Management of international relation and facility for promotion of research on sulfur biology

2022 Fiscal Year Annual Research Report

• Project Area: Life Science Innovation Driven by Supersulfide Biology
• Project/Area Number: 21H05258
• Research Institution: Tohoku University
• Principal Investigator: 本橋 ほづみ 東北大学, 加齢医学研究所, 教授 (00282351)
• Co-Investigator(Kenkyū-buntansha): 赤池 孝章 東北大学, 医学系研究科, 教授 (20231798) ; 澤 智裕 熊本大学, 大学院生命科学研究部(医), 教授 (30284756) ; 中林 孝和 東北大学, 薬学研究科, 教授 (30311195) ; 増田 真二 東京工業大学, 生命理工学院, 准教授 (30373369) ; 潮田 亮 京都産業大学, 生命科学部, 准教授 (30553367) ; 斎藤 芳郎 東北大学, 薬学研究科, 教授 (70357060) ; 花岡 健二郎 慶應義塾大学, 薬学部(芝共立), 教授 (70451854) ; 中川 秀彦 名古屋市立大学, 医薬学総合研究院(薬学), 教授 (80281674) ; 三木 裕明 京都大学, 工学研究科, 教授 (80302602) ; 和田 啓 宮崎大学, 医学部, 准教授 (80379304) ; 石丸 泰寛 東北大学, 工学研究科, 准教授 (80590207) ; 西田 基宏 九州大学, 薬学研究院, 教授 (90342641) ; 魏 范研 東北大学, 加齢医学研究所, 教授 (90555773)
• Project Period (FY): 2021-09-10 – 2026-03-31
• Keywords: 超硫黄分子 / 支援 / 国際交流

Outline of Annual Research Achievements

2022年8月に、第2回の総括班会議と、第３回の総括班会議を福岡の九州大学で実施した。コロナ禍ではあったが、感染対策を講じて、対面での開催としたことから、オンラインでは得られない濃厚な研究交流が実現し、公募研究の代表者も含めた領域内の共同研究が多数成立した。
バーチャルラボの実現のため、毎月１度、オンラインにより、すべての計画研究代表者と分担者、公募研究代表者、それぞれの研究室メンバーが参加する「領域プログレス」を実施している。研究室ごとの最新の実験結果を領域でシェアして、結果の解釈の議論、新たな実験の提案など、活発な意見交換がなされている。
2022年10月には、Redox Week in Sendai 2022を仙台の東北大学星陵キャンパスで開催し、久しぶりの対面での国際会議が実現した。レドックス生物学領域の第一線で活躍している研究者を世界各地から招聘し、本領域での研究成果を紹介した。我が国における硫黄生物学研究の先駆性に、世界の研究者が驚きを持って聞き入っている様子であった。
若手研究者の支援として、超硫黄分子の新しい測定技術を含む技術支援窓口・共同研究マッチング窓口の設置の準備をすすめ、領域としてのデータ管理、データシェアリング体制の構築の準備をすすめた。さらに、次年度に向けて、アウトリーチ活動の企画や、若手研究者を対象とした技術講習会の開催などについても運営の方法や時期などの検討を開始した。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

月例の領域プログレスでは、毎回100名近くの参加者があり、それぞれの研究室で試行錯誤をしながらすすめている超硫黄の検出や生物学的意義の検討などの情報を共有し、活発な共同研究の推進が可能になっている。2022年10月の国際会議では、多くの海外研究者との対面での交流ができたことから、実質的な共同研究の打ち合わせが多数展開し、国際的なグラント申請にも至っている。

Strategy for Future Research Activity

領域内の支援システムを稼働させて、超硫黄検出技術の普及に務める。今年度は、いろいろなデータが蓄積し始めると予想されるので、領域内のデータ管理、データシェアリングの体制も稼働させられるよう、準備をすすめる。また、若手研究者を対象にした技術トレーニングコースを実施し、超硫黄研究の研究者人口の増加と裾野拡大をはかる。

Research Products

• [Int'l Joint Research] NIH/University of Vermont(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: NIH/University of Vermont
• [Int'l Joint Research] Karolinska Institute(スウェーデン)
  • Country Name: SWEDEN
  • Counterpart Institution: Karolinska Institute
• [Int'l Joint Research] National Cancer Institute(ハンガリー)
  • Country Name: HUNGARY
  • Counterpart Institution: National Cancer Institute
• [Int'l Joint Research] University of Southampton/Queen Mary College, University of London(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: University of Southampton/Queen Mary College, University of London
• [Int'l Joint Research] University of Goettingen(ドイツ)
  • Country Name: GERMANY
  • Counterpart Institution: University of Goettingen
• [Journal Article] Contribution of NRF2 to sulfur metabolism and mitochondrial activity (2023)
  • Author(s): Alam Md Morshedul、Kishino Akihiro、Sung Eunkyu、Sekine Hiroki、Abe Takaaki、Murakami Shohei、Akaike Takaaki、Motohashi Hozumi
  • Journal Title: Redox Biology Volume: 60 Pages: 102624～102624
  • DOI: 10.1016/j.redox.2023.102624
  • Peer Reviewed / Open Access
• [Journal Article] Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics (2023)
  • Author(s): Shimizu Takayuki、Ida Tomoaki、Antelo Giuliano T、Ihara Yuta、Fakhoury Joseph N、Masuda Shinji、Giedroc David P、Akaike Takaaki、Capdevila Daiana A、Masuda Tatsuru
  • Journal Title: PNAS Nexus Volume: 2 Pages: -
  • DOI: 10.1093/pnasnexus/pgad048
  • Peer Reviewed
• [Journal Article] Thioredoxin-2 Regulates SqrR-Mediated Polysulfide-Responsive Transcription via Reduction of a Polysulfide Link in SqrR (2023)
  • Author(s): Shimizu Takayuki、Hashimoto Masaru、Masuda Tatsuru
  • Journal Title: Antioxidants Volume: 12 Pages: 699～699
  • DOI: 10.3390/antiox12030699
  • Peer Reviewed / Open Access
• [Journal Article] A non-nucleotide agonist that binds covalently to cysteine residues of STING (2023)
  • Author(s): Matsumoto Kentaro、Ni Shenwei、Arai Hiroyuki、Toyama Takashi、Saito Yoshiro、Suzuki Takehiro、Dohmae Naoshi、Mukai Kojiro、Taguchi Tomohiko
  • Journal Title: Cell Structure and Function Volume: 48 Pages: 59～70
  • DOI: 10.1247/csf.22085
  • Peer Reviewed / Open Access
• [Journal Article] Development of Nucleoside Diphosphate-Bearing Fragile Histidine Triad-Imaging Fluorescence Probes with Well-Tuned Hydrophobicity for Intracellular Delivery (2022)
  • Author(s): Kawaguchi Mitsuyasu、Furuse Yuri、Ieda Naoya、Nakagawa Hidehiko
  • Journal Title: ACS Sensors Volume: 7 Pages: 2732～2742
  • DOI: 10.1021/acssensors.2c01273
  • Peer Reviewed / Open Access
• [Journal Article] SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage (2022)
  • Author(s): Yamazaki Kosuke、Tahara Shinya、Ohyama Takumi、Kuroi Kunisato、Nakabayashi Takakazu
  • Journal Title: Scientific Reports Volume: 12 Pages: 11750～11750
  • DOI: 10.1038/s41598-022-15701-w
  • Peer Reviewed / Open Access
• [Journal Article] Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity (2022)
  • Author(s): Hoshino Yuki、Hanaoka Kenjiro、Sakamoto Kei、Yasunaga Masahiro、Kojima Takashi、Kotani Daisuke、Nomoto Ayumu、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Takamaru Hiroyuki、Saito Yutaka、Seto Yasuyuki、Urano Yasuteru
  • Journal Title: RSC Chemical Biology Volume: 3 Pages: 859～867
  • DOI: 10.1039/d1cb00253h
  • Peer Reviewed / Open Access
• [Journal Article] General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process (2022)
  • Author(s): Hanaoka Kenjiro、Iwaki Shimpei、Yagi Kiyoshi、Myochin Takuya、Ikeno Takayuki、Ohno Hisashi、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Uchigashima Motokazu、Mikuni Takayasu、Tainaka Kazuki、Tahara Shinya、Takeuchi Satoshi、Tahara Tahei、Uchiyama Masanobu、Nagano Tetsuo、Urano Yasuteru
  • Journal Title: Journal of the American Chemical Society Volume: 144 Pages: 19778～19790
  • DOI: 10.1021/jacs.2c06397
  • Peer Reviewed
• [Journal Article] Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs (2022)
  • Author(s): Shieh Meg、Ni Xiang、Xu Shi、Lindahl Stephen P.、Yang Moua、Matsunaga Tetsuro、Flaumenhaft Robert、Akaike Takaaki、Xian Ming
  • Journal Title: Redox Biology Volume: 56 Pages: 102433～102433
  • DOI: 10.1016/j.redox.2022.102433
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency (2022)
  • Author(s): Zhao Mingyue、Murakami Shohei、Matsumaru Daisuke、Kawauchi Takeshi、Nabeshima Yo-ichi、Motohashi Hozumi
  • Journal Title: The Journal of Biochemistry Volume: 171 Pages: 579～589
  • DOI: 10.1093/jb/mvac014
  • Peer Reviewed
• [Journal Article] CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells (2022)
  • Author(s): Okazaki Keito、Anzawa Hayato、Katsuoka Fumiki、Kinoshita Kengo、Sekine Hiroki、Motohashi Hozumi
  • Journal Title: The Journal of Biochemistry Volume: 171 Pages: 567～578
  • DOI: 10.1093/jb/mvac013
  • Peer Reviewed
• [Journal Article] Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress (2022)
  • Author(s): Kitamura Hiroshi、Oishi Tetsuya、Murakami Shohei、Yamada-Kato Tomoe、Okunishi Isao、Yamamoto Masayuki、Katori Yukio、Motohashi Hozumi
  • Journal Title: Free Radical Biology and Medicine Volume: 193 Pages: 610～619
  • DOI: 10.1016/j.freeradbiomed.2022.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Genetic, metabolic and immunological features of cancers with <scp>NRF2</scp> addiction (2022)
  • Author(s): Kitamura Hiroshi、Takeda Haruna、Motohashi Hozumi
  • Journal Title: FEBS Letters Volume: 596 Pages: 1981～1993
  • DOI: 10.1002/1873-3468.14458
  • Peer Reviewed / Open Access
• [Journal Article] Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage (2022)
  • Author(s): Liu Jun、Kasai Shuya、Tatara Yota、Yamazaki Hiromi、Mimura Junsei、Mizuno Seiya、Sugiyama Fumihiro、Takahashi Satoru、Sato Tsubasa、Ozaki Taku、Tanji Kunikazu、Wakabayashi Koichi、Maeda Hayato、Mizukami Hiroki、Shinkai Yasuhiro、Kumagai Yoshito、Tomita Hirofumi、Itoh Ken
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Pages: 3201～3201
  • DOI: 10.3390/ijms23063201
  • Peer Reviewed / Open Access
• [Journal Article] Green Tea Catechins, (?)‐Catechin Gallate, and (?)‐Gallocatechin Gallate are Potent Inhibitors of?ABA‐Induced Stomatal Closure (2022)
  • Author(s): Sato Kanane、Saito Shunya、Endo Kohsuke、Kono Masaru、Kakei Taishin、Taketa Haruka、Kato Megumi、Hamamoto Shin、Grenzi Matteo、Costa Alex、Munemasa Shintaro、Murata Yoshiyuki、Ishimaru Yasuhiro、Uozumi Nobuyuki
  • Journal Title: Advanced Science Volume: 9 Pages: 2201403～2201403
  • DOI: 10.1002/advs.202201403
  • Peer Reviewed / Open Access
• [Journal Article] Potassium transporter KUP9 participates in K+ distribution in roots and leaves under low K+ stress (2022)
  • Author(s): Yamanashi Taro、Uchiyama Takeshi、Saito Shunya、Higashi Taiki、Ikeda Hayato、Kikunaga Hidetoshi、Yamagami Mutsumi、Ishimaru Yasuhiro、Uozumi Nobuyuki
  • Journal Title: Stress Biology Volume: 2 Pages: 52～52
  • DOI: 10.1007/s44154-022-00074-x
  • Peer Reviewed / Open Access
• [Journal Article] GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity (2022)
  • Author(s): Sakurai Tsubasa、Kamakura Sachiko、Hayase Junya、Kohda Akira、Nakamura Masafumi、Sumimoto Hideki
  • Journal Title: Journal of Biological Chemistry Volume: 298 Pages: 102475～102475
  • DOI: 10.1016/j.jbc.2022.102475
  • Peer Reviewed / Open Access
• [Journal Article] Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells (2022)
  • Author(s): Tanemura Hiroki、Masuda Kenji、Okumura Takeshi、Takagi Eri、Kajihara Daisuke、Kakihara Hirofumi、Nonaka Koichi、Ushioda Ryo
  • Journal Title: Scientific Reports Volume: 12 Pages: 7239～7239
  • DOI: 10.1038/s41598-022-11342-1
  • Peer Reviewed / Open Access
• [Journal Article] TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation (2022)
  • Author(s): Kato Yuri、Nishiyama Kazuhiro、Man Lee Jae、Ibuki Yuko、Imai Yumiko、Noda Takamasa、Kamiya Noriho、Kusakabe Takahiro、Kanda Yasunari、Nishida Motohiro
  • Journal Title: International Journal of Molecular Sciences Volume: 24 Pages: 102～102
  • DOI: 10.3390/ijms24010102
  • Peer Reviewed / Open Access
• [Journal Article] Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors (2022)
  • Author(s): Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M
  • Journal Title: Nature Communications Volume: 13 Pages: 6374～6374
  • DOI: 10.1038/s41467-022-34194-9
  • Peer Reviewed / Open Access
• [Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress (2022)
  • Author(s): Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
  • Journal Title: Redox Biology Volume: 57 Pages: 102514～102514
  • DOI: 10.1016/j.redox.2022.102514
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of transient receptor potential cation channel?6 promotes capillary arterialization during post‐ischaemic blood flow recovery (2022)
  • Author(s): Numaga‐Tomita Takuro、Shimauchi Tsukasa、Kato Yuri、Nishiyama Kazuhiro、Nishimura Akiyuki、Sakata Kosuke、Inada Hiroyuki、Kita Satomi、Iwamoto Takahiro、Nabekura Junichi、Birnbaumer Lutz、Mori Yasuo、Nishida Motohiro
  • Journal Title: British Journal of Pharmacology Volume: 180 Pages: 94～110
  • DOI: 10.1111/bph.15942
  • Peer Reviewed / Open Access
• [Journal Article] A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia (2022)
  • Author(s): Shimauchi Tsukasa、Numaga-Tomita Takuro、Kato Yuri、Morimoto Hiroyuki、Sakata Kosuke、Matsukane Ryosuke、Nishimura Akiyuki、Nishiyama Kazuhiro、Shibuta Atsushi、Horiuchi Yutoku、Kurose Hitoshi、Kim Sang Geon、Urano Yasuteru、Ohshima Takashi、Nishida Motohiro
  • Journal Title: Cells Volume: 11 Pages: 2041～2041
  • DOI: 10.3390/cells11132041
  • Peer Reviewed / Open Access
• [Journal Article] Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression (2022)
  • Author(s): Nishiyama Kazuhiro、Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Kato Yuri、Shibata Takahiro、Tanaka Hiroshi、Kurose Hitoshi、Azuma Yasu-Taka、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Eaton Philip、Uchida Koji、Nishida Motohiro
  • Journal Title: Science Signaling Volume: 15 Pages: -
  • DOI: 10.1126/scisignal.abj0644
  • Peer Reviewed / Open Access
• [Journal Article] The Sulfide-Responsive SqrR/BigR Homologous Regulator YgaV of Escherichia coli Controls Expression of Anaerobic Respiratory Genes and Antibiotic Tolerance (2022)
  • Author(s): Balasubramanian Rajalakshmi、Hori Koichi、Shimizu Takayuki、Kasamatsu Shingo、Okamura Kae、Tanaka Kan、Ihara Hideshi、Masuda Shinji
  • Journal Title: Antioxidants Volume: 11 Pages: 2359～2359
  • DOI: 10.3390/antiox11122359
  • Peer Reviewed / Open Access
• [Journal Article] Persulfide-Responsive Transcription Factor SqrR Regulates Gene Transfer and Biofilm Formation via the Metabolic Modulation of Cyclic di-GMP in Rhodobacter capsulatus (2022)
  • Author(s): Shimizu Takayuki、Aritoshi Toma、Beatty J. Thomas、Masuda Tatsuru
  • Journal Title: Microorganisms Volume: 10 Pages: 908～908
  • DOI: 10.3390/microorganisms10050908
  • Peer Reviewed / Open Access
• [Journal Article] Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation (2022)
  • Author(s): Kaneko Takayuki、Mita Yuichiro、Nozawa-Kumada Kanako、Yazaki Masana、Arisawa Mieko、Niki Etsuo、Noguchi Noriko、Saito Yoshiro
  • Journal Title: Free Radical Research Volume: 56 Pages: 677～690
  • DOI: 10.1080/10715762.2023.2165918
  • Peer Reviewed / Open Access
• [Journal Article] Essential trace element selenium and redox regulation: its metabolism, physiological function, and related diseases (2022)
  • Author(s): Saito Yoshiro
  • Journal Title: Redox Experimental Medicine Volume: 2022 Pages: R149～R158
  • DOI: 10.1530/REM-22-0010
  • Peer Reviewed / Open Access
• [Journal Article] A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence (2022)
  • Author(s): Lohani Sweksha、Funato Yosuke、Akieda Yuki、Mizutani Kiyohito、Takai Yoshimi、Ishitani Tohru、Miki Hiroaki
  • Journal Title: Journal of Cell Science Volume: 135 Pages: -
  • DOI: 10.1242/jcs.258550
  • Peer Reviewed / Open Access
• [Journal Article] Phosphatase‐independent role of phosphatase of regenerating liver in cancer progression (2022)
  • Author(s): Funato Yosuke、Hashizume Osamu、Miki Hiroaki
  • Journal Title: Cancer Science Volume: 114 Pages: 25～33
  • DOI: 10.1111/cas.15625
  • Peer Reviewed / Open Access
• [Journal Article] The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters (2022)
  • Author(s): Funato Yosuke、Miki Hiroaki
  • Journal Title: Journal of Pharmacological Sciences Volume: 148 Pages: 14～18
  • DOI: 10.1016/j.jphs.2021.09.004
  • Peer Reviewed / Open Access
• [Presentation] Selenium biology and related diseases- application to the pandemic counterplan (2022)
  • Author(s): Yoshiro Saito
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research / Invited
• [Presentation] The physiological functions of cyclic octa-sulfur (S8) formed endogenously in diverse organisms including mammals (2022)
  • Author(s): Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research / Invited
• [Presentation] Cardiac ischemic stress resistance regulated by supersulfide (2022)
  • Author(s): Motohiro Nishida
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Nitrite and persulfide lowers blood pressure (2022)
  • Author(s): Martin Feelisch, Takaaki Akaike, Kayleigh Griffiths, Tomoaki Ida, Oleksandra Prysyazhna, Joanna Goodwin, Nicholas Gollop, Bernadette Fernandez, Magdalena Minion, Miriam Cortese-Krott, Alessandra Borgognone, Rosie Hayes, Philip Eaton, Michael Frenneaux, Melanie Madhani
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Cold plasma-irradiated cysteine attenuates aberrant sulfide metabolism induced by ischemia (2022)
  • Author(s): Kakeru Shimoda, Akiyuki Nishimura, Tomoaki Ida, Shota Sasaki, Tomohiro Tanaka, Toshiro Kaneko, Takaaki Akaike, Motohiro NishIda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Regulation of innate immune responses by reactive sulfur species (2022)
  • Author(s): Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Redox-dependent alternative internalization (REDAI) of GPCRs (2022)
  • Author(s): Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Yuri Kato, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Koji Uchida, Motohiro NishIda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] NRF2 addiction and sulfur metabolism in cancer cells (2022)
  • Author(s): Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Regulation of oncogenic protein PRL by diverse chemical modifications of its active cysteine (2022)
  • Author(s): Hiroaki Miki, Yosuke Funato
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Echinochrome enhances myocardial stress resistance by preserving reactive sulfur species (2022)
  • Author(s): Xiaokang Tang, Akiyuki Nishimura, Kazuhiro Nishiyama, Yuri Kato, Elena A Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Jin Han, Motohiro NishIda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Persulfide controls T cell response (2022)
  • Author(s): Shunichi Tayama, Takeshi Kawabe, Yuya Kitamura, Kyoga Hiraide, Jing Li, Ziying Yang, Kosuke Sato, Akihisa Kawajiri, Yuko Okuyama, Mitsuhiro Yamada, Masanobu Morita, Takaaki Akaike, Naoto Ishii
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Structural and functional analyses of the SUF system involved in de novo iron-sulfur cluster biosynthesis (2022)
  • Author(s): Kei Wada, Yoshikazu Tanaka, Yasuhiro Takahashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] S -nitrosyl L-cysteine acts as suicidal substrate of cystathionine gamma-lyase (2022)
  • Author(s): Shoma Araki, Yukihiro Tsuchiya, Shingo Kasamatsu, Hideshi Ihara, Hidehiko Nakagawa, Takaaki Akaike, Yasuo Watanabe
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Oligomer formation of peroxiredoxins by persulfidation (2022)
  • Author(s): Osamu Hashizume, Yosuke Funato, Hiroaki Miki
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Roles of sulfur metabolites in erythroid differentiation (2022)
  • Author(s): Eunkyu Sung, Shohei Murakami, Masanobu Morita, Tomoaki Ida, Takaaki Akaike, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Physiological roles of CARS2-mediated cysteine persulfide formation in the central nervous system (2022)
  • Author(s): Takaaki Suzuki, Shohei Murakami, Masanobu Morita, Tomoaki Ida, Takaaki Akaike, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Single cell multiomics reveals polysulfide-dependent regulation of hematopoietic stem cell differentiation (2022)
  • Author(s): Haruna Takeda, Shohei Murakami, Masanobu Morita, Takaaki Akaike, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Analysis of changes in sulfur metabolism in the brown adipose tissue of hibernation-induced golden hamsters (2022)
  • Author(s): Airi NishIda, Shingo Kasamatsu, Takaaki Akaike, Hideshi Ihara
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] The regulatory mechanism of photosynthetic activity by polysulfide (2022)
  • Author(s): Ayumu Kobayashi, Masaru Tsujii, Mio YoshIda, Haruto Shimizukawa, Minkyung Jung, Tomoaki Ida, Tsuyoshi Takata, Takaaki Akaike, Yasuhiro Ishimaru, Nobuyuki Uozumi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Identification of novel sulfur RNA modification and investigation of its possible functions in physiology and pathology (2022)
  • Author(s): Akiko Ogawa, Raja Norazireen Raja Ahmad, Tomohiro Sawa, Fan-Yan Wei
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Exploring the molecular basis of mitochondrial tRNA sulfur modification (2022)
  • Author(s): Haruna Tani, Fan-Yan Wei
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Omics analysis of reactive sulfur species in the brain tissue of mouse model of Alzheimer’s disease (2022)
  • Author(s): Ayaka Kinno, Shingo Kasamatsu, Takaaki Akaike, Hideshi Ihara
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Physiological functions of polysulfides produced by cysteinyl-tRNA synthetase 1 (CARS1) in skeletal muscle (2022)
  • Author(s): Yusuke Kusano, Shohei Murakami, Takahiro Onoki, Masanobu Morita, Tomoaki Ida, Yukio Katori, Takaaki Akaike, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Sulfur metabolism in cyclo-octasulfur S8-loaded 3T3-L1 adipocytes (2022)
  • Author(s): Yuka Unno, Tetsuro Matsunaga, Tsuyoshi Takata, Masanobu Morita, Minkyung Jung, Tomoaki Ida, Michito Yoshizawa, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Longevity regulation via sulfide: quinone oxidoreductasedependent energy metabolism in fission yeast (2022)
  • Author(s): Naim Hassan, Akira Nishimura, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Hiroshi Takagi, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Sulfide: quinone oxidoreductase produces cyclo-octasulfur, S8 that mediate sulfur respiration in mitochondria (2022)
  • Author(s): Tetsuro Matsunaga, Masanobu Morita, Tomoaki Ida, Akira Nishimura, Minkyung Jung, Tsuyoshi Takata1, Peter Nagy, Ming Xian, Motohiro Nishida, Michito Yoshizawa, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Discovery of new persulfide synthases that are expressed among all organisms during their evolution (2022)
  • Author(s): Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Tetsuro Matsunaga, Yuka Unno, Tsuyoshi Takata, Ayumu Kobayashi, Yasuhiro Ishimaru, Nobuyuki Uozumi, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] A novel mechanism of sulfur metabolism catalyzed by NOX and NOS (2022)
  • Author(s): Tsuyoshi Takata, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Minkyung Jung, Seiryo Ogata, Yuka Unno, Yukihiro Tsuchiya, Shohei Murakami, Yasuo Watanabe, Hozumi Motohashi, Michito Yoshizawa, Hideki Sumimoto, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Reactive sulfur species metabolism regulated by sulfurtransferase, rhodanese (2022)
  • Author(s): Akira Sato, Tsuyoshi Takata, Tetsuro Matsunaga, Masanobu Morita, Minkyung Jung, Tomoaki Ida, Michito Yoshizawa, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Chronological aging is regulated by persulfide production via mitochondrial cysteinyl-tRNA synthetase in yeas (2022)
  • Author(s): Sunghyeon Yoon, Akira Nishimura, Tomoaki Ida, Minkyung Jung, Tetsuro Matsunaga, Masanobu Morita, Hiroshi Takagi, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Antioxidative activity of human serum albumin via supersulfides (2022)
  • Author(s): Mayumi Ikeda, Maki Sakai, Keitaro Umezawa, Hidehiko Nakagawa, Toru Maruyama, Masaki Otagiri, Takaaki Akaike, Tomohiro Sawa, Ming Xian, Tatsuhiro IshIda, Yu Ishima
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Enhancement of tumor drug delivery using nitric oxide donors in advanced cancer (2022)
  • Author(s): Waliul Islam, Jun Fang, Hiroyasu Tsutsuki, Takuro Niidome, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Regulatory mechanism of NLRP3 inflammasome activation via protein S-sulfhydration (2022)
  • Author(s): Tianli Zhang, Hiroyasu Tsutsuki, Touya Toyomoto, Akiyuki Nishimura, Motohiro NishIda, Takaaki Akaike, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Host redox regulatory mechanisms involved in the pathogenicity of enterohemorrhagic Escherichia coli toxin SubAB (2022)
  • Author(s): Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Takaaki Akaike, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Polysulfide donor enhances bacteria killing by immune cells (2022)
  • Author(s): Azizur Rahman, Tianli Zhang, Hiroyasu Tsutsuki, Kei Miyano, Akira Yamauchi, Takaaki Akaike, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Inhibition of xCT, cystine/glutamate transporter, suppresses chronic inflammation in a mouse model of inflammatory bowel disease (2022)
  • Author(s): Hideya Iwaki1, Hiroki Sekine1, Shohei Murakami, Nobufumi Kato, Hiroshi Kitamura, Fanyan Wei, Shinji Fukuda, Tomonoshi Soga, Yoichi Kakuta, Atsushi Masamune, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Supersulfides negatively regulate type I interferon signaling (2022)
  • Author(s): Xiaoyan Li, Tianli Zhang, Hiroyasu Tsutsuki, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Reactive sulfur species regulate immune response via T cell receptor signaling (2022)
  • Author(s): Masanobu Morita, Mitsuhiro Yamada, Yusaku Sasaki, Tadahisa Numakura, Tomoaki Ida, Tetsuro Matsunaga, Tsuyoshi Takata, Satoshi Watanabe, Kenji Inaba, Naoto Ishii, Hisatoshi Sugiura, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Reactive sulfur species protect against SARS-CoV-2 infection via suppression of the viral thiol proteases (2022)
  • Author(s): Minkyung Jung, Tetsuro Matsunaga, Tomoaki Ida, Seiryo Ogata, Sunghyeon Yoon, Tsuyoshi Takata, Yuka Unno, Masanobu Morita, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Development and application of a visible-light-responsive NO releaser containing tellurorhodamine as an antenna (2022)
  • Author(s): Daisuke Saitoh, Naoya Ieda, Kyoya Oyama, Yuji Hotta, Mitsuyasu Kawaguchi,Kazunori Kimura, Hidehiko Nakagawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Development of 3-mercaptopyruvate sulfurtransferase (3MST) selective inhibitors and their inhibitory mechanism (2022)
  • Author(s): Kiyoshi Sasakura, Eita Sasaki, Kenjiro Hanaoka
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Development of ionization-coupled cleavage of oxidized polysulfide structure (iCOPS): a novel detection method for oxidized polysulfide modifications on proteins (2022)
  • Author(s): Kae Okamura, Shingo Kasamatsu, Takayuki Shimizu, Shinji Masuda, Hideshi Ihara
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Development of metabolomic diagnostics in mouse exhaled breath condensates (2022)
  • Author(s): Kenji Hamada, Shohei Murakami, Tomoaki Ida, Fanyan Wei, Kazuki Hayasaka, Yoshinori Okada, Takashi Kamei, Takaaki Akaike, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Breath omics technology developed for a hamster model of SARS-CoV-2 infection (2022)
  • Author(s): Seiryo Ogata, Masanobu Morita, Tetsuro Matsunaga, Tomoaki Ida, Shohei Murakami, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Breath omics analysis for the COVID-19: Viral PCR analysis and sulfur metabolome (2022)
  • Author(s): Seji Asamitsu, Seiryo Ogata, Tomoaki Ida, Tetsuro Matsunaga, Minkyung Jung, Tsuyoshi Takata, Masanobu Morita, Hozumi Motohashi, Takaaki Akaike
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs (2022)
  • Author(s): Meg Shieh, Xiang Ni, Stephen Lindahl, Shi Xu, Moua Yang, Tetsuro Matsunaga, Robert Flaumenhaft, Takaaki Akaike, Ming Xian
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] YgaV, a sulfide-responsive transcription factor SqrR/ BigR homolog of Escherichia coli, controls expression of anaerobic respiratory genes and antibiotic tolerance (2022)
  • Author(s): Rajalakshmi Balasubramanian, Shinji Masuda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Identification and quantification of β-lactam ring opened carbothioic S-acids mediated by cysteine hydropersulfide in bacteria (2022)
  • Author(s): Katsuhiko Ono, Hiroyasu Tsutsuki, Tianli Zhang, Takaaki Akaike, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Novel antibiotics adjuvant targeting bacterial cysteine synthase through enhancing oxidative stress (2022)
  • Author(s): Touya Toyomoto, Katsuhiko Ono, Hiroyasu Tsutsuski, Tianli Zhang, Takaaki Akaike, Tomohiro Sawa
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Selenoprotein P as a critical regulator of selenium metabolism- implication to iron metabolism (2022)
  • Author(s): Yoshiro Saito
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] The roles of sulfides in bone resorption (2022)
  • Author(s): Yoichi Miyamoto, Risa Sugisaki, Takaaki Akaike, Daichi Chikazu, Ryutaro Kamijo
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Physiological function of mitochondrial sulfur metabolism in hematopoietic stem cells (2022)
  • Author(s): Shohei Murakami, Zhao Mingyue, Masanobu Morita, Tomoaki Ida, Takaaki Akaike, Hozumi Motohashi
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Neutron structural analysis and computational chemistry reveal the control mechanism of the redox potential of 4Fe-4S type ferredoxin from Bacillus thermoproteolyticus (2022)
  • Author(s): Masaki Unno, Kenji Kobayashi, Iori Era, Yasutaka Kitagawa, Kei Wada
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] The EPR effect and beyond: Drug delivery for refractory cancer therapy via an endogenous albumin transport system (2022)
  • Author(s): Yu Ishima, Toru Maruyama, Takaaki Akaike, Masaki Otagiri, Tatsuhiro IshIda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Environmental stress-induced aberrant mitochondrial fission underlies cardiac vulnerability to mechanical load through Drp1 depolysulfidation (2022)
  • Author(s): Akiyuki Nishimura, Kakeru Shimoda, Xiaokang Tang, Kazuhiro Nishiyama, Yuri Kato, Yuko Ibuki, Takaaki Akaike, Yoshito Kumagai, Motohiro NishIda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Spatiotemporal control of NO release with caged NOs and their biological applications (2022)
  • Author(s): Hidehiko Nakagawa, Naoya Ieda
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Presentation] Development of fluorogenic probes for H2S and sulfane sulfur and their application to inhibitor screening (2022)
  • Author(s): Kenjiro Hanaoka
  • Organizer: Redox Week in Sendai 2022
  • Int'l Joint Research
• [Remarks] 新興硫黄生物学が拓く生命原理変革
  • URL: https://supersulfide-proj.com/
• [Funded Workshop] Redox Week in Sendai 2022 (2022)