2020 Fiscal Year Final Research Report
Creation of Glycoconjugated Meddle Molecules for Realizing Glyco-medicine
Project Area | Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis. |
Project/Area Number |
15H05836
|
Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
Allocation Type | Single-year Grants |
Review Section |
Science and Engineering
|
Research Institution | Osaka University |
Principal Investigator |
Fukase Koichi 大阪大学, 理学研究科, 教授 (80192722)
|
Co-Investigator(Kenkyū-buntansha) |
下山 敦史 大阪大学, 理学研究科, 助教 (90625055)
真鍋 良幸 大阪大学, 理学研究科, 助教 (00632093)
|
Project Period (FY) |
2015-06-29 – 2020-03-31
|
Keywords | 中分子 / 糖鎖 / 反応集積 |
Outline of Final Research Achievements |
We have synthesized many glycans and glycoconjugates. We also evaluate their biological functions. In this study, we developed a highly efficient method for the synthesis of useful glycans and glycoconjugates using integrated synthesis to achieve a quantitative supply of these compounds. Immunological function of synthesized compounds was also evaluated. In addition, we created various glycoconjugates, including cancer vaccines. These functional-integrated middle molecules have emergent functions. These compounds are expected to be the seeds of next-generation drugs. These studies were carried out in collaboration with a number of researchers.
|
Free Research Field |
天然物化学
|
Academic Significance and Societal Importance of the Research Achievements |
糖鎖は,感染,炎症,生体防御,がんなどの重要な生命現象に関与するが,構造が複雑でかつ多くの場合不均一であるために,分子構造に基づいた生物機能解明が大きな研究課題である.また近年,糖鎖は医薬品のターゲットとして重要視されているが,合成による量的供給が困難であるため,糖鎖医薬はほとんど実現されていない.本研究で,糖鎖合成の基盤技術を発展させたことで,糖鎖合成を大きく効率化することができた.加えて,糖鎖による免疫制御を積極的に検討し,糖鎖医薬のシーズとなる化合物の創製にも成功した.これらの成果は,糖鎖科学の発展のみならず,有機合成化学から,生物学,免疫学に及ぶ幅広い分野に大きなインパクトを与えた.
|