免疫四次元空間ダイナミクス

2014 Fiscal Year Annual Research Report

• Project Area: Analysis and synthesis of multi-dimensional immune organ network
• Project/Area Number: 24111001
• Research Institution: The University of Tokushima
• Principal Investigator: 高濱 洋介 徳島大学, 疾患プロテオゲノム研究センター, 教授 (20183858)
• Co-Investigator(Kenkyū-buntansha): 渡邊 武 公益財団法人田附興風会, 医学研究所, 特任研究指導者 (40028684) ; 湊 長博 京都大学, 医学(系)研究科(研究院), 教授 (40137716) ; 宮坂 昌之 大阪大学, その他部局等, 名誉教授 (50064613) ; 高田 慎治 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), その他部局等, 教授 (60206753) ; 福井 宣規 九州大学, 生体防御医学研究所, 教授 (60243961) ; 長澤 丘司 京都大学, 再生医科学研究所, 教授 (80281690) ; 高木 淳一 大阪大学, たんぱく質研究所, 教授 (90212000)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 免疫学 / ストローマ細胞 / 免疫の場 / リンパ器官 / 免疫空間

Outline of Annual Research Achievements

本総括班は、活発かつ効率的に研究が進むよう視点共有を図り、研究方針を企画調整するとともに、技術や材料の共有を支援し、助言と評価を行う。また、班員間と科学者コミュニティとの連携を促進し、研究領域の社会への定着と次世代研究者の育成を図る。この目的で今年度は、班員間の情報共有と共同研究を促進すべく班会議を開催し、次世代研究者育成を促進すべく班員の研究室に所属する若手研究者を主対象とする研修会を開催した。また、周辺学術領域への研究展開と情報交換のため、６月に新学術領域「配偶子産生制御」班との二班合同ワークショップを開催し、５月に日本発生生物学会大会の国際シンポジウム（約１５０名参加）、１２月に日本免疫学会学術集会の国際シンポジウム（約３００名参加）を共催した。更に、九州大学および徳島大学における国際シンポジウムを共催し（各約１００名参加）、海外研究者セミナーを徳島大学にて二度開催した。国民との対話については、日本免疫学会の科学コミュニケーション活動「免疫ふしぎ未来２０１４」に参加し、パネル展示とショートトークにて多数の国民と双方向対話を行い（来場者２４３７名）、ＮＨＫスペシャル「人体 ミクロの大冒険」の制作に協力し、胸腺上皮幹細胞の研究、アレルギー疾患におけるDOCK5に関する研究、アミロイドベータ結合sorLAの構造研究、3D Printerを用いた再生医療の研究に関して全国紙とニュース番組で多数報道頂いた。科学者コミュニティと一般社会に向けたウェブサイトでは本年度、ニュース掲載６０件と１３８９０回の閲覧、班員の視点共有促進のための班員ブログでは本年度８３件の投稿と約８０００件の閲覧を得た。また、オンラインニュースレターを二度発行した。これらの活動を基盤に総括班会議を二度開催し、学術調査官による助言を得、研究班３年目の中間評価に臨みＡ評価を得た。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

五年間の研究班運営の中間にあたる発足三年目の位置づけに鑑みて、二度の総括班会議と一度の班会議を基盤に、四度の国際シンポジウム共催と二度の海外研究者セミナーを開催し、班員間の視点共有と共同研究促進、国内外の科学者コミュニティへの本領域研究のアピール、新たな研究の連携を図った。なかでも、新学術領域「動物における配偶子産生システム制御」と「ニッチの謎を議論する」 と題する二班合同ワークショップを開催した。特定の細胞の分化や機能を支持し制御する場「ニッチ」という共通の興味に向き合い議論することで思考を深め従来なかった気づきを得、二つの新学術領域研究が互いに意識してより新しい学術領域の創成と定着を指向する新しい試みであり、当初計画を上回る成果といえる。
また、次世代研究者の育成に資するべく、合宿形式での若手研修会（サマースクール）を開催した。関連研究室の大学院生を主に３５名の参加があり、事後アンケートでは総合的に極めて良好な評価を得、次年度開催も強く支持された。次世代研究者からの高評価は、当初計画を上回る成果といえる。
さらに国民との対話活動について、日本免疫学会の科学コミュニケーション活動「免疫ふしぎ未来２０１４（日本科学未来館にて８月開催）」に参加し、パネル展示とショートトークを通じて多数の国民（来場者２４３７名）と双方向の対話を行うとともに、本研究班による研究成果４件に関して全国紙とニュース番組で多数の報道を頂いた。また、ＮＨＫスペシャル「人体 ミクロの大冒険」の制作に協力し、本領域のウェブサイトと班員ブログはそれぞれ、年間１３０００回以上と約８０００件の閲覧を得た。多くの国民を対象に科学コミュニケーション活動を実施できたことは、当初計画を上回る成果といえる。
研究班３年目の中間評価においてＡ評価を得たことも、当初の計画以上に進展していると判断した理由である。

Strategy for Future Research Activity

平成２７年度においても、研究方針を企画・調整するとともに、必要な関連技術や実験材料を共有できるように研究支援し、班全体の活動について助言と評価を行う。また、研究班４年目として新たな公募研究者の受け入れが予定されているので、総括班として備える。具体的な活動としては、研究領域の国際的先導性を確保し次世代研究者の育成を促進する目的で、公募班員を含む班員間の情報共有に必要な班会議、次世代研究者の育成を対象とするサマースクールを開催する。また、班員に対する研究支援をこれまで以上に充実させるべく、新たに他機関で研究室をスタートアップする班員を主な対象に、班研究に有効活用される実験動物などの研究資材の移動に必要な経費などを支援する「プロモーション支援事業」を始動させた。その他、主催または共催の研究集会の企画運営、オンラインニュースレター、ブログの活用を通して公募班員を含む班員間の情報交換、視点共有と科学者コミュニティとの連携を強化するとともに、総括班連携研究者および計画研究者は多様な学問背景を生かし、研究技術講習会等を積極的に開催する。更に、ウェブサイト、ブログ、日本免疫学会の進める科学コミュニケーション活動「免疫ふしぎ未来」への参加などによる国民との対話活動を通じて、「免疫四次元空間ダイナミクス」新学術研究領域の社会への定着と次世代研究者の育成を図る。

Research Products

• [Journal Article] The endothelial protein Plvap in lymphatics controls lymphocyte and antigen entry to lymph nodes. (2015)
  • Author(s): Rantakari P, Auvinen K, Jappinen N, Kapraali M, Valtonen J, Karikoski M, Gerke H, Iftakhar-E-Khuda I, Keuschnigg J, Umemoto E, Tohya K, Miyasaka M, Elima K, Jalkanen S, Salmi M.
  • Journal Title: Nat Immunol. Volume: 16 Pages: 386-396
  • DOI: 10.1038/nature13071
  • Peer Reviewed
• [Journal Article] Structural basis for amyloidogenic peptide recognition by sorLA. (2015)
  • Author(s): Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J.
  • Journal Title: Nat Struct Mol Biol. Volume: 22 Pages: 199-206
  • DOI: 10.1038/nsmb.2954
  • Peer Reviewed
• [Journal Article] Real-time tracking of cell cycle progression during CD8(+) effector and memory T-cell differentiation. (2015)
  • Author(s): Kinjyo I, Qin J, Tan SY, Wellard CJ, Mrass P, Ritchie W, Doi A, Cavanagh LL, Tomura M, Sakaue-Sawano A, Kanagawa O, Miyawaki A, Hodgkin PD, Weninger W.
  • Journal Title: Nat Commun. Volume: 6 Pages: 6301
  • DOI: 10.1038/ncomms7301
  • Peer Reviewed
• [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells. (2015)
  • Author(s): Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
  • Journal Title: EMBO Rep. Volume: なし Pages: e201540096
  • DOI: 10.15252/embr.201540096
  • Peer Reviewed
• [Journal Article] IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production (2015)
  • Author(s): Jung Y, Wen T, Mingler MK, Wang YH, Chaplin DD, Lee EH, Jang MH, Woo SY, Seoh JY, Miyasaka M, Rothenberg ME.
  • Journal Title: Mucosal Immunol. Volume: なし Pages: 印刷中
  • DOI: 10.1038/mi.2014.123
  • Peer Reviewed
• [Journal Article] JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. (2015)
  • Author(s): Kitabatake M, Soma M, Zhang T, Kuwahara K, Fukushima Y, Nojima T, Kitamura D, Sakaguchi N.
  • Journal Title: J Immunol. Volume: 194 Pages: 1480-1488
  • DOI: 10.4049/jimmunol.1401127
  • Peer Reviewed
• [Journal Article] A genome-wide analysis identifies a Notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. (2015)
  • Author(s): Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y.
  • Journal Title: J Immunol. Volume: 194 Pages: 243-251
  • DOI: 10.4049/jimmunol.1401619
  • Peer Reviewed
• [Journal Article] Egress of Mature Murine Regulatory T Cells from the Thymus Requires RelA. (2015)
  • Author(s): Fukazawa T, Hiraiwa N, Umemura T, Mise-Omata S, Obata Y, Doi T.
  • Journal Title: J Immunol. Volume: 194 Pages: 3020-3028
  • DOI: 10.4049/jimmunol.1302756
  • Peer Reviewed
• [Journal Article] Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia. (2015)
  • Author(s): Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.
  • Journal Title: Sci Rep. Volume: 5 Pages: 7978
  • DOI: 10.1038/srep07978
  • Peer Reviewed
• [Journal Article] Axl phosphorylates Elmo scraffold proteins to promote Rac activation and cell invasion. (2015)
  • Author(s): Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Cote JF.
  • Journal Title: Mol Cell Biol. Volume: 35 Pages: 76-87
  • DOI: 10.1128/MCB.00764-14
  • Peer Reviewed
• [Journal Article] Anchorage-dependent multicellular aggregate formation induces CD44 high cancer stem cell-like ATL cells in an NF-κB- and vimentin-dependent manner. (2015)
  • Author(s): Miyatake Y, Sheehy N, Ikeshita S, Hall WW, Kasahara M.
  • Journal Title: Cancer Lett. Volume: 357 Pages: 355-363
  • DOI: 10.1016/j.canlet.2014.11.055
  • Peer Reviewed
• [Journal Article] The SKINT1-like gene is inactivated in hominoids but not in all primate species: implications for the origin of epidermal dendritic T cells. (2015)
  • Author(s): Mohamed R H, Sutoh Y, Itoh Y, Miyatake Y, Otsuka N, Ogasawara K, Kasahara M.
  • Journal Title: PLoS ONE. Volume: 10 Pages: e0123258
  • DOI: 10.1371/journal.pone.0123258
  • Peer Reviewed
• [Journal Article] The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7. (2015)
  • Author(s): Hayasaka H, Kobayashi D, Yoshimura H, Nakayama EE, Shioda T, Miyasaka M.
  • Journal Title: PLoS ONE. Volume: 10 Pages: e0117454
  • DOI: 10.1371/journal.pone.0117454
  • Peer Reviewed
• [Journal Article] New immunosuppressive strategies for transplantation based on pluripotent stem cell (PSC)-derived immunoregulatory cells. (2015)
  • Author(s): Seino K, Wada H, Baghdadi M.
  • Journal Title: Stem Cell Transl Invest Volume: 2 Pages: e504
  • DOI: 10.14800/scti.504
  • Peer Reviewed
• [Journal Article] Decreased expression of thymus-specific proteasome subunit β5t in Down syndrome patients. (2015)
  • Author(s): Tomaru U, Tsuji T, Kiuchi S, Ishizu A, Suzuki A, Otsuka N, Ito T, Ikeda H, Fukasawa Y, Kasahara M.
  • Journal Title: Histopathology. Volume: なし Pages: 印刷中
  • DOI: 10.1111/his.12642
  • Peer Reviewed
• [Journal Article] Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis. (2015)
  • Author(s): Iinuma C, Waki M, Kawakami A, Yamaguchi M, Tomaru U, Sasaki N, Masuda S, Matsui Y, Iwasaki S, Baba T, Kasahara M, Yoshiki T, Paletta D, Herrmann T, Ishizu A.
  • Journal Title: Int Immunol. Volume: 27 Pages: 105-114
  • DOI: 10.1093/intimm/dxu088
  • Peer Reviewed
• [Journal Article] Pancreatic cancer cells express CD44 variant 9 and multidrug resistance protein 1 during mitosis. (2015)
  • Author(s): Kiuchi S, Ikeshita S, Miyatake Y, Kasahara M.
  • Journal Title: Exp Mol Pathol. Volume: 98 Pages: 41-46
  • DOI: 10.1016/j.yexmp.2014.12.001
  • Peer Reviewed
• [Journal Article] Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms. (2015)
  • Author(s): Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y.
  • Journal Title: J Histochem Cytochem. Volume: 63 Pages: 217-227
  • DOI: 10.1369/0022155414563800
  • Peer Reviewed
• [Journal Article] Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFN-γ-dependent cell cycle arrest. (2015)
  • Author(s): Matsushita H, Hosoi A, Ueha S, Abe J, Fujieda N, Tomura M, Maekawa R, Matsushima K, Ohara O, Kakimi K.
  • Journal Title: Cancer Immunol Res. Volume: 3 Pages: 26-36
  • DOI: 10.1158/2326-6066.CIR-14-0098
  • Peer Reviewed
• [Journal Article] Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation. (2014)
  • Author(s): Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T.
  • Journal Title: Nature. Volume: 508 Pages: 536-540
  • DOI: 10.1038/nature13071
  • Peer Reviewed
• [Journal Article] Elephant shark genome provides unique insights into gnathostome evolution. (2014)
  • Author(s): Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho Sら
  • Journal Title: Nature. Volume: 505 Pages: 174-179
  • DOI: 10.1038/nature12826
  • Peer Reviewed
• [Journal Article] Neutrophils scan for activated platelets to initiate inflammation. (2014)
  • Author(s): Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi M-D, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A.
  • Journal Title: Science Volume: 346 Pages: 1234-1238
  • DOI: 10.1126/science.1256478
  • Peer Reviewed
• [Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis (2014)
  • Author(s): Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H.
  • Journal Title: Nat Med. Volume: 20 Pages: 62-68
  • DOI: 10.1038/nm.3432
  • Peer Reviewed
• [Journal Article] Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance. (2014)
  • Author(s): Sekai M, Hamazaki Y, Minato N.
  • Journal Title: Immunity. Volume: 41 Pages: 753-761
  • DOI: 10.1016/j.immuni.2014.10.011
  • Peer Reviewed
• [Journal Article] Thromboxane A2 acts as tonic immunoregulator by preferentialdisruption of low-avidity CD4+ T cell-dendritic cell interactions. (2014)
  • Author(s): Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV.
  • Journal Title: J Exp Med. Volume: 211 Pages: 2507-2517
  • DOI: 10.1084/jem.20140137
  • Peer Reviewed
• [Journal Article] DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation (2014)
  • Author(s): Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A, Cote J-F, Fukui Y.
  • Journal Title: J Exp Med. Volume: 211 Pages: 1407-1419
  • DOI: 10.1084/jem.20131926
  • Peer Reviewed
• [Journal Article] In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. (2014)
  • Author(s): Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M.
  • Journal Title: J Exp Med. Volume: 211 Pages: 1123-1136
  • DOI: 10.1084/jem.20132112
  • Peer Reviewed
• [Journal Article] Lysosomal Sorting of Amyloid- (2014)
  • Author(s): Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Fuchtbauer E-M, Fuchtbauer A, Holtzman DM, Takagi J, Wilnow TE.
  • Journal Title: Sci Transl Med. Volume: 6 Pages: 223ra20
  • DOI: 10.1126/scitranslmed.3007747
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. (2014)
  • Author(s): Totsuka N, Kim Y-G, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A.
  • Journal Title: Nat Commun. Volume: 5 Pages: 4710
  • DOI: 10.1038/ncomms5710
  • Peer Reviewed
• [Journal Article] Generation of colonic IgA-secreting cells in the caecal patch. (2014)
  • Author(s): Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K.
  • Journal Title: Nat Commun. Volume: 5 Pages: 3704
  • DOI: 10.1038/ncomms4704
  • Peer Reviewed
• [Journal Article] Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance (2014)
  • Author(s): Wu L, Parekh V V, Hsiao J, Kitamura D, Van Kaer L.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 111 Pages: 4638-4647
  • DOI: 10.1073/pnas.1324052111
  • Peer Reviewed
• [Journal Article] Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes. (2014)
  • Author(s): Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T, Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 111 Pages: 7771-7776
  • DOI: 10.1073/pnas.1402914111
  • Peer Reviewed
• [Journal Article] Leucophores are similar to xanthophores in their specificatio and differentiation processes in medaka (2014)
  • Author(s): Kimura T, Nagao Y, Hashimoto H, Yamamoto-Shhiraishi Y, Yamamoto S, Yabe T, Takada S, Kinoshita M, Kuroiwa A, Naruse K.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 111 Pages: 7343-7348
  • DOI: 10.1073/pnas.1311254111
  • Peer Reviewed
• [Journal Article] Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo. (2014)
  • Author(s): Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 111 Pages: 1915-1920
  • DOI: 10.1073/pnas.1318281111
  • Peer Reviewed
• [Journal Article] Rab13 acts downstream of the kinase Mst1 to activate the integrin LFA-1 for lymphocyte trafficking. (2014)
  • Author(s): Nishikimi A, Ishihara S, Ozawa M, Etoh K, Fukuda M, Kinashi T, Katagiri K.
  • Journal Title: Sci Signal. Volume: 336 Pages: ra72
  • DOI: 10.1126/scisignal.2005199
  • Peer Reviewed
• [Journal Article] Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. (2014)
  • Author(s): Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song SY, Hoshino T, Yagita H, Ohteki T, Iwata M.
  • Journal Title: Mucosal Immunol. Volume: 7 Pages: 786-801
  • DOI: 10.1038/mi.2013.96
  • Peer Reviewed
• [Journal Article] DOCK2 is critical for CD8+TCR- graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells. (2014)
  • Author(s): Wen Y, Elliott MJ, Huang Y, Miller TO, Corbin DR, Hussain L-R, Ratajczak MZ, Fukui Y, Ildstad ST.
  • Journal Title: Stem Cells. Volume: 32 Pages: 2732-2743
  • DOI: 10.1002/stem.1780
  • Peer Reviewed
• [Journal Article] Dermal Vγ4+ γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8+ T-Cell Activity through TNF-α Production. (2014)
  • Author(s): Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
  • Journal Title: J Invest Dermatol. Volume: 135 Pages: 1007-1015
  • DOI: 10.1038/jid.2014.516
  • Peer Reviewed
• [Journal Article] NKG2D triggers cytotoxicity in murine epidermal γδ T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway. (2014)
  • Author(s): Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T.
  • Journal Title: J Invest Dermatol. Volume: 134 Pages: 396-404
  • DOI: 10.1038/jid.2013.353
  • Peer Reviewed
• [Journal Article] A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP. (2014)
  • Author(s): Hizukuri Y, Oda T, Tabata S, Tamura-Kawakami K, Oi R, Sato M, Takagi J, Akiyama Y, Nogi T.
  • Journal Title: Structure. Volume: 22 Pages: 326-336
  • DOI: 10.1016/j.str.2013.12.003
  • Peer Reviewed
• [Journal Article] P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. (2014)
  • Author(s): Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, Welch H, Der C, Stephens L, Hawkins P.
  • Journal Title: J Cell Sci. Volume: 127 Pages: 2589-2600
  • DOI: 10.1242/jcs.153049
  • Peer Reviewed
• [Journal Article] DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. (2014)
  • Author(s): Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y.
  • Journal Title: J Immunol. Volume: 193 Pages: 5660-5667
  • DOI: 10.4049/jimmunol.1400885
  • Peer Reviewed
• [Journal Article] Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses. (2014)
  • Author(s): Abe J, Shichino S, Ueha S, Hashimoto S, Tomura M, Inagaki Y, Stein JV, Matsushima K.
  • Journal Title: J Immunol. Volume: 193 Pages: 1636-1644
  • DOI: 10.4049/jimmunol.1302946
  • Peer Reviewed
• [Journal Article] Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. (2014)
  • Author(s): Fukao S, Haniuda K, Nojima T, Takai T, Kitamura D.
  • Journal Title: J Immunol. Volume: 193 Pages: 635-644
  • DOI: 10.4049/jimmunol.1302772
  • Peer Reviewed
• [Journal Article] Murine Spleen Tissue Regeneration from Neonatal Spleen Capsule Requires Lymphotoxine Priming of Stromal Cells. (2014)
  • Author(s): Tan J, Watanabe T.
  • Journal Title: J Immunol. Volume: 193 Pages: 1194-1203
  • DOI: 10.4049/jimmunol.1302115
  • Peer Reviewed
• [Journal Article] Autotaxin produced by stromal cells promotes LFA-1-independent and Rhp-dependent interstitial T cell motility in the lymph node paracortex. (2014)
  • Author(s): Katakai T, Kondo N, Ueda Y, Kinashi T.
  • Journal Title: J Immunol. Volume: 193 Pages: 617-626
  • DOI: 10.4049/jimmunol.1400565
  • Peer Reviewed
• [Journal Article] Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus). (2014)
  • Author(s): Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Suzuki R, Inoko H, Walter L, Shiina T.
  • Journal Title: J Immunol. Volume: 192 Pages: 3239-3246
  • DOI: 10.4049/jimmunol.1302745
  • Peer Reviewed
• [Journal Article] CD28-CD80/86 and CD40-CD40L costimulatory pathways cooperate for development of thymic medullary epithelium and thymocyte self tolerance. (2014)
  • Author(s): Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
  • Journal Title: J Immunol. Volume: 192 Pages: 630-640
  • DOI: 10.4049/jimmunol.1302550
  • Peer Reviewed
• [Journal Article] Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes. (2014)
  • Author(s): Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.
  • Journal Title: Sci Rep. Volume: 4 Pages: 6030
  • DOI: 10.1038/srep06030
  • Peer Reviewed
• [Journal Article] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation. (2014)
  • Author(s): Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J.
  • Journal Title: Eur J Immunol. Volume: 44 Pages: 1770-1780
  • DOI: 10.1002/eji.201344146
  • Peer Reviewed
• [Journal Article] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. (2014)
  • Author(s): Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
  • Journal Title: Eur J Immunol. Volume: 44 Pages: 561-572
  • DOI: 10.1002/eji.201343750
  • Peer Reviewed
• [Journal Article] Dental pulp dendritic cells migrate to regional lymph nodes. (2014)
  • Author(s): Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M.
  • Journal Title: J Dent Res. Volume: 93 Pages: 288-293
  • DOI: 10.1177/0022034513518223
  • Peer Reviewed
• [Journal Article] Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid - lysophosphatidic acid receptor 1 cascade. (2014)
  • Author(s): Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
  • Journal Title: Arthritis Res Ther. Volume: 16 Pages: 461
  • DOI: 10.1186/s13075-014-0461-9
  • Peer Reviewed
• [Journal Article] Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. (2014)
  • Author(s): Okumura K, Saito M, Aoto Y, Hachiya T, Sakakibara Y, Katsuragi Y, Hirose S, Kominami R, Goitsuka R, Nakamura T, Wakabayashi Y.
  • Journal Title: PloS One. Volume: 9 Pages: e102111
  • DOI: 10.1371/journal.pone.0102111
  • Peer Reviewed
• [Journal Article] Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival. (2014)
  • Author(s): Kudo H, Wada H, Sasaki H, Tsuji H, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K.
  • Journal Title: PLoS One. Volume: 9 Pages: e111826
  • DOI: 10.1371/journal.pone.0111826
  • Peer Reviewed
• [Journal Article] Retinoic Acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells. (2014)
  • Author(s): Ohoka Y, Yokota-Nakatsuma A, Maeda N, Takeuchi H, Iwata M.
  • Journal Title: PLoS One. Volume: 9 Pages: e96512
  • DOI: 10.1371/journal.pone.0096512
  • Peer Reviewed
• [Journal Article] Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody. (2014)
  • Author(s): Shiheido H, Chen C, Hikida M, Watanabe T, Shimizu J.
  • Journal Title: PLoS One. Volume: 9 Pages: e94324
  • DOI: 10.1371/journal.pone.0094324
  • Peer Reviewed
• [Journal Article] A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. (2014)
  • Author(s): Moutai T, Yamana H, Nojima T, Kitamura D.
  • Journal Title: PLoS One. Volume: 9 Pages: e92732
  • DOI: 10.1371/journal.pone.0092732
  • Peer Reviewed
• [Journal Article] Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine. (2014)
  • Author(s): Nagatake T, Fujita H, Minato N, Hamazaki Y.
  • Journal Title: PLoS One. Volume: 9 Pages: e90638
  • DOI: 10.1371/journal.pone.0090638
  • Peer Reviewed
• [Journal Article] Meis1 is required for the maintenance of postnatal thymic epithelial cells. (2014)
  • Author(s): Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R.
  • Journal Title: PLoS One. Volume: 9 Pages: e89885
  • DOI: 10.1371/journal.pone.0089885
  • Peer Reviewed
• [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development. (2014)
  • Author(s): Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
  • Journal Title: PLoS One. Volume: 9 Pages: e89115
  • DOI: 10.1371/journal.pone.0089115
  • Peer Reviewed
• [Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis. (2014)
  • Author(s): Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
  • Journal Title: PLoS One. Volume: 9 Pages: e87646
  • DOI: 10.1371/journal.pone.0087646
  • Peer Reviewed
• [Journal Article] Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module. (2014)
  • Author(s): Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M, Ose T.
  • Journal Title: PLoS One. Volume: 9 Pages: e85875
  • DOI: 10.1371/journal.pone.0085875
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice. (2014)
  • Author(s): Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55 Pages: 4682-4690
  • DOI: 10.1167/iovs.13-13272
  • Peer Reviewed
• [Journal Article] NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. (2014)
  • Author(s): Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
  • Journal Title: Int Immunol. Volume: 26 Pages: 607-618
  • DOI: 10.1093/intimm/dxu062
  • Peer Reviewed
• [Journal Article] NKG2D functions as an activating receptor on natural killer cells in common marmoset (callithrix jacchus). (2014)
  • Author(s): Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y, Suzuki R, Ogasawara K.
  • Journal Title: Int Immunol. Volume: 26 Pages: 597-606
  • DOI: 10.1093/intimm/dxu053
  • Peer Reviewed
• [Journal Article] Increased number of Hassall's corpuscles in myasthenia gravis patients carrying thymic hyperplasia. (2014)
  • Author(s): Matsui N, Ohigashi I, Tanaka K, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
  • Journal Title: J Neuroimmunol. Volume: 269 Pages: 56-61
  • DOI: 10.1016/j.jneuroim.2014.01.011
  • Peer Reviewed
• [Journal Article] Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes. (2014)
  • Author(s): Sutoh Y, Kasahara M.
  • Journal Title: Immunogenetics. Volume: 66 Pages: 403-409
  • DOI: 10.1007/s00251-014-0773-6
  • Peer Reviewed
• [Journal Article] Corticomedullary differentiation and maturational arrest in thymomas. (2014)
  • Author(s): Storbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Schalke B, Kasahara M, Tomaru U, Marx A.
  • Journal Title: Histopathology. Volume: 64 Pages: 557-566
  • DOI: 10.1111/his.12279
  • Peer Reviewed
• [Journal Article] MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques. (2014)
  • Author(s): Ikeshita S, Miyatake Y, Otsuka N, Kasahara M.
  • Journal Title: Exp Mol Pathol. Volume: 97 Pages: 171-175
  • DOI: 10.1016/j.yexmp.2014.07.002
  • Peer Reviewed
• [Journal Article] Expression of thymoproteasome subunit β5t in type AB thymoma. (2014)
  • Author(s): Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y.
  • Journal Title: J Clin Pathol. Volume: 67 Pages: 276-278
  • DOI: 10.1136/jclinpath-2013-201930
  • Peer Reviewed
• [Journal Article] Alpha-smooth muscle actin expression identifies subpopulations of lymph node non-hematopoietic cells. (2014)
  • Author(s): Togoo K, Takahama Y, Takada K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 449 Pages: 241-247
  • DOI: 10.1016/j.bbrc.2014.05.023
  • Peer Reviewed
• [Journal Article] Environments of B cell development. (2014)
  • Author(s): Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grun J. R, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K , Melchers F.
  • Journal Title: Immunol Lett. Volume: 157 Pages: 60-63
  • DOI: 10.1016/j.imlet.2013.11.011
  • Peer Reviewed
• [Journal Article] Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development. (2014)
  • Author(s): Nakahara R, Kawai Y, Oda A, Nishimura M, Murakami A, Azuma T, Kaifu T, Goitsuka, R.
  • Journal Title: Genesis. Volume: 52 Pages: 916-923
  • DOI: 10.1002/dvg.22829
  • Peer Reviewed
• [Journal Article] Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody. (2014)
  • Author(s): Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, Nunomura S, Okayama Y, Tanaka M, Kitagawa H, Kulski JK, Inoko H, Ando A, Kametani Y.
  • Journal Title: Biosci Trends. Volume: 8 Pages: 308-315
  • DOI: 10.5582/bst.2014.01084
  • Peer Reviewed
• [Journal Article] Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma. (2014)
  • Author(s): Goto Y, Kametani Y, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M.
  • Journal Title: Biosci Trends. Volume: 8 Pages: 93-100
  • Peer Reviewed
• [Journal Article] PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin. (2014)
  • Author(s): Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
  • Journal Title: Protein Expres Purif. Volume: 95 Pages: 240-247
  • DOI: 10.1016/j.pep.2014.01.009
  • Peer Reviewed
• [Journal Article] The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo. (2014)
  • Author(s): Laurin M, Dumouchel A, Fukui Y, Cote J-F.
  • Journal Title: Small GTPases Volume: 4 Pages: 221-230
  • DOI: 10.4161/sgtp.27430
  • Peer Reviewed
• [Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8. (2014)
  • Author(s): Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
  • Journal Title: Immunity, Inflammation and Disease. Volume: 2 Pages: 35-43
  • DOI: 10.1002/iid3.17
  • Peer Reviewed
• [Remarks] 免疫四次元空間ダイナミクス
  • URL: http://www.genome.tokushima-u.ac.jp/ion/index.html