Design of Catalytically Active Sites for Multi-Centers Control and Their Application to Organic Transformation

2019 Fiscal Year Final Research Report

• Project Area: Precise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions
• Project/Area Number: 15H05802
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Hokkaido University
• Principal Investigator: Matsunaga Shigeki 北海道大学, 薬学研究院, 教授 (50334339)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: 精密制御触媒 / 不斉合成 / 不斉触媒 / 触媒活性点 / 炭素-水素結合活性化 / C-H官能基化 / 遷移金属触媒 / キラル酸

Outline of Final Research Achievements

In this research program, we have succeeded in developing precisely designed catalyst active center towards activation of inert C-H bonds in enantioselective manner. By designing bimetallic catalysts bearing two or more metals in precisely designed position as well as chiral hybrid catalysts of cationic metal complex and chiral organo-anion, we suceeded in concise synthesis of useful building blocks for biologically active molecules. Through collaborative works in this research field, we clarified the reaction mechanism of our newly developed precisely designed catalysts.

Free Research Field

薬系化学

Academic Significance and Societal Importance of the Research Achievements

本研究課題では、精密に設計した触媒活性点を創出することで不活性な炭素-水素結合の活性化を伴う官能基化反応における立体制御を実現した。従来の合成化学的手法と比較し、不活性な炭素-水素結合の活性化を経ることで短い工程数で有用化合物の合成が可能となった。また、従来、立体制御が難しかった不活性な炭素-水素結合の官能基化において立体制御を可能としたことで、医薬品などの合成への応用可能性が開かれることとなった。