2019 Fiscal Year Final Research Report
Development of precise synthetic reaction by reaction integration using a dissipative structure system
| Project Area | Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis. |
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| Project/Area Number |
15H05845
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浅野 圭佑 京都大学, 工学研究科, 助教 (90711771)
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| Project Period (FY) |
2015-06-29 – 2020-03-31
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| Keywords | 反応集積化 / 有機分子触媒 / 動的速度論的分割 / 光学活性複素環 / 軸不斉化合物 / キュバン / キラルキュバン |
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| Outline of Final Research Achievements |
A middle-sized molecule is effective in inhibiting protein-protein interactions, which cause various diseases; it should have hydrophobic groups to extend in at least three directions in order to interact with protein surface in a wide range. Therefore, we paid attention to three kinds of molecules, those are a molecule with multiple chiral centers, an axial chiral molecule, and an asymmetric cubic molecule, were synthesized very efficiently by the reaction integration method. To achieve this goal, we also investigated the flow method, which means a dissipative structure, but the tandem reaction in which the reactive species were automatically controlled was effective.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
中分子医薬を指向した研究を行った結果、広範な領域でタンパクと相互作用するために、複数の不斉中心を有する分子・軸不斉分子・不斉正立方体分子の新規合成法を開発することができた。この合成法は、通常複数の反応を組み合わせて段階的に行うが、本研究では、複数の反応を触媒の工夫、活性種の工夫を行うことにより可能にした。作り上げた分子は、そのものが直接中分子医薬になるものではないものの、新規な高立体選択的反応の概念を提案することができた。
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