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2015 Fiscal Year Final Research Report

Regulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure

Administrative Group

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Project AreaRegulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
Project/Area Number 23112001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

Kikuchi Akira  大阪大学, 医学(系)研究科(研究院), 教授 (10204827)

Co-Investigator(Renkei-kenkyūsha) MINAMI YASUHIRO  神戸大学, 大学院医学研究科, 教授 (70229772)
OHNO SHIGEO  横浜市立大学, 大学院医学系研究科, 教授 (10142027)
SABE HISATAKA  北海道大学, 大学院医学系研究科, 教授 (40187282)
OHTANI HIROKI  島根大学, 医学部, 教授 (20160533)
SUZUKI ATSUSHI  九州大学, 生体防御医学研究所, 教授 (30415195)
OHASHI KAZUMASA  東北大学, 生命科学研究科, 准教授 (10312539)
TAKENAWA TADAOMI  神戸大学, 大学院医学研究科, 特命教授 (40101315)
MIYAJIMA ATSUSHI  東京大学, 分子細胞生物学研究所, 教授 (50135232)
HONDA HISAO  神戸大学, 医学研究科, 客員教授 (10289118)
Project Period (FY) 2011-04-01 – 2016-03-31
Keywords上皮菅腔組織形成 / 菅腔生物学 / 国際シンポジウム / 総括班
Outline of Final Research Achievements

Epithelial tubular tissues are essential structures of many organs, including lung, gut, kidney, exocrine glands, in multi-cellular organisms. The molecular mechanism underlying the regulation of cellular functions in an individual cell has been so far clarified. In the next decade the understanding of how cells form tissues or organs is one of the important issues in life science field. Moreover, research of diseases from the viewpoint of disruption of epithelial tubular tissues would contribute to solve various problems in medical science field. Therefore, we organized the research group that performs to clarify morphogenesis, remodeling, and breakdown of epithelial tubule structure. This five-year research program succeeded in demonstrating new results for the understanding of tubulogeneis and implication of its abnormality in diseases.

Free Research Field

生化学

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Published: 2017-05-10  

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