2014 Fiscal Year Final Research Report
Multi-dimensional fluorescent live imaging of cellular functions and molecular activities
| Project Area | Mutli-dimensional fluorescence live imaging of cellular function and molecular activity |
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| Project/Area Number |
22113001
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAMURA Takeshi 愛媛大学, 医学(系)研究科(研究院), 教授 (70264421)
KIYOKAWA Etsuko 金沢医科大学, 医学部, 教授 (80300929)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAWAKI Atsushi 独立行政法人理化学研究所, 細胞機能探索技術開発チーム, チームリーダー (80251445)
NEMOTO Tomomi 北海道大学, 電子科学研究所, 教授 (50291084)
OKADA Takaharu 独立行政法人理化学研究所, 免疫細胞動態研究ユニット, ユニットリーダー (50452272)
ISHII Masaru 大阪大学, 大学院・生命機能研究科, 教授 (10324758)
FUKUHARA Shigetomo 独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (70332880)
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| Project Period (FY) |
2010-04-01 – 2016-03-31
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| Keywords | 蛍光イメージング / 蛍光タンパク質 / 蛍光プローブ / 細胞生物 / がん |
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| Outline of Final Research Achievements |
Recent progress of fluorescent live imaging is enormous. New fluorescent proteins with various optical properties and many fluorescent protein-bases probes with unique mode of actions have enabled us to visualize many cellular and molecular functions such as cell cycle status and activity of signaling molecules. The rapid evolution of fluorescent live imaging owes not only to the progress in the probes, but also to the development of microscopes based on a novel modality. The aim of this research project is to further promote the fluorescent live imaging, which allows researchers to observe cells, tissues, and animals in multiple dimensions. For this purpose, we annually held domestic workshop and organized three international symposia. For fostering young researchers, retreat named “vivid workshop” was held every year in the summer. More than 500 expression plasmids encoding fluorescent probes are distributed not only to domestic but also to foreign researchers.
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| Free Research Field |
細胞生物
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