2019 Fiscal Year Final Research Report

Developments of Extremely Difficult Substrate Conversion Reactions through Activation of Unreactive Bonds

Planned Research

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Project Area	Precise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions
Project/Area Number	15H05799
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Science and Engineering
Research Institution	Kyoto University
Principal Investigator	Nakao Yoshiaki 京都大学, 工学研究科, 教授 (60346088)
Project Period (FY)	2015-06-29 – 2020-03-31
Keywords	高難度分子変換 / 不活性結合活性化
Outline of Final Research Achievements	Catalytic direct functionalization of unreactive C-H, C-C, C-N, and C-O bonds, which are ubiquitous in organic molecules, is highly useful in organic synthesis in terms of atom- and step-economy. Much attention has been paid to these transformations and many research groups have reported various methods using different metal catalysts. Nevertheless, many of known protocols rely on the use of substrates having coordinating functional groups to direct metal catalysts and/or strains to be relieved to cleave such unreactive bonds. In this project, we have developed the synthetic organic transformations involving activation of these bonds in readily available conventional organic molecules, without using substrates specially prepared.
Free Research Field	有機合成化学
Academic Significance and Societal Importance of the Research Achievements	本研究では，配向基や分子構造の歪みの解放を利用することなく，Ar-H，Ar-NO2，Ar-O結合を官能基化できるPdおよびNi触媒を開発し，これまで報告例のなかった高難度精密有機合成反応の創出に成功した。いずれも，「基質の工夫」に頼る必要のない分子変換であり，有機合成化学における学術的成果として意義深い。従来の化学プロセスを革新して，省資源，省エネルギー型の物質生産に寄与しうる点において，社会的意義も有する成果である。