Understanding human diseases from the viewpoint of lipoquality

2019 Fiscal Year Final Research Report

• Project Area: Quality of lipids in biological systems
• Project/Area Number: 15H05906
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: Yatomi Yutaka 東京大学, 医学部附属病院, 教授 (60200523)
• Co-Investigator(Kenkyū-buntansha): 本田 哲也 京都大学, 医学研究科, 講師 (40452338)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: リポクオリティ / ヒト臨床サンプル / 動脈硬化性疾患 / 癌 / 神経障害性疼痛 / 皮膚疾患

Outline of Final Research Achievements

We have elucidated the importance of "Lipoquality" in the pathogenesis of human disaseses, especially atherosclerosis, cancer, neuropathic pain, and skin diseases, by integrated approach of clinical studies and basic study. We measured and analyzed lipids and their related proteins using human samples such as blood, cerebrospinal fluid, urine, and surgical specimen and based on the results from these clinical studies, we performed basic experiments using animals and cells to elucidate the underlying mechanisms and possible therapeutic application. From this research, we have shown that the field of "Lipoquality" could develop through further translational researches in the future.

Free Research Field

臨床検査医学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、基礎研究から提唱されていたリポクオリティの重要性が実際のヒト疾患にもあてはまる可能性を提唱できたことである。特に、未だ治療法・予防法が十分でない、動脈硬化性疾患、癌、神経障害性疼痛、アレルギー・乾癬といった皮膚疾患において、リポクオリティの重要性を発見することができたことは意義深い。このことから、将来のトランスレーショナルリサーチを通じて、リポクオリティの臨床検査および疾患治療・予防法の確立へとつながることが期待できる。