免疫四次元空間ダイナミクス

2013 Fiscal Year Annual Research Report

• Project Area: Analysis and synthesis of multi-dimensional immune organ network
• Project/Area Number: 24111001
• Research Institution: The University of Tokushima
• Principal Investigator: 高濱 洋介 徳島大学, 疾患プロテオゲノム研究センター, 教授 (20183858)
• Co-Investigator(Kenkyū-buntansha): 渡邊 武 京都大学, 医学(系)研究科(研究院), 特任教授 (40028684) ; 湊 長博 京都大学, 医学(系)研究科(研究院), 教授 (40137716) ; 宮坂 昌之 大阪大学, 医学(系)研究科(研究院), 名誉教授 (50064613) ; 高田 慎治 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 分子発生学研究部門, 教授 (60206753) ; 福井 宣規 九州大学, 生体防御医学研究所, 教授 (60243961) ; 長澤 丘司 京都大学, 再生医科学研究所, 教授 (80281690) ; 高木 淳一 大阪大学, たんぱく質研究所, 教授 (90212000)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 免疫学 / ストローマ細胞 / 免疫の場 / リンパ器官 / 免疫空間

Research Abstract

総括班として､活発かつ効率的に研究が進むように視点共有を図り､研究方針を企画調整するとともに､技術や材料の共有を支援し､助言と評価を行う｡また､班員間や科学者ｺﾐｭﾆﾃｨとの連携を促進し､研究領域の社会への定着と次世代研究者の育成を図る｡
この目的で､今年度は､総括班会議を二度､班会議を一度開催することで､公募研究班員を含め情報交換と視点共有を図り､総括班員と学術調査官による助言を得た｡それらを基盤に､関連領域を含む科学者ｺﾐｭﾆﾃｨとの連携を図り本領域の研究を国際的にｱﾋﾟｰﾙすべく､6月に第1回国際ｼﾝﾎﾟｼﾞｳﾑ「国際T細胞ﾜｰｸｼｮｯﾌﾟ」を開催し､海外17カ国の102名を含む294名の参加者を得た｡11月には第2回国際ｼﾝﾎﾟｼﾞｳﾑ「国際Synthetic Immunologyﾜｰｸｼｮｯﾌﾟ」を開催し約100名の参加者を得､2月には徳島大学国際免疫学ｼﾝﾎﾟｼﾞｳﾑを共催し82名の参加者を得た｡更に､京都大学と徳島大学で海外ﾘｰﾀﾞｰ研究者によるｾﾐﾅｰを計3回開催した｡加えて､研究領域の本邦定着と若手研究者の育成を目的に､7月に合宿形式のｻﾏｰｽｸｰﾙを開催し43名の参加を得た｡国民との対話活動については､日本免疫学会の科学ｺﾐｭﾆｹｰｼｮﾝ活動「免疫ふしぎ未来2013(日本科学未来館)」に参加し､ﾊﾟﾈﾙ展示やｼｮｰﾄﾄｰｸを通じ極めて多くの国民と双方向対話を行った（来場者2287名）｡また､骨髄ニッチFoxc1の同定､3Dﾊﾞｲｵﾌﾟﾘﾝﾀｰによる臓器作製､ｱﾙﾂﾊｲﾏｰ病原因物質の同定に関して､全国紙とﾆｭｰｽ番組で多数報道頂いた｡更に､北海道大学､東京理科大学､日本分子生物学会（神戸）で開催された市民公開活動に参加し国民との対話活動を行った｡科学者ｺﾐｭﾆﾃｨと一般社会に向けたｳｪﾌﾞｻｲﾄでは本年度､ﾆｭｰｽを79回掲載し12011回の来訪を得､班員の視点共有促進に寄与すべく開設した班員ﾌﾞﾛｸﾞでは年間約100件の投稿と約5000件の閲覧を得た｡
なお､本総括班員による研究発表については､各自担当の計画研究課題の報告書に詳述する｡

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

公募研究班員を迎えた発足２年目の位置づけに鑑みて、二度の総括班会議と一度の班会議を基盤に、三度の国際シンポジウム開催（共催含む）と三度の海外研究リーダーによるセミナーを開催し、班員間の視点共有と共同研究促進のみならず、本領域研究を国際的科学者コミュニティにアピールするとともに、新たな研究連携を図る活動を行った。このうち、第１回国際シンポジウムに海外１７カ国からの１０２名を含む２９４名と多数の参加者を得たことは、当初計画を上回る成果といえる。
また、次世代研究者の育成に資するべく、合宿形式でのサマースクールを開催した。その結果、関連研究室の大学院生を含む若手研究者４３名の参加があり、事後アンケートではプログラム・ロケーション・運営・目的を含め、総合的にたいへん良好な評価を得るとともに、次年度からもサマースクールを開催することが強く支持された。この高評価も、当初計画を上回る成果といえる。
さらに国民との対話活動について、日本免疫学会の科学コミュニケーション活動「免疫ふしぎ未来２０１３（日本科学未来館にて８月に開催）」に参加し、パネル展示やショートトークを通じて極めて多くの国民（来場者２２８７名）と双方向の対話をすることができた。本研究班による研究成果３件（骨髄ニッチFoxc1の同定､３Dバイオプリンターでの臓器作製､アルツハイマー病原因物質の同定）に関して、全国紙とニュース番組でそれぞれ多数の報道を頂いた。また、本領域のウェブサイトと班員ブログはそれぞれ、年間１２０００回以上と約５０００件の閲覧があった。これらのように、たいへん多くの国民を対象に科学コミュニケーション活動を実施することができたことは、当初計画を上回る成果といえる。

Strategy for Future Research Activity

平成２６年度においても、研究方針を企画・調整するとともに、必要な関連技術や実験材料を共有できるように研究支援し、班全体の活動について助言と評価を行う。また、研究班３年目としての中間評価が予定されているので、総括班として備える。具体的な活動としては、研究領域の国際的先導性を確保し次世代研究者の育成を促進する目的で、公募班員を含む班員間の情報共有に必要な班会議、次世代研究者の育成を対象としたサマースクールを開催する。また、周辺学術領域への研究展開と情報交換を目的として、６月に新学術領域「配偶子産生制御」研究班との二班合同ワークショップを開催するとともに、１２月に日本免疫学会学術集会における国際シンポジウム「Microenvironments for stem and immune cells」を共催する。これら会議の企画運営、オンラインニュースレター、ブログの活用を通して公募班員を含む班員間の情報交換、視点共有と科学者コミュニティとの連携を強化するとともに、総括班連携研究者および計画研究者は多様な学問背景を生かし、必要に応じて研究技術講習会等を開催する。更に、ウェブサイト、ブログ、日本免疫学会の進める科学コミュニケーション活動「免疫ふしぎ未来」への参加などによる国民との対話活動を通じて、研究領域の社会への定着と次世代研究者の育成を図る。

Research Products

• [Journal Article] Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. (2014)
  • Author(s): Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song SY, Hoshino T, Yagita H, Ohteki T, Iwata M.
  • Journal Title: Mucosal Immunol. Volume: 7 Pages: 786-801
  • DOI: 10.1038/mi.2013.96
  • Peer Reviewed
• [Journal Article] CD28-CD80/86 and CD40-CD40L costimulatory pathways cooperate for development of thymic medullary epithelium and thymocyte self tolerance. (2014)
  • Author(s): Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
  • Journal Title: J Immunol. Volume: 192 Pages: 630-640
  • DOI: 10.4049/jimmunol.1302550
  • Peer Reviewed
• [Journal Article] Retinoic Acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells. (2014)
  • Author(s): Ohoka Y, Yokota-Nakatsuma A, Maeda N, Takeuchi H, Iwata M.
  • Journal Title: PLoS One. Volume: 9 Pages: e96512
  • DOI: 10.1371/journal.pone.0096512
  • Peer Reviewed
• [Journal Article] Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody. (2014)
  • Author(s): Shiheido H, Chen C, Hikida M, Watanabe T, Shimizu J.
  • Journal Title: PLoS One. Volume: 9 Pages: e94324
  • DOI: 10.1371/journal.pone.0094324
  • Peer Reviewed
• [Journal Article] Meis1 is required for the maintenance of postnatal thymic epithelial cells. (2014)
  • Author(s): Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R.
  • Journal Title: PLoS One. Volume: 9 Pages: e89885
  • DOI: 10.1371/journal.pone.0089885
  • Peer Reviewed
• [Journal Article] Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation (2014)
  • Author(s): Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T.
  • Journal Title: Nature Volume: 508 Pages: 536-540
  • DOI: 10.1038/nature13071
  • Peer Reviewed
• [Journal Article] Elephant shark genome provides unique insights into gnathostome evolution. (2014)
  • Author(s): Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho S, Lorente-Galdos B, Quilez J, Marques-Bonet T, Raney BJ, Ingham PW, Tay A
  • Journal Title: Nature Volume: 505 Pages: 174-179
  • DOI: 10.1038/nature12826.
  • Peer Reviewed
• [Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. (2014)
  • Author(s): Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H.
  • Journal Title: Nat Med Volume: 20 Pages: 62-68
  • DOI: 10.1038/nm.3432.
  • Peer Reviewed
• [Journal Article] Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation (2014)
  • Author(s): Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Fuchtbauer E-M, Fuchtbauer A, Holtzman DM, Takagi J, Wilnow TE.
  • Journal Title: Sci Transl Med Volume: 6 Pages: 223ra20
  • DOI: 10.1126/scitranslmed.3007747
  • Peer Reviewed
• [Journal Article] Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo. (2014)
  • Author(s): Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K.
  • Journal Title: Proc Natl Acad Sci USA Volume: 111 Pages: 1915-1920
  • DOI: 10.1073/pnas.1318281111.
  • Peer Reviewed
• [Journal Article] NKG2D triggers cytotoxicity in murine epidermal γδ T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway. (2014)
  • Author(s): Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T.
  • Journal Title: J Invest Dermatol Volume: 134 Pages: 396-404
  • DOI: 10.1038/jid.2013.353.
  • Peer Reviewed
• [Journal Article] A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP (2014)
  • Author(s): Hizukuri Y, Oda T, Tabata S, Tamura-Kawakami K, Oi R, Sato M, Takagi J, Akiyama Y, Nogi T.
  • Journal Title: Structure Volume: 22 Pages: 326-336
  • DOI: 10.1016/j.str.2013.12.003
  • Peer Reviewed
• [Journal Article] Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus). (2014)
  • Author(s): Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Suzuki R, Inoko H, Walter L, Shiina T.
  • Journal Title: J Immunol Volume: 192 Pages: 3239-3246
  • DOI: 0.4049/jimmunol.1302745.
  • Peer Reviewed
• [Journal Article] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation (2014)
  • Author(s): Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J.
  • Journal Title: Eur J Immunol Volume: in press Pages: in press
  • DOI: 10.1002/eji.201344146
  • Peer Reviewed
• [Journal Article] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse (2014)
  • Author(s): Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
  • Journal Title: Eur J Immunol Volume: 44 Pages: 561-572
  • DOI: 10.1002/eji.201343750
  • Peer Reviewed
• [Journal Article] A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. (2014)
  • Author(s): Moutai T, Yamana H, Nojima T, Kitamura D.
  • Journal Title: PLoS One Volume: 9 Pages: e92732
  • DOI: 10.1371/journal.pone.0092732.
  • Peer Reviewed
• [Journal Article] Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine (2014)
  • Author(s): Nagatake T, Fujita H, Minato N, Hamazaki Y.
  • Journal Title: PLoS One Volume: 9 Pages: e90638
  • DOI: 10.1371/journal.pone.0090638
  • Peer Reviewed
• [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development. (2014)
  • Author(s): Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
  • Journal Title: PLoS One Volume: 9 Pages: e89115
  • DOI: 10.1371/journal.pone.0089115.
  • Peer Reviewed
• [Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis. (2014)
  • Author(s): Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
  • Journal Title: PLoS One Volume: 9 Pages: e87646
  • DOI: 10.1371/journal.pone.0087646.
  • Peer Reviewed
• [Journal Article] Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module. (2014)
  • Author(s): Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M, Ose T.
  • Journal Title: PLoS One Volume: 9 Pages: e85875
  • DOI: 10.1371/journal.pone.0085875.
  • Peer Reviewed
• [Journal Article] Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia (2014)
  • Author(s): Matsui N, Ohigashi I, Tanaka K, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
  • Journal Title: J Neuroimmunol Volume: 269 Pages: 56-61
  • DOI: 10.1016/j.jneuroim.2014.01.011
  • Peer Reviewed
• [Journal Article] Corticomedullary differentiation and maturational arrest in thymomas. (2014)
  • Author(s): Storbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Schalke B, Kasahara M, Tomaru U, Marx A.
  • Journal Title: Histopathology Volume: 64 Pages: 557-566
  • DOI: 10.1111/his.12279.
  • Peer Reviewed
• [Journal Article] Expression of thymoproteasome subunit β5t in type AB thymoma. (2014)
  • Author(s): Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y.
  • Journal Title: J Clin Pathol Volume: 67 Pages: 276-278
  • DOI: 10.1111/his.12279.
  • Peer Reviewed
• [Journal Article] PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin (2014)
  • Author(s): Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
  • Journal Title: Protein Expr Purif Volume: 95 Pages: 240-247
  • DOI: 10.1016/j.pep.2014.01.009
  • Peer Reviewed
• [Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8. (2014)
  • Author(s): Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
  • Journal Title: Immunity, Inflammation and Diseases Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance (2013)
  • Author(s): Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC.
  • Journal Title: Nature Volume: 495 Pages: 227-230
  • DOI: 10.1038/nature11926
  • Peer Reviewed
• [Journal Article] Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection (2013)
  • Author(s): Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG.
  • Journal Title: Immunity Volume: 39 Pages: 912-924
  • DOI: 10.1016/j.immuni.2013.08.038
  • Peer Reviewed
• [Journal Article] The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway (2013)
  • Author(s): Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H.
  • Journal Title: Dev Cell Volume: 26 Pages: 292-302
  • DOI: 10.1016/j.devcel.2013.06.008
  • Peer Reviewed
• [Journal Article] Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin (2013)
  • Author(s): Li W, Kohara H, Uchida Y, James JM, Soneji K, Cronshaw DG, Zou YR, Nagasawa T, Mukouyama YS.
  • Journal Title: Dev Cell Volume: 24 Pages: 359-371
  • DOI: 10.1016/j.devcel.2013.01.009
  • Peer Reviewed
• [Journal Article] Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse (2013)
  • Author(s): Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonner G, Fukui Y, Huse M.
  • Journal Title: J Exp Med Volume: 210 Pages: 2721-2737
  • DOI: 10.1084/jem.20131324
  • Peer Reviewed
• [Journal Article] Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow (2013)
  • Author(s): Devi S, Wang Y, Chew WK, Lima R, A-Gonzalez N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S,
  • Journal Title: J Exp Med Volume: 210 Pages: 2321-2336
  • DOI: 10.1084/jem.20130056
  • Peer Reviewed
• [Journal Article] Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. (2013)
  • Author(s): Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D,
  • Journal Title: J Clin Invest Volume: 123 Pages: 5009-5022
  • DOI: 10.1172/JCI70626.
  • Peer Reviewed
• [Journal Article] Histamine receptor 2 modifies dendritic cell responses to microbial ligands (2013)
  • Author(s): Frei F, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles TM, Mailand S, Watanabe T, Lauener R, Akdis C, O’Mahony L.
  • Journal Title: J Allergy Clin Immunol Volume: 132 Pages: 194-204e12
  • DOI: 10.1016/j.jaci.2013.01.013
  • Peer Reviewed
• [Journal Article] The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation (2013)
  • Author(s): Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi A, Sanematsu F, Fukui Y.
  • Journal Title: Blood Volume: 122 Pages: 386-393
  • DOI: 10.1182/blood-2012-12-475897
  • Peer Reviewed
• [Journal Article] TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development (2013)
  • Author(s): Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 21107-21112
  • DOI: 10.1073/pnas.1314859111
  • Peer Reviewed
• [Journal Article] GATA-1 regulates the generation and function of basophils (2013)
  • Author(s): Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 18620-18625
  • DOI: 10.1073/pnas.1311668110
  • Peer Reviewed
• [Journal Article] Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis (2013)
  • Author(s): Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe-Kains B, Muller WJ, Cote JF.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 7434-7439
  • DOI: 10.1073/pnas.1213050110
  • Peer Reviewed
• [Journal Article] The interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. (2013)
  • Author(s): Tani-ichi S, Shimba A, Wagatsuma K, Miyachi H, Kitano S, Imai K, Hara T, and Ikuta, K.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 110 Pages: 612-617
  • DOI: 10.1073/pnas.1219242110.
  • Peer Reviewed
• [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells (2013)
  • Author(s): Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Hollander GA, Takahama Y.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 9885-9890
  • DOI: 10.1073/pnas.1301799110
  • Peer Reviewed
• [Journal Article] HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression. (2013)
  • Author(s): Yamamoto-Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K, Kinashi T, Matsuoka M.
  • Journal Title: PLoS Pathog Volume: 9 Pages: e1003630
  • DOI: 10.1371/journal.ppat.1003630.
  • Peer Reviewed
• [Journal Article] A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo (2013)
  • Author(s): Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y,
  • Journal Title: Sci Transl Med Volume: 5 Pages: 181ra52
  • DOI: 10.1126/scitranslmed.3004387
  • Peer Reviewed
• [Journal Article] B cell progenitors and precursors change their microenvironment in fetal liver during early development. (2013)
  • Author(s): Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, Melchers F.
  • Journal Title: Stem Cells Volume: 31 Pages: 2800-2812
  • DOI: 10.1002/stem.1421.
  • Peer Reviewed
• [Journal Article] A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium (2013)
  • Author(s): Kobayashi S, Miura K, Shibuya H, Morita M, Ishikawa M, Furu M, Ito H, Matsuda S, Watanabe T, Yoshitomi H.
  • Journal Title: Arthritis Rheum Volume: 65 Pages: 3063-3072
  • DOI: 10.1002/art.38173
  • Peer Reviewed
• [Journal Article] Necessity of lysophosphatidic acid receptor 1 for development of arthritis (2013)
  • Author(s): Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.
  • Journal Title: Arthritis Rheum Volume: 65 Pages: 2037-2047
  • DOI: 10.1002/art.37991
  • Peer Reviewed
• [Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration (2013)
  • Author(s): Nojima S, Toyofuku T, Kamao H, Ishigami C, Kaneko J, Okuno T, Takamatsu H, Ito D, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Ogata A, Ikawa M, Morii E, Aozasa K, Takagi J, Takahashi M, Kumanogoh A.
  • Journal Title: Nat Commun Volume: 4 Pages: 1406
  • DOI: 10.1038/ncomms2420
  • Peer Reviewed
• [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens (2013)
  • Author(s): Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh, A, Nomura T, Hanakawa S, Moniaga C, Kim, B, Matsuoka S, Watanabe T, Miyachi Y, Kabashima K.
  • Journal Title: Nat Commun Volume: 4 Pages: 1738
  • DOI: 10.1038/ncomms2740
  • Peer Reviewed
• [Journal Article] Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling (2013)
  • Author(s): Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield M, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S.
  • Journal Title: Cardiovasc Res Volume: 99 Pages: 705-715
  • DOI: 10.1093/cvr/cvt146
  • Peer Reviewed
• [Journal Article] Retinoid X Receptor Agonists Modulate Foxp3+ Regulatory T Cell and Th17 Cell Differentiation with Differential Dependence on Retinoic Acid Receptor Activation. (2013)
  • Author(s): Takeuchi H, Yokota-Nakatsuma A, Ohoka Y, Kagechika H, Kato C, Song SY, Iwata M.
  • Journal Title: J Immunol Volume: 91 Pages: 3725-3733
  • DOI: 10.4049/jimmunol.1300032.
  • Peer Reviewed
• [Journal Article] Human CD1c+ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D3. (2013)
  • Author(s): Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, Ohteki T, Hasegawa S, Kawada K, Sakai Y, Ikeuchi H, Nakase H, Niwa A, Takaori-Kondo A, Kadowaki N.
  • Journal Title: J Immunol Volume: 191 Pages: 3152-3160
  • DOI: 10.4049/jimmunol.1203517.
  • Peer Reviewed
• [Journal Article] Dendritic cells regulate high-speed interstitial T cell migration in the lymph node via LFA-1/ ICAM-1. (2013)
  • Author(s): Katakai T, Habiro K, Kinashi T.
  • Journal Title: J Immunol. Volume: 191 Pages: 1188-1199
  • DOI: 10.4049/jimmunol.1300739.
  • Peer Reviewed
• [Journal Article] Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. (2013)
  • Author(s): Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K.
  • Journal Title: J Immunol Volume: 190 Pages: 6173-6179
  • DOI: 10.4049/jimmunol.1202573.
  • Peer Reviewed
• [Journal Article] Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells. (2013)
  • Author(s): Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.
  • Journal Title: J Immunol Volume: 190 Pages: 5110-5117
  • DOI: 10.4049/jimmunol.1203203
  • Peer Reviewed
• [Journal Article] Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis (2013)
  • Author(s): *Bai Z, *Cai L, *Umemoto E, *Takeda A, Tohya K,Komai Y, Veeraveedu PT, Hata E, Sugiura Y, Kubo A, Suematsu M, Hayasaka H, Okudaira S, Aoki J, Tanaka T, Albers HMHG, Ovaa H, Miyasaka M. (*equal contribution)
  • Journal Title: J Immunol Volume: 190 Pages: 2036-2048
  • DOI: 10.4049/jimmunol.1202025
  • Peer Reviewed
• [Journal Article] Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. (2013)
  • Author(s): Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD.
  • Journal Title: J Immunol Volume: 190 Pages: 970-976
  • DOI: 10.4049/jimmunol.1202805.
  • Peer Reviewed
• [Journal Article] Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques. (2013)
  • Author(s): Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M.
  • Journal Title: J Immunol Volume: 190 Pages: 605-612
  • DOI: 10.4049/jimmunol.1201345.
  • Peer Reviewed
• [Journal Article] Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation (2013)
  • Author(s): Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Cote JF, Fukui Y.
  • Journal Title: J Biol Chem Volume: 288 Pages: 8092-8100
  • DOI: 10.1074/jbc.M112.410423
  • Peer Reviewed
• [Journal Article] Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6) (2013)
  • Author(s): Unoki M, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, Fukui Y, Ueda K, Hamamoto R, Shirakawa M, Sasaki H, Nakamura Y.
  • Journal Title: J Biol Chem Volume: 288 Pages: 6053-6062
  • DOI: 10.1074/jbc.M112.433284
  • Peer Reviewed
• [Journal Article] Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. (2013)
  • Author(s): Umemoto E, Takeda A, Jin S, Luo Z, Nakahogi N, Hayasaka H, Lee CM, Tanaka T, Miyasaka M.
  • Journal Title: PLOS One Volume: 8 Pages: e83681
  • DOI: 10.1371/journal.pone.0083681.
  • Peer Reviewed
• [Journal Article] Moesin controls clathrin-mediated S1PR1 internalization in T cells (2013)
  • Author(s): Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Toyama K, Thumkeo D, Watanabe T, Narumiya S, Hirata T.
  • Journal Title: PLoS One Volume: 8 Pages: e82590
  • DOI: 10.1371/journal.pone.0082590
  • Peer Reviewed
• [Journal Article] DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis. (2013)
  • Author(s): Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S, Kitamura D.
  • Journal Title: PLOS One Volume: 8 Pages: e80223
  • DOI: 10.1371/journal.pone.0080223.
  • Peer Reviewed
• [Journal Article] Contrasting quiescent G0 phase with mitotic cell cycling in the mouse immune system. (2013)
  • Author(s): Tomura M, Sawano AS, Mori Y, Takase M, Hata A, Ohtawa K, Kanagawa O, Miyawaki A.
  • Journal Title: PLOS One Volume: 8 Pages: e73801
  • DOI: 10.1371/journal.pone.0073801.
  • Peer Reviewed
• [Journal Article] Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase. (2013)
  • Author(s): Tomiyama T, Ueda Y, Katakai T, Kondo N, Okazaki K, Kinashi T.
  • Journal Title: PLoS One Volume: 8 Pages: e73874
  • DOI: 10.1371/journal.pone.0073874.
  • Peer Reviewed
• [Journal Article] Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus. (2013)
  • Author(s): Bryson JL, Griffith AV, Hughes Iii B, Saito F, Takahama Y, Richie ER, Manley NR.
  • Journal Title: PLoS One Volume: 8 Pages: e65196
  • DOI: 10.1371/journal.pone.0065196.
  • Peer Reviewed
• [Journal Article] CD49b-dependent establishment of T helper cell memory. (2013)
  • Author(s): Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Lohning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T.
  • Journal Title: Immunol Cell Biol Volume: 91 Pages: 524-531
  • DOI: 10.1038/icb.2013.36.
  • Peer Reviewed
• [Journal Article] Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo. (2013)
  • Author(s): Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J.
  • Journal Title: Dev Biol Volume: 380 Pages: 172-184
  • DOI: 10.1016/j.ydbio.2013.05.020.
  • Peer Reviewed
• [Journal Article] Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes. (2013)
  • Author(s): Lee JK, Won C, Yi EH, Seok SH, Kim MH, Kim SJ, Chung MH, Lee HG, Ikuta K, Ye SK.
  • Journal Title: Immunology Volume: 140 Pages: 288-300
  • DOI: 10.1111/imm.12133.
  • Peer Reviewed
• [Journal Article] Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods (2013)
  • Author(s): Watanabe TM, Fujii F, Jin T, Umemoto E, Miyasaka M, Fujita H, Yanagida T.
  • Journal Title: Biophys J Volume: 105 Pages: 555-564
  • DOI: 10.1016/j.bpj.2013.07.001
  • Peer Reviewed
• [Journal Article] Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery (2013)
  • Author(s): Kurobe H, Tominaga T, Sugano M, Hayabuchi Y, Egawa Y, Takahama Y, Kitagawa T.
  • Journal Title: J Thorac Cardiovasc Surg Volume: 145 Pages: 656-662
  • DOI: 10.1016/j.jtcvs.2012.12.015
  • Peer Reviewed
• [Journal Article] Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid (2013)
  • Author(s): Idrees AM, Sugie T, Inoue C, Murata-Hirai K, Okamura H, Morita CT. Minato N, Toi M, Tanaka Y.
  • Journal Title: Cancer Sci Volume: 104 Pages: 536-542
  • DOI: 10.1111/cas.12124
  • Peer Reviewed
• [Journal Article] Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors. (2013)
  • Author(s): Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, Ikuta K.
  • Journal Title: Mol Immunol Volume: 54 Pages: 378-385
  • DOI: 10.1016/j.molimm.2013.01.002.
  • Peer Reviewed
• [Journal Article] A multipurpose fusion tag derived from an unstructured and hyperacidic region of the amyloid precursor protein (2013)
  • Author(s): Sangawa T, Tabata S, Suzuki K, Saheki Y, Tanaka K, and Takagi J.
  • Journal Title: Protein Sci Volume: 22 Pages: 840-850
  • DOI: 10.1002/pro.2254
  • Peer Reviewed
• [Journal Article] Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease (2013)
  • Author(s): Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD.
  • Journal Title: Exp Mol Pathol Volume: 94 Pages: 366-371
  • DOI: 10.1016/j.yexmp.2013.01.002
  • Peer Reviewed
• [Journal Article] Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development (2013)
  • Author(s): Hisano Y, Ota S, Takada S, Kawahara A.
  • Journal Title: Biol Open Volume: 2 Pages: 789-794
  • DOI: 10.1242/bio.20134994
  • Peer Reviewed
• [Remarks] 免疫四次元空間ダイナミクス
  • URL: http://www.genome.tokushima-u.ac.jp/ion/index.html