recording and analysis of neuronal oscillation in humans

2016 Fiscal Year Annual Research Report

• Project Area: Non-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
• Project/Area Number: 15H05874
• Research Institution: Kyoto University
• Principal Investigator: 池田 昭夫 京都大学, 医学研究科, 特定教授 (90212761)
• Co-Investigator(Kenkyū-buntansha): 長峯 隆 札幌医科大学, 医学部, 教授 (10231490) ; 小林 勝弘 岡山大学, 医歯薬学総合研究科, 教授 (60273984) ; 國枝 武治 愛媛大学, 医学研究科, 教授 (60609931) ; 松本 理器 京都大学, 医学研究科, 准教授 (00378754)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: 脳・神経 / 神経科学 / 脳神経疾患 / 複雑系工学

Outline of Annual Research Achievements

病的大脳皮質領野レベルでは、皮質脳波の広域周波数帯域解析を継続した。1)臨床データで能動的と受動的DC電位の概念を導入することにほぼ成功し、動物データで検討中である。2)DC電位とHFOの相互作用がてんかん原性に関わることを昨年見いだしたが、多数例の解析を効率的に進めるため自動検出プログラムを開発した（国内学会発表）。3)発作時DC電位、HFOの３次元電流源推定を行い、HFOよりもDC電位の電流源が画像・脳磁図による病変とより合致することを明らかにした（国内学会発表）。
皮質の高周波の振動現象に関して、1)覚醒時より徐波睡眠期に低周波との異周波数間結合が強まることを明らかにした（国内学会発表）。2)皮質単発電気刺激の手法を用いて、皮質・皮質間伝播を介した外的入力が皮質の振動現象に及ぼす影響を検討した。てんかん焦点で誘発される高周波活動のパワーが非焦点皮質より有意に高く、皮質興奮性の指標として発作間欠期のてんかん原性バイオマーカー候補と示唆された(論文改訂中)。3)刺激誘発性高周波活動の挙動から、レム睡眠内の急速眼球運動出現時は覚醒時により近いことを明らかにした (論文発表)。4)課題下の皮質脳律動のデコーディングから、同側運動や意味記憶にかかわる神経基盤を明らかにした(論文発表)。
時相的振動解析から、1)ヒト脳の発達段階におけるてんかん性脳症の頭皮脳波を解析し、非侵襲的に検出される病的HFOの有無と棘波の双極子発生源の有意な関連(論文発表)、2)点頭てんかんの病的HFO発生時相と発作時徐波の位相の連関を示し(論文発表)、小児期の病態とHFO 特性を解明した。
外的な律動制御法として、焦点への皮質電気刺激や迷走神経刺激が臨床応用として、1)迷走神経刺激の作動原理に脳電位の陽性変位が関連することを明らかにした (論文改訂中)。2)50 Hz電気刺激がてんかん関連の広域周波数帯域脳活動を抑制し、棘波を減らすことを明らかにした（国内学会発表）。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

てんかん病態において、１）DC電位に能動的と受動的DC電位の概念を導入することができた。２）低周波数と高周波数の振動現象が発作時のみならず発作間欠期においても密接に関わることを示すことができ、発作発現に至る病的遷移の解明に向けて解析が進んだ。３）生理的および、病態下の振動現象について異周波数間結合の解析を用いて、皮質領域内の低周波数と高周波数間におけるクロストークが覚醒・睡眠段階に応じて変容し、深睡眠期に強まることを明らかにした。４）病的および生理的振動現象の異周波数間の情報伝達の方向性を明らかにするため、B班と共同で移動エントロピーの解析を開始した。発作時の数理モデルの構築を目的してB班へのデータ提供を開始し、HFOを表現するモデル方程式を確立するための解析に着手し、ついでDC電位のグリアとの関連をさらにモデル化予定である。
皮質領域間の脳律動現象に関しては、１）単発刺激を外的入力のモデルとすることで、ヒト大脳皮質に誘発される高周波の振動動態を明らかにし、２）てんかん焦点での皮質興奮性の変容、およびレム睡眠期の変容を解明中である。
局所神経回路レベルでは、１）てんかんモデル動物（常染色体優性外側側頭葉てんかんモデルラット）におけるミクロ及びマクロ脳波記録に着手し、てんかん発症過程において、グリア細胞のカリウム緩衝機能が障害されていることを免疫組織化学的に明らかにした。
時相的な観点から、１）発達段階の小児てんかん患者で、頭皮記録から解析可能な病的HFOの分布と病変の関係を、病理像の特性と関連を明らかにした。
内的・外的律動制御の作動原理の解明に関しては、１）50 Hz電気刺激がてんかん関連の広周波数帯域の脳活動を抑制することを明らかにし、２）迷走神経刺激を用いた外的な律動制御の作動原理に脳電位の陽性変位が関連することを見いだした。

Strategy for Future Research Activity

大脳皮質領野レベルでは、1)発作時の能動的と受動的DC電位を実データとモデル解析の両者からの検索と検証、2)皮質脳波の広域周波数継続し、低周波数と高周波数の振動現象の出現様式・相互作用の観点から、発作間欠期からてんかん発作への遷移の動態を明らかにする。3)覚醒・睡眠段階に応じた異周波数間結合の変容について、解剖学的な意義付け、正常・てんかん皮質における差異を明らかにする。生理機能発現時の振動現象の計測・解析を継続する。
皮質領域間の脳律動現象に関しては、1)単発皮質電気刺激を外的入力のモデルとして全電極の網羅的解析から、てんかん原性バイオマーカーとしての刺激誘発性高周波活動の有用性を検証する。2)ヒトてんかん焦点における興奮・抑制変容機構の解明を目指す。
上記の振動現象の数理モデル構築を目的としてB班との密な連携を継続する。1)てんかん発作時のHFOとDC電位を含めて表現できるモデル方程式を導出し、数理マーカー候補の選定を目指す。2)生理的振動現象に関しては、高次脳機能遂行下のeffective connectivity解析を推進する。
局所神経回路レベルでは、1)てんかんモデルラットの広域周波数帯域局所電場電位と活動電位記録を継続し、両者の相互作用、刺激外乱による振動現象変容、振動現象の発生基盤の病理組織的変化を探る。
時相的な観点から、1)ヒト脳の発達段階に特有のてんかん性脳症を含む患者で、HFOとてんかん性脳症発現機構の関連を解明する。2)病変部位、発達段階や脳障害との関連を分析し、神経ネットワークを病的HFOが阻害する過程を明らかにする。3)病的HFO発生機構の解明に、イオンチャネルの遺伝子変異モデル動物と神経ネットワークのシミュレーションを用いた研究の準備に着手する。
外的な律動制御に関して、C班と連携し局所とネットワークレベルの生理的および病的振動の変容を、てんかんの病勢変化、記憶など機能変化と関連させて解析する。

Research Products

• [Int'l Joint Research] Istituto Neurologico Carlo Besta(Italy)
  • Country Name: Italy
  • Counterpart Institution: Istituto Neurologico Carlo Besta
• [Int'l Joint Research] Institut de Neurosciences des Systemes/INSERM(France)
  • Country Name: France
  • Counterpart Institution: Institut de Neurosciences des Systemes/INSERM
• [Int'l Joint Research] Johns Hopkins University/Cleveland Clinic Epilepsy Center/University of Michigan(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Johns Hopkins University/Cleveland Clinic Epilepsy Center/University of Michigan
• [Int'l Joint Research] University of Manchester(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: University of Manchester
• [Journal Article] 辺縁系脳炎で発症した神経梅毒の1例 (2017)
  • Author(s): 月田 和人、下竹 昭寛、中谷 光良、高橋 幸利、池田 昭夫、高橋 良輔
  • Journal Title: 臨床神経学 Volume: 57 Pages: 37-40
  • DOI: 10.5692/clinicalneurol.cn-000936
  • Peer Reviewed
• [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway. (2017)
  • Author(s): Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Mapping. Volume: 38 Pages: 1977-1991
  • DOI: doi: 10.1002/hbm.23498
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals: report from the ILAE-AES joint translational task force (2017)
  • Author(s): Moyer JT, Gnatkovsky V, Ono T, Otáhal J, Wagenaar J, William C. Stacey W, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS
  • Journal Title: Epilepsia Volume: 58 Pages: 53-67
  • DOI: 10.1111/epi.13909
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] How to record high frequency oscillations in epilepsy: a practical guideline (2017)
  • Author(s): Zijlmans M, Worrell G, Duempelmann M, Stieglitz T, Barborica A, Heers M, Ikeda A, Usui N, Le Van Quyen M
  • Journal Title: Epilepsia Volume: 58(8) Pages: 1305-1315
  • DOI: 10.1111/epi.13814
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity (2017)
  • Author(s): Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
  • Journal Title: Clin Neurophysiol Volume: 128 Pages: 734-743
  • DOI: 10.1016/j.clinph.2017.01.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Population pharmacokinetics of topiramate in Japanese pediatric and adult patients with epilepsy using routinely monitored data. (2017)
  • Author(s): Takeuchi M, Yano I, Ito S, Sugimoto M, Yamamoto S, Yonezawa A, Ikeda A, Matsubara K
  • Journal Title: Ther Drug Monit Volume: 39 Pages: 124-131
  • DOI: 10.1097/FTD.0000000000000383
  • Peer Reviewed
• [Journal Article] Convergence paralysis caused by a localized cerebral infarction affecting the white matter underlying the right frontal eye field (2017)
  • Author(s): Kinoshita H, Maki T, Hata M, Nakayama Y, Yamashita H, Sawamoto N, Ikeda A, Takahashi R
  • Journal Title: Neurol Sci Volume: 375 Pages: 94-96
  • DOI: 10.1016/j.jns.2017.01.054
  • Peer Reviewed
• [Journal Article] Nicotine elicits convulsive seizures by activating amygdalar neurons. (2017)
  • Author(s): Iha HA, Kunisawa N, Shimizu S, Tokudome K, Mukai T, Kinboshi M, Ikeda A, Ito H, Serikawa T, Ohno Y
  • Journal Title: Front Pharmacol Volume: 8 Pages: 57
  • DOI: 10.3389/fphar.2017.00057
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms. (2017)
  • Author(s): Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
  • Journal Title: Neuroimage Volume: 147 Pages: 302-313
  • DOI: 10.1016/j.neuroimage.2016.11.058
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Novel LGI1 mutation in a Japanese autosomal dominant lateral temporal lobe epilepsy family. (2017)
  • Author(s): Fumoto N, Matsumoto R, Kawamata J, Koyasu S, Kondo T, Shimotake A, Kitamura K, Koshiba Y, Kinoshita M, Kawasaki J, Yamashita H, Takahashi R, Ikeda A
  • Journal Title: Neurol Clin Neurosci Volume: 5 Pages: 44-45
  • DOI: 10.1111/ncn3.12105
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex, a single-pulse electrical stimulation study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Journal Title: SLEEP Volume: in press Pages: in press
  • Peer Reviewed / Open Access
• [Journal Article] We could predict good responders to vagus nerve stimulation: a surrogate marker by slow cortical potential shift (2017)
  • Author(s): Borgil B, Matsuhashi M, Fumuro T, Nohira H, Nakano N, Iida K, Katagiri M, Shimotake A, Matsumoto R, Kikuchi T, Kunieda T, Kato A, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy. (2017)
  • Author(s): Matsumoto R, Kunieda T, Nair D
  • Journal Title: Seizure Volume: 44 Pages: 27-36
  • DOI: 10.1016/j.seizure.2016.11.003
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A ten-year follow-up cohort study of childhood epilepsy: Changes in epilepsy diagnosis with age (2017)
  • Author(s): Hanaoka, Y., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Brain and Development Volume: 39 Pages: 312-320
  • DOI: 10.1016/j.braindev.2016.10.011
  • Peer Reviewed
• [Journal Article] Measurement of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children (2017)
  • Author(s): Akiyama, T., Akiyama, M., Hayashi, Y., Shibata, T., Hanaoka, Y., Toda, S., Imai, K., Hamano, S.-I., Okanishi, T., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Clinica Chimica Acta Volume: 466 Pages: 1-5
  • DOI: 10.1016/j.cca.2016.12.027
  • Peer Reviewed
• [Journal Article] Behavioral outcomes of school-aged full-term small-for-gestational-age infants: A nationwide Japanese population-based study (2017)
  • Author(s): Takeuchi, A., Yorifuji, T., Takahashi, K., Nakamura, M., Kageyama, M., Kubo, T., Ogino, T., Kobayashi, K., Doi, H.
  • Journal Title: Brain and Development Volume: 39 Pages: 101-106
  • DOI: 10.1016/j.braindev.2016.08.007
  • Peer Reviewed
• [Journal Article] Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children (2017)
  • Author(s): Akiyama, T., Hayashi, Y., Hanaoka, Y., Shibata, T., Akiyama, M., Nakamura, K., Tsuyusaki, Y., Kubota, M., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Clinica Chimica Acta Volume: 465 Pages: 5-10
  • DOI: 10.1016/j.cca.2016.12.005
  • Peer Reviewed
• [Journal Article] A case of Dravet syndrome with cortical myoclonus indicated by jerk-locked back-averaging of electroencephalogram data (2017)
  • Author(s): Kobayashi, Y., Hanaoka, Y., Akiayma, T., Ohmori, I., Ouchida, M., Yamamoto, T., Oka, M., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Brain and Development Volume: 39 Pages: 75-79
  • DOI: 10.1016/j.braindev.2016.07.005
  • Peer Reviewed
• [Journal Article] A Japanese case of β-ureidopropionase deficiency with dysmorphic features (2017)
  • Author(s): Akiyama, T., Shibata, T., Yoshinaga, H., Kuhara, T., Nakajima, Y., Kato, T., Maeda, Y., Ohse, M., Oka, M., Kageyama, M., Kobayashi, K.
  • Journal Title: Brain and Development Volume: 39 Pages: 58-61
  • DOI: 10.1016/j.braindev.2016.08.001
  • Peer Reviewed
• [Journal Article] CCEPオフライン解析と解釈（特集「CCEPのskills workshop：clinical practice parameter（臨床実践指標）を目指して）． (2017)
  • Author(s): 小林勝哉，松本理器，松橋眞生，中江卓郎，宇佐美清英，山尾幸広，菊池隆幸，吉田和道，國枝武治，池田昭夫．
  • Journal Title: 臨床神経生理学 Volume: 42 Pages: 91-101
  • Open Access
• [Journal Article] 日本神経学会における脳波判読セミナー受講者のアンケート調査：脳波教育の過去5年間の実態，ニーズおよびその変遷 (2017)
  • Author(s): 谷岡洸介, 人見健文, 松本理器, 高橋良輔, 飛松省三, 犬塚貴, 吉良潤一, 楠進, 池田昭夫
  • Journal Title: 臨床神経 Volume: 57 Pages: 110-117
  • DOI: 10.5692/clinicalneurol.cn-000990.
  • Peer Reviewed / Open Access
• [Journal Article] Methodological standards and interpretation of video-EEG in adult control rodents. A TASK1-WG1 report of the AES/ILAE Translational Task Force of the ILAE (2017)
  • Author(s): Shilpa K, D'Ambrosio R, Duveau V, Roucard, Corinne R, Garcia-Cairasco N, Ikeda A, de Curtis M, Galanopoulou A, Kelly K
  • Journal Title: Epilepsia Volume: in press Pages: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Methodological standards for in vitro models of epilepsy and epileptic seizures (2017)
  • Author(s): Raimondo JV, Heinemann U, de Curtis M, Goodkin HP, Dulla CG, Janigro D, Ikeda A, Lin CCK, Jiruska P, Galanopoulou AS, Bernard C, TASK1-WG4 group of the AES/ILAE Translational Task Force of the Neurobiology Commission of the ILAE
  • Journal Title: Epilepsia Volume: in press Pages: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Phantom of oscillation: Operational definition bound to improve. editorial. (2017)
  • Author(s): Kinoshita M, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 127 Pages: 8-9
  • DOI: 10.1016/j.clinph.2015.05.020
  • Peer Reviewed
• [Journal Article] 抗てんかん薬，新薬展望2017，第III部 治療における最近の新薬の位置付け〈薬効別〉-新薬の広場- (2017)
  • Author(s): 矢野育子，池田昭夫
  • Journal Title: 医薬ジャーナル Volume: in press Pages: in press
• [Journal Article] 脳卒中後てんかん，脳血管障害に伴う慢性期症状の管理，日本医師会雑誌，特別号1 (2017)
  • Author(s): 田中智貴，松本理器，池田昭夫
  • Journal Title: 生涯教育シリーズ Volume: in press Pages: in press
• [Journal Article] てんかんを疑う症状と診断 (2017)
  • Author(s): 音成秀一郎，池田昭夫
  • Journal Title: 日本医師会雑誌 Volume: in press Pages: in press
• [Journal Article] てんかん問題解説，神経内科専門医試験間題解答と解説，日本神経学会編 (2017)
  • Author(s): 池田昭夫
  • Journal Title: 南江堂 Volume: in press Pages: in press
• [Journal Article] 実践 ! 神経救急(neurocritical care)，てんかんの診断 (2017)
  • Author(s): 音成秀一郎，池田昭夫
  • Journal Title: 『診断と治療』特集 Volume: 105 Pages: 35-41
• [Journal Article] フィコンパ（ペランパネル），連載企画「注目の新薬」 (2017)
  • Author(s): 藤井大樹，池田昭夫
  • Journal Title: 診断と治療 Volume: 105 Pages: 399-403
• [Journal Article] Appropriate conversion from valproate monotherapy to lamotrigine monotherapy in Japanese women with epilepsy. (2016)
  • Author(s): Yamamoto T, Kubota Y, Murayama H, Ozeki H, Numachi Y, Ikeda A, the Lamictal 200776 Study Group
  • Journal Title: Epilepsy & Seizure Volume: 8 Pages: 21-31
  • DOI: 10.3805/eands.8.21
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Right parietal source in Mahjong-induced seizure: a system epilepsy of focal origin. (2016)
  • Author(s): Fukuma K, Ihara M, Miyashita K, Motoyama R, Tanaka T, Kajimoto K, Ikeda A, Nagatsuka K
  • Journal Title: Clin Case Rep Volume: 4 Pages: 948-951
  • DOI: 10.1002/ccr3.653
  • Peer Reviewed / Open Access
• [Journal Article] The ‘when’ and ‘where’ of semantic coding in the anterior temporal lobe: Temporal representational similarity analysis of electrocorticogram data. (2016)
  • Author(s): Chen Y, Shimotake A, Matsumoto R, Kunieda T, Kikuchi T, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A, Lambon-Ralph MA
  • Journal Title: Cortex Volume: 79 Pages: 1-13
  • DOI: 10.1016/j.cortex.2016.02.015.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Population pharamacokinetic modeling of levetiracetam in pediatric and adult patients with epilepsy by using routinely monitored data. (2016)
  • Author(s): Ito S, Yano I, Hashi S, Tsuda M, Sugimoto M, Yonezawa A, Ikeda A, Matsubara K
  • Journal Title: Ther Drug Monit Volume: 38 Pages: 371-378
  • DOI: 10.1097/FTD.0000000000000291.
  • Peer Reviewed
• [Journal Article] Epileptic network of hypothalamic hamartoma: An EEG-fMRI study. (2016)
  • Author(s): Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A
  • Journal Title: Epilepsy Res Volume: 125 Pages: 1-9
  • DOI: 10.1016/j.eplepsyres.2016.05.011.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy. (2016)
  • Author(s): Hitomi T, Kobayashi K, Sakurai T, Ueda S, Jingami N, Kanazawa K, Matsumoto R, Takahashi R, Ikeda A
  • Journal Title: Epileptic Disord Volume: 18 Pages: 67-72
  • DOI: 10.1684/epd.2016.0807.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An elderly woman with exaggerated startle reflex and unconscious drop attack. (2016)
  • Author(s): Neshige S, Kobayashi K, Shimotake A, Iemura T, Matsumoto R, Nishinaka K, Matsumoto M, Takahashi R, Ikeda A
  • Journal Title: Neurol Clin Neurosci Volume: 4 Pages: 156-158
  • DOI: 10.1111/ncn3.12055
  • Peer Reviewed / Open Access
• [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy. (2016)
  • Author(s): Imamura H, Matsumoto R, Takaya S, Nakagawa T, Shimotake A, Kikuchi T, Sawamoto N, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Epilepsy Res Volume: 18 Pages: 65-72
  • DOI: 10.1016/j.eplepsyres.2015.12.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Paraneoplastic limbic encephalitis in a human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy: a case report and literature review. (2016)
  • Author(s): Uneno Y, Yokoyama A, Nishikawa Y, Funakoshi T, Ozaki Y, Aoyama I, Yamaguchi D, Morita S, Mori Y, Kanai M, Kinoshita H, Inoue T, Sawamoto N, Matsumoto R, Matsumoto S, Muto M
  • Journal Title: Intern Med Volume: 55 Pages: 2605-2609
  • DOI: 10.2169/internalmedicine.55.6917
  • Peer Reviewed / Open Access
• [Journal Article] Status epilepticus in the elderly: Prognostic implications of rhythmic and periodic patterns in electroencephalography and hyperintensities on diffusion-weighted imaging. (2016)
  • Author(s): Yoshimura H, Matsumoto R, Ueda H, Ariyoshi K, Kawamoto M, Ishii J, Ikeda A, Takahashi R, Kohara N.
  • Journal Title: J Neurol Sci Volume: 370 Pages: 284-289
  • DOI: 10.1016/j.jns.2016.09.062
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fast (40 - 150Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome (2016)
  • Author(s): Kobayashi, K., Akiyama, T., Oka, M., Endoh, F., Yoshinaga, H.
  • Journal Title: Brain and Development Volume: 38 Pages: 909-914
  • DOI: 10.1016/j.braindev.2016.05.005
  • Peer Reviewed
• [Journal Article] A study on spike focus-dependence of high-frequency activity in idiopathic focal epilepsy in childhood. (2016)
  • Author(s): Shibata T, Yoshinaga H, Akiyama T, Kobayashi K.
  • Journal Title: Epilepsia Volume: 1 Pages: 121-125
  • DOI: 10.1002/epi4.12014
  • Peer Reviewed / Open Access
• [Journal Article] Cytokine-related and sodium channel polymorphism as candidate predisposing factors for childhood encephalopathy FIRES/AERRPS (2016)
  • Author(s): Saitoh, M., Kobayashi, K., Ohmori, I., Tanaka, Y., Tanaka, K., Inoue, T., Horino, A., Ohmura, K., Kumakura, A., Takei, Y., Hirabayashi, S., Kajimoto, M., Uchida, T., Yamazaki, S., Shiihara, T., Kumagai, T., Kasai, M., Terashima, H., Kubota, M., Mizuguchi, M.
  • Journal Title: Journal of the Neurological Sciences Volume: 368 Pages: 272-276
  • DOI: 10.1016/j.jns.2016.07.040
  • Peer Reviewed
• [Journal Article] Determination of CSF 5-methyltetrahydrofolate in children and its application for defects of folate transport and metabolism (2016)
  • Author(s): Akiyama, M., Akiyama, T., Kanamaru, K., Kuribayashi, M., Tada, H., Shiokawa, T., Toda, S., Imai, K., Kobayashi, Y., Tohyama, J., Sakakibara, T., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Clinica Chimica Acta Volume: 460 Pages: 120-125
  • DOI: 10.1016/j.cca.2016.06.032
  • Peer Reviewed
• [Journal Article] Idiopathic focal epilepsies: The lost tribe (2016)
  • Author(s): Pal, D.K., Ferrie, C., Addis, L., Akiyama, T et al.
  • Journal Title: Epileptic Disorders Volume: 18 Pages: 252-288
  • DOI: 10.1684/epd.2016.0839
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Japanese case of hereditary chin trembling responsive to arotinolol (2016)
  • Author(s): Akiyama, T., Miyahara, H., Waki, K., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Parkinsonism and Related Disorders Volume: 29 Pages: 133-134
  • DOI: 10.1016/j.parkreldis.2016.04.021
  • Peer Reviewed
• [Journal Article] A novel HYLS1 homozygous mutation in living siblings with Joubert syndrome (2016)
  • Author(s): Oka, M., Shimojima, K., Yamamoto, T., Hanaoka, Y., Sato, S., Yasuhara, T., Yoshinaga, H., Kobayashi, K.
  • Journal Title: Clinical Genetics Volume: 89 Pages: 739-743
  • DOI: 10.1111/cge.12752
  • Peer Reviewed
• [Journal Article] Surgical versus medical treatment for children with epileptic encephalopathy in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study) (2016)
  • Author(s): Otsuki, T., Kim, H.-D., Luan, G., Inoue, Y., Baba, H., Oguni, H., Hong, S.-C., Kameyama, S., Kobayashi, K., Hirose, S., Yamamoto, H., Hamano, S.-I., Sugai, K.
  • Journal Title: Brain and Development Volume: 38 Pages: 449-460
  • DOI: 10.1016/j.braindev.2015.11.004
  • Peer Reviewed
• [Journal Article] The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes (2016)
  • Author(s): Jacobs, J., Vogt, C., LeVan, P., Zelmann, R., Gotman, J., Kobayashi, K.
  • Journal Title: Clinical Neurophysiology Volume: 127 Pages: 129-142
  • DOI: 10.1016/j.clinph.2015.04.053
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Occurrence of bilaterally independent epileptic spasms after a corpus callosotomy in West syndrome (2016)
  • Author(s): Kobayashi, K., Endoh, F., Toda, Y., Oka, M., Baba, H., Ohtsuka, Y., Yoshinaga, H.
  • Journal Title: Brain and Development Volume: 38 Pages: 132-135
  • DOI: 10.1016/j.braindev.2015.05.003
  • Peer Reviewed
• [Journal Article] Predictive factors for relapse of epileptic spasms after adrenocorticotropic hormone therapy in West syndrome (2016)
  • Author(s): Hayashi, Y., Yoshinaga, H., Akiyama, T., Endoh, F., Ohtsuka, Y., Kobayashi, K.
  • Journal Title: Brain and Development Volume: 38 Pages: 32-39
  • DOI: 10.1016/j.braindev.2015.05.012
  • Peer Reviewed
• [Journal Article] SSADH deficiency possibly associated with enzyme activity-reducing SNPs (2016)
  • Author(s): Akiyama, T., Osaka, H., Shimbo, H., Kuhara, T., Shibata, T., Kobayashi, K., Kurosawa, K., Yoshinaga, H.
  • Journal Title: Brain and Development Volume: 38 Pages: 871-874
  • DOI: 10.1016/j.braindev.2016.03.008
  • Peer Reviewed
• [Journal Article] Load effect on background rhythms during motor execution: A magnetoencephalographic study. (2016)
  • Author(s): Toyoshima T, Yazawa S, Murahara T, Ishiguro M, Shinozaki J, Ichihara-Takeda S, Shiraishi H, Matsuhashi M, Shimohama S, Nagamine T
  • Journal Title: Neurosci Res. Volume: 112 Pages: 26-36
  • DOI: 10.1016/j.neures.2016.06.002
  • Peer Reviewed
• [Journal Article] Impact of language on functional connectivity for audiovisual speech integration. (2016)
  • Author(s): Shinozaki J, Hiroe N, Sato MA, Nagamine T, Sekiyama K.
  • Journal Title: Sci Rep. Volume: 11 Pages: -
  • DOI: 10.1038/srep31388
  • Peer Reviewed / Open Access
• [Journal Article] Neuromodulatory Role of Revascularization Surgery in Moyamoya Disease. (2016)
  • Author(s): Noshiro S, Mikami T, Komatsu K, Kanno A, Enatsu R, Yazawa S, Nagamine T, Matsuhashi M, Mikuni N.
  • Journal Title: World Neurosurg Volume: 91 Pages: 473-482
  • DOI: 10.1016/j.wneu.2016.04.087.
  • Peer Reviewed
• [Journal Article] バラシクロビルによる一過性の周期性同期性放電を伴う薬剤性脳症をきたした高齢者例 (2016)
  • Author(s): 中谷光良, 月野光博, 高橋良輔, 池田昭夫
  • Journal Title: 臨床神経 Volume: 56 Pages: 504-507
  • DOI: 10.5692/clinicalneurol.cn-000892
  • Peer Reviewed / Open Access
• [Journal Article] デジタル脳波の記録・判読指針，特集Ｉ 脳波～過去・現在・未来 (2016)
  • Author(s): 人見健文，松本理器，池田昭夫
  • Journal Title: 神経内科 Volume: 85 Pages: 402-409
• [Journal Article] 神経疾患治療ノート，特発性全般てんかん (2016)
  • Author(s): 太田真紀子，人見健文，池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 34 Pages: 1274-1276
• [Journal Article] wide-band EEGの時間周波数解析，目で見るてんかん (2016)
  • Author(s): 井内盛遠，池田昭夫
  • Journal Title: Epilepsy Volume: 10 Pages: 4-7
• [Journal Article] てんかんの診断と病型分類，てんかん：内科医が知っておくべき診療ポイントと治療の最前線 (2016)
  • Author(s): 池田昭夫
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 1348-1357
• [Journal Article] 皮質脳波記録 (2016)
  • Author(s): 下竹昭寛，國枝武治，松本理器
  • Journal Title: Clinical Neuroscience Volume: 34 Pages: 771-776
• [Journal Article] てんかん病態下の脳内ネットワーク (2016)
  • Author(s): 十川純平，松本理器，池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 34 Pages: 713-716
• [Journal Article] 本邦における高齢者てんかんの臨床的特徴 (2016)
  • Author(s): 音成秀一郎，池田昭夫
  • Journal Title: 新薬と臨牀 Volume: 65 Pages: 840-845
• [Journal Article] 皮質電気刺激によるヒト脳機能ネットワークの探索 (2016)
  • Author(s): 山尾幸広，國枝武治，松本理器
  • Journal Title: 脳神経外科速報 Volume: 25 Pages: 411-420
• [Journal Article] 特集「これからのてんかん医療～ペランパネルへの期待～」，AMPA受容体とてんかん原性(病態) (2016)
  • Author(s): 藤井大樹，池田昭夫
  • Journal Title: クリニシアン Volume: 649 Pages: 29-35
• [Journal Article] 特集：神経生理最前線，てんかん外科における術前皮質・白質機能マッピング (2016)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，國枝武治
  • Journal Title: 最新精神医学 Volume: 21 Pages: 101-109
• [Journal Article] てんかん発作の発現機構:red slow はあるか? (2016)
  • Author(s): 池田昭夫
  • Journal Title: 脳神経外科ジャーナル Volume: 25 Pages: 128-136
• [Journal Article] AES2015印象記 (2016)
  • Author(s): 池田昭夫
  • Journal Title: 第69回米国てんかん学会記録集 Volume: 1 Pages: 1-2
• [Journal Article] 編集後記 (2016)
  • Author(s): 池田昭夫
  • Journal Title: 臨床神経 Volume: 56 Pages: 307
• [Presentation] CCEPのオフライン解析と解釈（ワークショップ2 CCEPのskills workshop：clinical practice parameter（臨床実践指標）を目指して）． (2017)
  • Author(s): 松本理器，小林勝哉，菊池隆幸，國枝武治，池田昭夫
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2017-10-27 – 2017-10-29
• [Presentation] てんかんの臨床神経生理学と硬膜下電極（エキスパートレクチャー12） (2017)
  • Author(s): 松本理器，下竹昭寛，吉田和道，松橋眞生，國枝武治，池田昭夫
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2017-10-27 – 2017-10-29
• [Presentation] てんかん原性の臨床生理学的biomarker：red slowはあるか？（教育講演11） (2017)
  • Author(s): 池田昭夫
  • Organizer: 第４２回日本臨床神経生理学会
  • Place of Presentation: 郡山
  • Year and Date: 2017-10-27 – 2017-10-29
• [Presentation] Epileptogenicity and related network: Approach from “interventional” clinical neurophysiology. Translatability between basic&clinical studies for the pathophysiology of epilepsy: Approach from Oscillology (2017)
  • Author(s): Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Ikeda A
  • Organizer: The 94th Annual meeting of the Physiological Society of Japan
  • Place of Presentation: 浜松
  • Year and Date: 2017-03-28
• [Presentation] 神経救急としてのてんかん重積状態（教育講演34） (2017)
  • Author(s): 松本理器
  • Organizer: 第42回日本脳卒中学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-18
• [Presentation] 神経疾患治療トレンド考２：てんかん (2017)
  • Author(s): 松本理器
  • Organizer: 平成28年度日本神経学会東海北陸地区生涯教育講演会
  • Place of Presentation: 名古屋
  • Year and Date: 2017-03-12
• [Presentation] 厚生労働省てんかん地域診療連携整備事業を実施していない施設：てんかんセンターとしての現状，シンポジウムてんかん地域診療連携整備事業の１年を振り返って． (2017)
  • Author(s): 松本理器，藤井大樹，本多正幸，小林勝哉，下竹昭寛，吉田健司，加藤竹雄，井内盛遠，人見健文，松橋眞生，菊池隆幸，吉田和道，國枝武治，岡田知久，村井俊哉，宮本享，髙橋良輔，池田昭夫
  • Organizer: 全国てんかんセンター協議会総会JEPICA
  • Place of Presentation: 奈良
  • Year and Date: 2017-02-18 – 2017-02-19
• [Presentation] Cortico-cortical Evoked Potentials -a practical review (2017)
  • Author(s): Ikeda A, Matsumoto R, Kobayashi K, Kunieda T
  • Organizer: Annual meeting of American Clinical Neurophysiology Society
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2017-02-08 – 2017-02-12
  • Int'l Joint Research / Invited
• [Presentation] Interictal slow shifts by macroinvasive electrodes, Consensus for recording and analysis of wide-band EEG in clinical epilepsy (2017)
  • Author(s): Ikeda A
  • Organizer: Annual meeting of American Clinical Neurophysiology Society
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2017-02-08 – 2017-02-12
  • Int'l Joint Research / Invited
• [Presentation] 皮質電気刺激によるヒト脳内ネットワークの可視化：着想から臨床応用への道のり（指名講演1） (2017)
  • Author(s): 松本理器
  • Organizer: 平成２８年度名古屋大学脳とこころの研究センターシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2017-02-01
• [Presentation] 臨床てんかん病態におけるグリア機能の臨床的意義． (2017)
  • Author(s): 池田昭夫
  • Organizer: 第40回日本てんかん外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2017-01-26 – 2017-01-27
• [Presentation] The ventral part of the anterior temporal lobe actively engages in Kanji word processing: a direct cortical stimulation study (2016)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Kobayashi K, Ota M, Sakamoto M, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph MA, Ikeda A
  • Organizer: 70th American Epilepsy Society Annual Meeting
  • Place of Presentation: Houston, USA
  • Year and Date: 2016-12-02 – 2016-12-06
  • Int'l Joint Research
• [Presentation] Clinical core symptoms are rather homogeneous in nationwide survey of benign adult familial myoclonus epilepsy (2016)
  • Author(s): Kobayashi K, Hitomi T, Matsumoto R, Watanabe M, Takahashi R, Ikeda A
  • Organizer: 70th American Epilepsy Society Annual Meeting
  • Place of Presentation: Houston, USA
  • Year and Date: 2016-12-02 – 2016-12-06
  • Int'l Joint Research
• [Presentation] Probing Dorsal and Ventral Language Networks by Integrated Invasive Neurophysiology (2016)
  • Author(s): Matsumoto R
  • Organizer: 11th International Workshop on Advances in Electrocorticography
  • Place of Presentation: Houston, USA
  • Year and Date: 2016-12-01
  • Int'l Joint Research / Invited
• [Presentation] Cortico-cortical evoked potentials: methods, its research and clinical perspectives (2016)
  • Author(s): Matsumoto R
  • Organizer: Seminar at Laboratory of Behavioral & Cognitive Neuroscience
  • Place of Presentation: Department of Neurology, Stanford University, USA
  • Year and Date: 2016-11-15
  • Invited
• [Presentation] Kanji word processing in the ventral anterior temporal lobe: a postoperative neuropsychological study in patients with temporal lobe epilepsy (2016)
  • Author(s): Ota M, Shimotake A, Matsumoto R, Sakamoto M, Daifu M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A
  • Organizer: Annual Meeting of Society for Neuroscience (Neuroscience 2016)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] EEG biomarker of epilepsy (2016)
  • Author(s): Ikeda A
  • Organizer: CAOA-AOEC Joint Symposium at the 10th AESC, 10th Asian Epilepsy Surgery Congress (AESC)
  • Place of Presentation: Songdo, Korea
  • Year and Date: 2016-11-05
  • Int'l Joint Research / Invited
• [Presentation] Intraoperative, higher cortical function monitoring (2016)
  • Author(s): Ikeda A, Matsumoto R, Kunieda T, Yamao Y, Kikuchi T
  • Organizer: Intraoperative neuromonitoring (IONM) Satellite Symposium, 2016 Annual Meeting of Korean Neurological Association
  • Place of Presentation: Seoul
  • Year and Date: 2016-11-04 – 2016-11-05
  • Int'l Joint Research / Invited
• [Presentation] Glia, DC shifts/red slow, and epilepsy (2016)
  • Author(s): Ikeda A
  • Organizer: 2016 Annual Meeting of Korean Neurological Association
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-11-04 – 2016-11-05
  • Int'l Joint Research / Invited
• [Presentation] Repeated, cortical stimulation can modify the wideband cortical activity correlates of interictal epileptiform discharge. (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kunieda T, Miyamoto S, Hattori N, Takahashi R, Ikeda A
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Year and Date: 2016-10-27 – 2016-10-29
• [Presentation] Functional brain mapping of primary sensorimotor cortex by means of MRCP and ERS/ERD comparing with CSM. (2016)
  • Author(s): Neshige S, Sakurai T, Kobayashi K, Shimotake A, Matsuhashi M, Matsumoto R, Hitomi T, Matsumoto M, Takahashi R, Ikeda A
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Year and Date: 2016-10-27 – 2016-10-29
• [Presentation] 聴覚刺激のピッチ変化方向の異同は前意識下で検出されている． (2016)
  • Author(s): 齊藤景子，松橋眞生，粟屋智就，加藤竹雄，美馬達哉，池田昭夫，福山秀直，平家俊男
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Year and Date: 2016-10-27 – 2016-10-29
• [Presentation] 日本語読みにおける側頭葉底面の前後方向の機能の相違：高頻度皮質刺激による研究 (2016)
  • Author(s): 大封昌子，松本理器，下竹昭寛，太田真紀子，坂本光弘，中江卓郎，小林勝哉，菊池隆幸，吉田和道，國枝武治，髙橋良輔，Lambon Ralph MA，池田昭夫
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Year and Date: 2016-10-27 – 2016-10-29
• [Presentation] 頭痛診療医に必要なてんかんの知識と鑑別診断：症例を通じて（てんかんと片頭痛の興奮性の違いは？）（ランチョンセミナー3） (2016)
  • Author(s): 池田昭夫
  • Organizer: 第44回日本頭痛学会総会
  • Place of Presentation: 京都
  • Year and Date: 2016-10-21 – 2016-10-22
• [Presentation] When should patients be referred to psychiatrists?: The ILAE Neuropsychiatry Commission Symposium “Depression in patients with epilepsy: how could neurologists, psychiatrists and neurosurgeons co-work and how much do Asian colleagues acknowledge it? (2016)
  • Author(s): Matsumoto R
  • Organizer: The ILAE Neuropsychiatry Commission Symposium
  • Place of Presentation: Nagakute
  • Year and Date: 2016-10-09
  • Int'l Joint Research / Invited
• [Presentation] 認知症とてんかん（アドバンスドコース11） (2016)
  • Author(s): 松本理器
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 臨床てんかん学におけるwide-band EEGの概要と有用性 (2016)
  • Author(s): 池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] JESスカラーシップ、Sponsored awardの意義（企画セッション10 てんかん学研修システムを考える）． (2016)
  • Author(s): 池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] ミオクローヌスを有するてんかん症候群とJME． (2016)
  • Author(s): 小林勝哉，人見健文，松本理器，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 単発電気刺激による脳内ネットワークの可視化：着想から臨床応用への道のり（特別企画4 機能ネットワーク解明から治療への応用）． (2016)
  • Author(s): 松本理器，山尾幸広，菊池隆幸，吉田和道，國枝武治
  • Organizer: 第75回日本脳神経外科学会学術総会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] Repeated, cortical stimulation inhibits cortical epileptic excitability in human epileptic focus. (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N, Ikeda A
  • Organizer: 第50回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] The clinical features of elderly onset, temporal lobe epilepsy. (2016)
  • Author(s): Takeyama H, Matsumoto R, Sakamoto M, Togawa J, Kanazawa K, Kobayashi K, Shimotake A, Hitomi T, Takahashi Y, Watanabe O, Takahashi R, Ikeda A
  • Organizer: 第50回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] Invasive 3D source localization by wide-band EEG finding. (2016)
  • Author(s): Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda, T, Matsumoto R, Takahashi R, Ikeda A
  • Organizer: 第50回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] Comparison in afterslow activity of epileptiform discharges and sharp transients among different time constant. (2016)
  • Author(s): Sultana S, Hitomi T, Daifu M, Matsuhashi M, Takahashi R, Ikeda A
  • Organizer: 第50回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] てんかん病診連携システムを介して大学病院を受診した患者のサンプル調査． (2016)
  • Author(s): 谷岡洸介，佐藤和明，音成秀一郎，塚田剛史，藤井大樹，井上岳司，吉村元，小林勝哉，下竹昭寛，人見健文，松本理器，高橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 呼称課題を用いた低刺激強度皮質電気刺激の言語機能マッピングの有用性． (2016)
  • Author(s): 下竹昭寛，松本理器，坂本光弘，中谷光良，太田真紀子，小林勝哉，菊池隆幸，吉田和道，國枝武治，宮本享，髙橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 自己免疫性てんかんの診断における、診療症状・検査所見の有用性の検討． (2016)
  • Author(s): 坂本光弘，松本理器，十川純平，武山博文，端祐一郎，小林勝哉，下竹昭寛，近藤誉之，高橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 発作間欠期皮質脳波における徐波と高周波律動の共起：自動検出のための解析方法についての検討． (2016)
  • Author(s): 大封昌子，井内盛遠，松橋眞生，金澤恭子，小林勝哉，下竹昭寛，人見健文，菊池隆幸，吉田和道，國枝武治，松本理器，髙橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 側頭葉底面前方領域切除による意味記憶の変容と機能可塑性の解明． (2016)
  • Author(s): 太田真紀子，松本理器，下竹昭寛，坂本光弘，大封昌子，中江卓郎，菊池隆幸，吉田和道，國枝武治，宮本享，髙橋良輔，Lambon Ralph MA，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 日本てんかん学会の教育研究事業としての助成金の成果の検討． (2016)
  • Author(s): 谷岡洸介，渡辺雅子，池田昭夫，兼子直，田中達也，大澤真木子
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] 意識が保持され，全身けいれん発作が群発するMRI陰性症例 (2016)
  • Author(s): 音成秀一郎，松本理器，小林勝哉，下竹昭寛，人見健文，井内盛遠，丸山博文，高橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] アセタゾラミドが著効する難治性てんかん患者の臨床的特徴の検討． (2016)
  • Author(s): 藤井大樹，谷岡洸介、佐藤啓、井上岳司、村原貴史、小林勝哉、下竹昭寛、松本理器、高橋良輔、池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] Ictal deafnessを認めた３症例 (2016)
  • Author(s): 本多正幸, 小林勝哉, 下竹昭寛, 松本理器, 加藤竹雄, 高橋良輔, 池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07 – 2016-10-09
• [Presentation] Probing dynamics of cortico-cortical connectivity with direct cortical stimulation in physiological and pathologic states (2016)
  • Author(s): Matsumoto R
  • Organizer: Symposium: Network disruption in brain disorders, Biomag 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-10-03
  • Int'l Joint Research / Invited
• [Presentation] 左中心前回中・下部に限局した腫瘍切除後にanarthriaを呈した1例． (2016)
  • Author(s): 坂本光弘，松本理器，下竹昭寛，太田真紀子，中谷光良，菊池隆幸，吉田和道，國枝武治，池田昭夫
  • Organizer: 第40回日本神経心理学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2016-09-15 – 2016-09-16
• [Presentation] てんかん原性の臨床生理学的biomaker:red slowはあるか？ (2016)
  • Author(s): 池田昭夫
  • Organizer: 第12回日本てんかん学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-23
• [Presentation] 食事中の大きな笑いにより強直発作様の意識消失を呈した73歳男性例． (2016)
  • Author(s): 本多正幸，下竹昭寛，坂戸勇介，引網亮太，藤井大樹，小林勝哉，松本理器，池田昭夫，髙橋良輔
  • Organizer: 第12回日本てんかん学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-23
• [Presentation] Ventral part of the anterior temporal lobe actively engages in Kanji reading: Evidence from direct cortical stimulation of the basal temporal language area. (2016)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Sakamoto M, Ota M, Kunieda T, Miyamoto S, Takahashi R, Lambon Ralph MA, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Functional mapping of praxis: Electrical cortical stimulation study. (2016)
  • Author(s): Shimotake A, Matsumoto R, Kobayashi K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Human motor inhibition network as revealed by epicortical ERP, CCEP and high frequency cortical stimulation. (2016)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Antero-posterior gradients exist in functional connections between human inferior frontal gyrus and middle and posterior temporal gyri: An intraoperative cortico-cortical evoked potential study (2016)
  • Author(s): Nakae T, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi T, Inada T, Takahashi Y, Nishida S, Inano R, Kobayashi K, Shimotake A, Matsuhashi M, Kikuchi T, Takahashi R, Ikeda A, Miyamoto S
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Functional connectivity from medial parietal cortex and superior parietal lobule: a cortico-cortical evoked potential study. (2016)
  • Author(s): Togo M, Matsumoto R, Takeyama H, Kobayashi K, Shimotake A, Usami K, Inouchi M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Compensatory mechanisms of semantic- and kanji / kana word processing after resection of the anterior temporal lobe (in epilepsy surgery). (2016)
  • Author(s): Ota M, Shimotake A, Matsumoto R, Sakamoto M, Daifu M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Expressional analysis of astrocytic Kir4.1 channels in audiogenic seizure-susceptible Lgi1L385R/+ mutant rats. (2016)
  • Author(s): Kinboshi M, Mukai T, Tokudome K, Kunisawa N, Higor A. Iha, Shimizu S, Serikawa T, Ito H, Ikeda A, Ohno Y
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Phase angle has information on temporal relationship of signals in functional connectivity study in human brain magnetoencephalography analysis. (2016)
  • Author(s): Yoshinaga K, Matsuhashi M, Hanakawa T, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Repeated, cortical stimulation inhibits epileptic excitability in human epileptic focus. (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kunieda T, Miyamoto S, Hattori N, Takahashi R, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] Updates of Neurophysiological Biomarkers in the Genetic Generalized Epilepsy (symposium The 9th KES-JES Joint Symposium) (2016)
  • Author(s): Hitomi T, Kobayashi K, Takahashi R, Ikeda A
  • Organizer: 21st Korean Epilepsy Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-17 – 2016-06-18
  • Int'l Joint Research / Invited
• [Presentation] Hands-on 3「脳波」 (2016)
  • Author(s): 池田昭夫
  • Organizer: 日本神経学会学術大会第13回生涯教育セミナー
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-21
• [Presentation] Uncommon, but important causes of epilepsy and seizure. (2016)
  • Author(s): 池田昭夫
  • Organizer: 第57回日本神経学会学術大会（International Educational Session 03 How to Manage Seizures）
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 自己免疫性てんかんとの関連． (2016)
  • Author(s): 松本理器
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 非けいれん性てんかん重積（NSCE）：診断と治療． (2016)
  • Author(s): 松本理器
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 成人てんかんとオシロロジー（シンポジウム15 オシロロジーからみた神経疾患の病態と治療）． (2016)
  • Author(s): 池田昭夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 高齢者てんかん重積状態の臨床的特徴と治療（シンポジウム 治るてんかん：高齢者てんかんの診断と治療） (2016)
  • Author(s): 吉村元，松本理器，池田昭夫，幸原伸夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] Which areas inhibit motor responses? Direct evidence from subdural recordings. (2016)
  • Author(s): Takeyama H, Matsumoto M, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] Enhancement of coupling between slow waves and high gamma activities during slow wave sleep in human. (2016)
  • Author(s): Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] Surrogate marker of intracranially recorded ictal DC shifts and HFOs in human focal epilepsy. (2016)
  • Author(s): Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] Wide-band Electrocorticographic (ECoG) data analysis in primary sensorimotor (SI-MI) area (2016)
  • Author(s): Neshige S, Sakurai T, Kobayashi K, Shimotake A, Matsuhashi M, Matsumoto R, Hitomi T, Matsumoto M, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 自己免疫機序が関与するてんかん症候群の診断アルゴリズム構築の試み． (2016)
  • Author(s): 坂本光弘，松本理器，十川純平，武山博文，端祐一郎，小林勝哉，下竹昭寛，近藤誉之，髙橋良輔，池田昭夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] BAFMEにおけるPET画像上の特徴． (2016)
  • Author(s): 村井智彦，人見健文，小林勝哉，下竹昭寛，岡田知久，松本理器，富樫かおり，澤本伸克，髙橋良輔，池田昭夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 脳波判読セミナーのアンケート調査からの脳波教育の現状解析；過去5年間の実態とニーズ． (2016)
  • Author(s): 谷岡洸介，人見健文，松本理器，飛松省三，犬塚貴，吉良潤一，楠進，髙橋良輔，池田昭夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 良性成人型家族性ミオクローヌスてんかんにおけるてんかん性放電の睡眠による変容． (2016)
  • Author(s): 人見健文，小林勝哉，井内盛遠，櫻井健世，Shamima Sultana，佐藤啓，井上岳司，下竹昭寛，松本理器，陳和夫，髙橋良輔，池田昭夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 低酸素脳症の頭皮上脳波における脳波所見と超低周波活動（infraslow activity）の検討． (2016)
  • Author(s): 十河正弥，人見健文，村井智彦，松橋眞生，松本理器，幸原伸夫，髙橋良輔，池田昭夫
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 自己免疫性てんかんにおける末梢血リンパ球の表面抗原解析． (2016)
  • Author(s): 端祐一郎，坂本光弘，十川純平，岡田洋一郎，藤井ちひろ，越智博文，中川正法，水野敏樹，下竹昭寛，松本理器，漆谷真，池田昭夫，髙橋良輔，近藤誉之
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 脊髄サルコイドーシスの治療に関する臨床的検討． (2016)
  • Author(s): 三橋賢大，北村彰浩，小林勝哉，上村紀仁，葛谷聡，山下博文，澤本伸克，近藤誉之，漆谷真，池田昭夫，髙橋良輔
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] 再発性多発軟骨炎に伴う脳炎2症例の検討， (2016)
  • Author(s): 岡田信久，和田隆史，樽野陽亮，眞木崇州，吉藤元，丹治正大，三橋賢大，山門穂高，上田紗希帆，前川嵩太，引網亮太，木下久徳，綾木孝，山下博文，澤本伸克，漆谷真，池田昭夫，髙橋良輔
  • Organizer: 第57回日本神経学会学術大会．
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] HFO synchronization and epilepsy network (2016)
  • Author(s): Ikeda A
  • Organizer: 11th Asian and Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2016-05-13 – 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] Exploring the mysteries of EEG: Can infraslow and DC shift improve epilepsy treatment? (2016)
  • Author(s): Ikeda A
  • Organizer: The Masakazu Seino Memorial Lecture, 11th Asian & Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2016-05-13 – 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] Advanced techniques in HFO analysis. Workshop HFOs and the Epileptogenic Zone (2016)
  • Author(s): Ikeda A
  • Organizer: 11th Asian & Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hongkong, China
  • Year and Date: 2016-05-13 – 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] Functional mapping of praxis network: Electrical cortical stimulation study. (2016)
  • Author(s): Shimotake A, Matsumoto R, Togo M, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08 – 2016-05-09
  • Int'l Joint Research
• [Presentation] Role of left ventral precentral gyrus in apraxia of speech: documents with electrical cortical stimulation and focal resection. (2016)
  • Author(s): Sakamoto M, Matsumoto R, Shimotake A, Nakae T, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08 – 2016-05-09
  • Int'l Joint Research
• [Presentation] Functional connectivity from human superior pariental lobule and medial pariental lobe: a cortico-cortical evoked potential (CCEP) study. (2016)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Inouchi M, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08 – 2016-05-09
  • Int'l Joint Research
• [Presentation] 認知症鑑別診断への脳波利用の試み， (2016)
  • Author(s): 佐藤啓，人見健文，葛谷聡，武地一，木下彩栄，池田昭夫，髙橋良輔
  • Organizer: 第113回日本内科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-15 – 2016-04-17
• [Book] 臨床神経生理 (2016)
  • Author(s): 十川純平，松本理器
  • Total Pages: 62-65（225）
  • Publisher: 中外医学社
• [Book] 臨床神経生理 (2016)
  • Author(s): 大封昌子，松本理器
  • Total Pages: 66-68（225）
  • Publisher: 中外医学社
• [Book] 臨床神経生理 (2016)
  • Author(s): 井上岳司，池田昭夫
  • Total Pages: 75-78（225）
  • Publisher: 中外医学社
• [Book] 臨床神経生理 (2016)
  • Author(s): 下竹昭寛，池田昭夫
  • Total Pages: 34-36（225）
  • Publisher: 中外医学社
• [Book] 不随意運動の診断と治療（改訂第2版） (2016)
  • Author(s): 人見健文，寺田清人，池田昭夫
  • Total Pages: 158-182（308）
  • Publisher: 診断と治療社
• [Book] 内科診療実践マニュアル第２版 (2016)
  • Author(s): 塚田剛史，井上岳司，池田昭夫
  • Total Pages: 538-547（706）
  • Publisher: 日本医学出版
• [Book] 内科診療実践マニュアル第２版 (2016)
  • Author(s): 藤井大樹，池田昭夫
  • Total Pages: 26-29（706）
  • Publisher: 日本医学出版
• [Book] JMEDJ治療法便覧2016 -私の治療- (2016)
  • Author(s): 吉村元，池田昭夫
  • Total Pages: 1（１）
  • Publisher: 日本医事新報社
• [Book] てんかん白書 (2016)
  • Author(s): 池田昭夫，田中達也
  • Total Pages: 177-179 （197）
  • Publisher: 南江堂
• [Book] てんかん白書 (2016)
  • Author(s): 池田昭夫
  • Total Pages: 119-121（197）
  • Publisher: 南江堂
• [Book] 日本てんかん学会50周年記念誌 (2016)
  • Author(s): 田中達也，池田昭夫
  • Total Pages: 33-34（99）
  • Publisher: 診断と治療社
• [Book] 日本てんかん学会50周年記念誌 (2016)
  • Author(s): 加藤元博，池田昭夫
  • Total Pages: 43-44（99）
  • Publisher: 診断と治療社
• [Remarks] てんかん・運動異常生理学講座 京都大学 -> 業績
  • URL: http://epilepsy.med.kyoto-u.ac.jp/results
• [Remarks] 京都大学大学院医学研究科脳病態生理学講座臨床神経学（神経内科）-> 研究紹介 -> 神経生理学
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/laboratory/lab_3_5.htm