Regeneration Biology guides real Regenerative Medicine

2014 Fiscal Year Final Research Report

• Project Area: Molecular mechanisms underlying reconstruction of 3D structers during regeneration
• Project/Area Number: 22124001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: AGATA Kiyokazu 京都大学, 理学(系)研究科(研究院), 教授 (70167831)
• Co-Investigator(Renkei-kenkyūsha): NOJI Sumihare 徳島大学, 理事 (40156211) ; UMESONO Yoshihiko 兵庫県立大学, 大学院生命理学研究科, 教授 (20391881) ; YOKOYAMA Hitoshi 弘前大学, 農学生命科学部, 准教授 (90455816) ; ENDO Tetsuya 愛知学院大学, 教養部, 准教授 (90399816) ; SHIBATA Norito 京都大学, 大学院理学研究科, 准教授 (60402781)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 再生 / 再生医療 / イモリ / カエル / プラナリア / コオロギ / 関節再生

Outline of Final Research Achievements

To gain insights to apply in human regenerative medicine to regenerate tissues/organs, we developed strategies to (1)Understand molecular bases of regeneration in highly regenerative animals such as planarian, cricket and newt. (2)Discover changes in Xenopus tadpole limb regeneration potential during transition from a regeneration-competent to a regeneration-incompetent stage, and provide this information to regeneration-incompetent animals via genetic manipulation to induce regeneration. (3)Establish novel clinical applications to replenish missing tissues/organs by inducing regeneration. We unraveled molecular mechanisms of planarian regeneration, and succeeded in inducing head regeneration from regeneration-incompetent planarians by genetic manipulation. We found a new principle of joint regeneration in newt, and applied it to succeed in evoking joint regeneration from regeneration-incompetent Xenopus. Thus, we opened doors to novel clinical strategies for regenerative medicine.

Free Research Field

理学