2023 Fiscal Year Final Research Report
Support for the creation of the post-lysosomal biology research area.
| Project Area | Post-lysosome: Understanding of Higher-order Biological Processes initiated by the site of degradation |
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| Project/Area Number |
21H05144
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (III)
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| Research Institution | Nara Medical University (2023)
Osaka University (2021-2022) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤田 尚信 東京工業大学, 科学技術創成研究院, 准教授 (00506496)
吉川 治孝 徳島大学, 先端酵素学研究所, 助教 (60709567)
永沼 達郎 北海道大学, 薬学研究院, 助教 (60779619)
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| Project Period (FY) |
2021-08-23 – 2024-03-31
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| Keywords | リソソーム / プロテオミクス / リピドミクス |
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| Outline of Final Research Achievements |
In order to promote research on post-lysosome biology, the members of the project team worked in close collaboration with each other through the sharing of relevant information using slack and progress reports in web-based or face-to-face meetings once every three months. In addition, a total of three area meetings were held with advisors to obtain suggestions on the direction of research. Three jointly co-sponsored symposia were held at academic conferences to promote the activities of the field. Obtained results were published as peer-reviewed papers. Information on these activities was disseminated on the website (https://post-lysosome.jp/).
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢化社会に直面する先進諸国において健康寿命の延伸は喫緊の課題であり、ヒトにおいて老化の抑制を真に実現するには栄養因子などの環境的要因も含めた老化・寿命制御の確固たる分子メカニズムの理解が不可欠である。本領域活動を通して、この鍵を握ると考えられるポストリソソームシグナルの理解に一定の進展が見られた。今後得られた手がかりをもとに、様々なレベルのポストリソソームシグナルの作用機序解明を進めることで、将来的には健康寿命延伸の実現に向けた新たなシーズ創出につながる可能性がある。
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