Chapter 14 (2010)
  • Author(s): Nishiyama, T., Tachibana, K., and Kishimoto, T.
  • Total Pages: 357-384
  • Publisher: Wiley-Blackwell, UK.
• [Book] 細胞周期フロンティア (2010)
  • Author(s): 佐方功幸・稲垣昌樹・岸本健雄(編集)
  • Total Pages: 252
  • Publisher: 共立出版
• [Book] 細胞工学(1月号)特集「細胞周期研究の新たなステージ」 (2009)
  • Author(s): 岸本健雄(監修)
  • Total Pages: 1-58
  • Publisher: 秀潤社
• [Remarks] 特定領域「細胞増殖制御」ホームページ
  • URL: http://www.cellprolif.bio.titech.ac.jp/