大規模シーケンスとコンピューティングによるがんの進化と多様性の解明

2016 Fiscal Year Annual Research Report

• Project Area: Conquering cancer through neo-dimensional systems understanding
• Project/Area Number: 15H05909
• Research Institution: Kyoto University
• Principal Investigator: 小川 誠司 京都大学, 医学研究科, 教授 (60292900)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: 総合生物 / ゲノム科学 / システムゲノム科学 / 腫瘍学

Outline of Annual Research Achievements

a)癌の起源と進化に関する解析。骨髄異形成症候群について、2500例を超えるMDSの遺伝子変異について、MDSの病期に集積する特徴的な変異を明らかにするとともに、100例を超える経時的な試料の解析によりそれらの病期進行における意義を明らかにした(牧島ら、Nature Genetics, 2017他)。また、大腸および尿管上皮の前がん病変の解析から、大腸がん、腎盂尿管がんの初期病変に関わる遺伝子変異と、これらの変異を生じたクローンが拡大する様式を明らかにした。
b)全ゲノムシーケンスによる新たな発がんメカニズムの解析については、成人T細胞白血病(ATL)の全ゲノムシーケンスの解析により、ATLの約25%の症例で、免疫チェックポイントの一つである PD-L1遺伝子の3’非翻訳領域(3’-UTR)に様々な構造異常が生じ、PD-L1の著しい発現上昇が惹起されることが明らかとなった。さらに、京コンピュータ等を駆使した10000例を超えるがんのRNAシーケンスデータの解析から、同様の異常が様々な癌腫で認められたことから、PD-L1の構造異常を介した免疫回避がヒトのがんで重要な役割を担っていることが示唆された(片岡ら、Nature, 2016)。また、これらの異常を有する腫瘍は、ニボルマブを初めとする抗PD-1抗体が有効である可能性が示唆された。
c)胚細胞系列の変異に関する解析については、DDX41遺伝子のマウスモデルの解析を進めるとともに、日本バイオバンクの1万例を超える健常試料に関する標的シーケンスを行った。
d)臨床シーケンスについては、日本骨髄バンクを通じて非血縁移植が行われたMDS症例約800例について、骨髄系腫瘍で高頻度に変異する遺伝子に関する網羅的な標的シーケンスを行い、遺伝子変異が移植成績に及ぼす効果を明らかにした(吉里ら、Blood, 2017)。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

ATLの全ゲノムシーケンス解析では、がんの免疫回避に関わる主要分子であるPD-L1の3’UTRを含む構造異常がATLを初めとする様々なヒトのがんで認められ、がんの免疫回避に関わっていること、またPD-L1の3’UTRが同遺伝子の発現調節に重要な役割を担っていることを世界で初めて明らかにした。本研究成果は、2016年、Nature紙に掲載され(片岡ら、Nature, 2016)、抗腫瘍免疫に関わる顕著な発見として国際的に極めて高く評価されており、文部科学大臣表彰の栄に浴することができた。
一方、骨髄異形成症候群(MDS)の発症と進展に関わる研究においては、2500例のMDSにおける遺伝子変異に関する検討から、MDSの病期の進展と遺伝子変異の関係に関する網羅的な検討を行うとともに、経時的に採取されたMDS試料の全エクソン・標的シーケンスを行うことにより、MDSの病期の進展・クローン進化に関わる遺伝子変異とその意義を明らかにした。本研究は、Nature genetics紙およびNature communication紙に掲載され、MDSの病態解明のみならず、MDSの予後予測や治療判断の決定における臨床シーケンスの有用性を示す研究成果として高く評価されている(牧島ら、Nature genetics, 2017および、de Silva-Coelho et al., Nature comm, 2016)。さらに、日本骨髄バンクにおける800例を超える移植症例の遺伝子変異の解析から、MDSの造血幹細胞移植における遺伝子変異の効果の検討について明らかにし (吉里ら、Blood, 2017)、MDSの研究分野で高い評価を受けている。
その他、大腸がん、食道がんその他の解析についても、大旨予定どおりに進行しており、また以上の成果に鑑みて、研究は当初の予定以上の研究成果が得られていると判断した。

Strategy for Future Research Activity

1)癌の起源と進化に関する解析では、食道癌、大腸がん、甲状腺癌および泌尿器系腫瘍について、前がん病変、健常組織を含めた多数サンプリングによるシーケンス解析をさらに進めることにより、これらのがんの発症とクローン進化の過程をその初期病変から解明することを試みる。
2)全ゲノムシーケンスによる新たな発がんメカニズムの解析。びまん性大細胞型リンパ腫、中枢神経リンパ腫、末梢T細胞性リンパ腫、およびMDSについて腫瘍および正常組織(頬粘膜ないしCD3陽性細胞)についも、各48ペアについて全ゲノムシーケンス解析を行い、宮野らによる新規アルゴリズムを用いて単一塩基置換、塩基の挿入欠失、tandem duplication、遺伝子再構成を高精度に同定する。また、non-coding RNAの発現異常や構造異常に関わるゲノム変異を同定し、同定されたnon-coding RNAについては、癌化における意義について機能的な解析を行う。
3)胚細胞系列の変異に関する解析。家族性MDSの家系について全エクソンないし全ゲノムシーケンスを行い、MDSの発症に関わる胚細胞変異の同定を試みる。DDX41遺伝子変異については前年度までに作成した機能欠失アレルおよびR525Hアレルを導入したマウスモデルにおける経時的採血によって得られる試料のシーケンス解析を用いたMDSのクローン進化の検討を行う。Biobabk Japanの試料を用いた次世代シーケンス解析により、骨髄系腫瘍におけるドライバー遺伝子の胚細胞変異の網羅的な探索を行う。
4)臨床シーケンスに関する検討。大腸癌検体1000例および甲状腺乳頭癌500例について既知のドライバー変異に関するターゲットシーケンスを行い、遠隔転移や予後と相関する分子マーカーの同定を行う。

Research Products

• [Journal Article] ynamics of clonal evolution in myelodysplastic syndromes. (2017)
  • Author(s): Makishima H, et al.
  • Journal Title: Nat Genet. Volume: 49 Pages: 204-212
  • DOI: 10.1038/ng.3742
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Recurrent genetic defects on chromosome 5q in myeloid neoplasms. (2017)
  • Author(s): Hosono N, Makishima H, Mahfouz R, Przychodzen B, Yoshida K, Jerez A, LaFramboise T, Polprasert C, Clemente MJ, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Sanada M, Cui E, Verma AK, McDevitt MA, List AF, Saunthararajah Y, Sekeres MA, Boultwood J, Ogawa S, Maciejewski JP.
  • Journal Title: Oncotarget. Volume: 8 Pages: 6483-6495
  • DOI: 10.18632/oncotarget.14130
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities. (2017)
  • Author(s): Yoshida M, Hamanoue S, Seki M, Tanaka M, Yoshida K, Goto H, Ogawa S, Takita J, Tanaka Y.
  • Journal Title: Hum Pathol. Volume: - Pages: -
  • DOI: 10.1016/j.humpath.2016.06.024.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ASXL2 Mutations are Frequently Found in Pediatric AML Patients with t(8;21)/RUNX1-RUNX1T1 and Associated with a Better Prognosis. (2017)
  • Author(s): Yamato G, Shiba N, Yoshida K, Shiraishi Y, Hara Y, Ohki K, Okubo J, Okuno H, Chiba K, Tanaka H, Kinoshita A, Moritake H, Kiyokawa N, Tomizawa D, Park MJ, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Genes Chromosomes Cancer. Volume: - Pages: -
  • DOI: 10.1002/gcc.22443.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome. (2017)
  • Author(s): Takagi M, Ogata S, Ueno H, Yoshida K, Yeh T, Hoshino A, Piao J, Yamashita M, Nanya M, Okano T, Kajiwara M, Kanegane H, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Bando Y, Kato M, Hayashi Y, Miyano S, Imai K, Ogawa S, Kojima S, Morio T.
  • Journal Title: J Allergy Clin Immunol. Volume: - Pages: -
  • DOI: 10.1016/j.jaci.2016.09.038.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BRCA1 Alterations with Additional Defects in DNA Damage Response Genes May Confer Chemoresistance to BRCA-like Breast Cancers Treated with Neoadjuvant Chemotherapy. (2017)
  • Author(s): Takada M, Nagai S, Haruta M, Sugino RP, Tozuka K, Takei H, Ohkubo F, Inoue K, Kurosumi M, Miyazaki M, Sato-Otsubo A, Sato Y, Ogawa S, Kaneko Y.
  • Journal Title: Genes Chromosomes Cancer. Volume: - Pages: -
  • DOI: 10.1002/gcc.22445
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). (2017)
  • Author(s): Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, Lill M, Hayashi M, Kinoshita A, Kantarjian HM, Kornblau SM, Ogawa S, Haferlach T, Yang H, Koeffler HP.
  • Journal Title: Leukemia. Volume: 31 Pages: 1-10
  • DOI: 10.1038/leu.2016.160.
  • Int'l Joint Research
• [Journal Article] Partial monosomy of 10p and duplication of another chromosome in two patients. (2017)
  • Author(s): Ohta S, Isojima T, Mizuno Y, Kato M, Mimaki M, Seki M, Sato Y, Ogawa S, Takita J, Kitanaka S, Oka A.
  • Journal Title: Pediatr Int. Volume: 59 Pages: 99-102
  • DOI: 10.1111/ped.13181.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma. (2017)
  • Author(s): Nishizawa S, Sakata-Yanagimoto M, Hattori K, Muto H, Nguyen T, Izutsu K, Yoshida K, Ogawa S, Nakamura N, Chiba S.
  • Journal Title: Int J Hematol. Volume: - Pages: -
  • DOI: 10.1007/s12185-016-2159-z.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene. (2017)
  • Author(s): Nadeau SA, An W, Mohapatra BC, Mushtaq I, Bielecki TA, Luan H, Zutshi N, Ahmad G, Storck MD, Sanada M, Ogawa S, Band V, Band H.
  • Journal Title: J Biol Chem. Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes. (2017)
  • Author(s): Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E, Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S.
  • Journal Title: Genet Med. Volume: - Pages: -
  • DOI: 10.1038/gim.2016.197.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia. (2017)
  • Author(s): Ikeda F, Yoshida K, Toki T, Uechi T, Ishida S, Nakajima Y, Sasahara Y, Okuno Y, Kanezaki R, Terui K, Kamio T, Kobayashi A, Fujita T, Sato-Otsubo A, Shiraishi Y, Tanaka H, Chiba K, Muramatsu H, Kanno H, Ohga S, Ohara A, Kojima S, Kenmochi N, Miyano S, Ogawa S, Ito E.
  • Journal Title: Haematologica. Volume: - Pages: -
  • DOI: 10.3324/haematol.2016.153932.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing. (2017)
  • Author(s): Ichimura T, Yoshida K, Okuno Y, Yujiri T, Nagai K, Nishi M, Shiraishi Y, Ueno H, Toki T, Chiba K, Tanaka H, Muramatsu H, Hara T, Kanno H, Kojima S, Miyano S, Ito E, Ogawa S, Ohga S.
  • Journal Title: Int J Hematol. Volume: - Pages: -
  • DOI: 10.3324/haematol.2016.153932.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations. (2017)
  • Author(s): Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Ueno H, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Kobayashi M, Nakamura H, Kamizono J, Mitsui-Sekinaka K, Ichimura T, Ohga S, Nakazawa Y, Takagi M, Imai K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H.
  • Journal Title: J Allergy Clin Immunol. Volume: - Pages: -
  • DOI: 10.1016/j.jaci.2016.09.029.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia. (2017)
  • Author(s): Ding LW, Sun QY, Tan KT, Chien W, Thippeswamy AM, Eng Juh Yeoh A, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernandez LT, Preethi H, Lill M, Kantarjian HM, Kornblau SM, Miyano S, Liang DC, Ogawa S, Shih LY, Yang H, Koeffler HP.
  • Journal Title: Cancer Res. Volume: 77 Pages: 390-400
  • DOI: 10.1016/j.jaci.2016.09.029.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD. (2017)
  • Author(s): Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K, Stocking C, Lill M, Madan V, Hattori N, Gery S, Ogawa S, Wakita S, Ikezoe T, Shih LY, Alpermann T, Haferlach T, Yang H, Koeffler HP.
  • Journal Title: Leukemia. Volume: - Pages: -
  • DOI: 10.1038/leu.2016.343.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype. (2016)
  • Author(s): Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M.
  • Journal Title: Br J Haematol. Volume: 175 Pages: 457-461
  • DOI: 10.1111/bjh.14243.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Array CGH identifies copy number changes in 11% of 520 MDS patients with normal karyotype and uncovers prognostically relevant deletions. (2016)
  • Author(s): Volkert S, Haferlach T, Holzwarth J, Zenger M, Kern W, Staller M, Nagata Y, Yoshida K, Ogawa S, Schnittger S, Haferlach C.
  • Journal Title: Leukemia. Volume: 30 Pages: 259-261
  • DOI: 10.1038/leu.2015.257.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution (2016)
  • Author(s): Uchi R, et al.
  • Journal Title: PLoS Genet. Volume: 12 Pages: e1005778
  • DOI: 10.1371/journal.pgen.1005778
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome-like immunodeficiency. (2016)
  • Author(s): Tsujita Y, et al.
  • Journal Title: J Allergy Clin Immunol. Volume: 138 Pages: 1672-1680 e1610
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Paroxysmal nocturnal hemoglobinuria induced by the occurrence of BCR-ABL in a PIGA mutant hematopoietic progenitor cell. (2016)
  • Author(s): Tominaga R, Katagiri T, Kataoka K, Kataoka K, Wee RK, Maeda A, Gomyo H, Mizuno I, Murayama T, Ogawa S, Nakao S.
  • Journal Title: Leukemia. Volume: 30 Pages: 1208-1210
  • DOI: 10.1038/leu.2015.268.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia. (2016)
  • Author(s): Shiba N, Yoshida K, Shiraishi Y, Okuno Y, Yamato G, Hara Y, Nagata Y, Chiba K, Tanaka H, Terui K, Kato M, Park MJ, Ohki K, Shimada A, Takita J, Tomizawa D, Kudo K, Arakawa H, Adachi S, Taga T, Tawa A, Ito E, Horibe K, Sanada M, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Br J Haematol. Volume: 175 Pages: 476-489
  • DOI: 10.1111/bjh.14247.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] International cancer seminars: a focus on kidney cancer. (2016)
  • Author(s): Scelo G, et al.
  • Journal Title: Ann Oncol. Volume: 27 Pages: 1382-1385
  • DOI: 10.1093/annonc/mdw186.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016)
  • Author(s): Sawada G, et al.
  • Journal Title: Gastroenterology. Volume: 150 Pages: 1171-1182
  • DOI: 10.1053/j.gastro.2016.01.035.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele. (2016)
  • Author(s): Sakurai M, Kasahara H, Yoshida K, Yoshimi A, Kunimoto H, Watanabe N, Shiraishi Y, Chiba K, Tanaka H, Harada Y, Harada H, Kawakita T, Kurokawa M, Miyano S, Takahashi S, Ogawa S, Okamoto S, Nakajima H.
  • Journal Title: Blood Cancer J. Volume: 6 Pages: e392
  • DOI: 10.1038/bcj.2015.81.
  • Peer Reviewed / Open Access
• [Journal Article] Impact of SNP array karyotyping on the diagnosis and the outcome of chronic myelomonocytic leukemia with low risk cytogenetic features or no metaphases. (2016)
  • Author(s): Palomo L, Xicoy B, Garcia O, Mallo M, Adema V, Cabezon M, Arnan M, Pomares H, Jose Larrayoz M, Jose Calasanz M, Maciejewski JP, Huang D, Shih LY, Ogawa S, Cervera J, Such E, Coll R, Grau J, Sole F, Zamora L.
  • Journal Title: Am J Hematol. Volume: 91 Pages: 185-192
  • Peer Reviewed / Open Access
• [Journal Article] Clonal hematopoiesis in acquired aplastic anemia. (2016)
  • Author(s): Ogawa S.
  • Journal Title: Blood. Volume: 128 Pages: 337-347
  • DOI: 10.1182/blood-2016-01-636381.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis. (2016)
  • Author(s): Niemoller C, Renz N, Bleul S, Blagitko-Dorfs N, Greil C, Yoshida K, Pfeifer D, Follo M, Duyster J, Claus R, Ogawa S, Lubbert M, Becker H.
  • Journal Title: Leuk Res. Volume: 47 Pages: 41-46
  • DOI: 10.1016/j.leukres.2016.05.008.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma. (2016)
  • Author(s): Nagata Y, et al.
  • Journal Title: Blood Volume: 127 Pages: 596-604
  • DOI: 10.1016/j.leukres.2016.05.008.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adults with germline CBL mutation complicated with juvenile myelomonocytic leukemia at infancy. (2016)
  • Author(s): Muraoka M, Okuma C, Kanamitsu K, Ishida H, Kanazawa Y, Washio K, Seki M, Kato M, Takita J, Sato Y, Ogawa S, Tsukahara H, Oda M, Shimada A.
  • Journal Title: J Hum Genet. Volume: 61 Pages: 523-526
  • DOI: 10.1038/jhg.2016.8.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation. (2016)
  • Author(s): Morishima S, Kashiwase K, Matsuo K, Azuma F, Yabe T, Sato-Otsubo A, Ogawa S, Shiina T, Satake M, Saji H, Kato S, Kodera Y, Sasazuki T, Morishima Y, Japan Marrow Donor P.
  • Journal Title: Haematologica. Volume: 101 Pages: 491-498
  • DOI: 10.3324/haematol.2015.136903.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms. (2016)
  • Author(s): Mori T, Nagata Y, Makishima H, Sanada M, Shiozawa Y, Kon A, Yoshizato T, Sato-Otsubo A, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Ishiyama K, Miyawaki S, Mori H, Nakamaki T, Kihara R, Kiyoi H, Koeffler HP, Shih LY, Miyano S, Naoe T, Haferlach C, Kern W, Haferlach T, Ogawa S, Yoshida K.
  • Journal Title: Leukemia. Volume: 30 Pages: 2270-2273
  • DOI: 10.1038/leu.2016.212.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Somatic mosaicism in chronic myeloid leukemia in remission. (2016)
  • Author(s): Mitani K, Nagata Y, Sasaki K, Yoshida K, Chiba K, Tanaka H, Shiraishi Y, Miyano S, Makishima H, Nakamura Y, Nakamura Y, Ichikawa M, Ogawa S.
  • Journal Title: Blood. Volume: 128 Pages: 2863-2866
  • DOI: 10.1182/blood-2016-06-723494
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents. (2016)
  • Author(s): Merlevede J, et al.
  • Journal Title: Nat Commun. Volume: 7 Pages: 10767
  • DOI: 10.1038/ncomms10767.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia. (2016)
  • Author(s): Maruyama H, Katagiri T, Kashiwase K, Shiina T, Sato-Otsubo A, Zaimoku Y, Maruyama K, Hosokawa K, Ishiyama K, Yamazaki H, Inoko H, Ogawa S, Nakao S.
  • Journal Title: Exp Hematol. Volume: 44 Pages: 931-939
  • DOI: 10.1016/j.exphem
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neoantigen Load, Antigen Presentation Machinery, and Immune Signatures Determine Prognosis in Clear Cell Renal Cell Carcinoma. (2016)
  • Author(s): Matsushita H, Sato Y, Karasaki T, Nakagawa T, Kume H, Ogawa S, Homma Y, Kakimi K.
  • Journal Title: Cancer Immunol Res. Volume: 4 Pages: 463-471
  • DOI: 10.1158/2326-6066.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. (2016)
  • Author(s): Mansouri L, et al.
  • Journal Title: Blood. Volume: 128 Pages: 2666-2670
  • DOI: 10.1182/blood-2016-03-704528
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. (2016)
  • Author(s): Madan V, et al.
  • Journal Title: Leukemia. Volume: 30 Pages: 1672-1681
  • DOI: 10.1038/leu.2016.237.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional characterization of a novel GFI1B mutation causing congenital macrothrombocytopenia. (2016)
  • Author(s): Kitamura K, Okuno Y, Yoshida K, Sanada M, Shiraishi Y, Muramatsu H, Kobayashi R, Furukawa K, Miyano S, Kojima S, Ogawa S, Kunishima S.
  • Journal Title: J Thromb Haemost. Volume: 14 Pages: 1462-1469
  • DOI: 10.1038/leu.2016.237.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression. (2016)
  • Author(s): Kim T, Yoshida K, Kim YK, Tyndel MS, Park HJ, Choi SH, Ahn JS, Jung SH, Yang DH, Lee JJ, Kim HJ, Kong G, Ogawa S, Zhang Z, Kim HJ, Kim DD.
  • Journal Title: Leukemia. Volume: 30 Pages: 295-302
  • DOI: 10.1038/leu.2015.264.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma. (2016)
  • Author(s): Ki Kim S, Ueda Y, Hatano E, Kakiuchi N, Takeda H, Goto T, Shimizu T, Yoshida K, Ikura Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Uemoto S, Chiba T, Ogawa S, Marusawa H.
  • Journal Title: Int J Cancer. Volume: 139 Pages: 2512-2518
  • DOI: 10.1002/ijc.30379
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genomic analysis of clonal origin of Langerhans cell histiocytosis following acute lymphoblastic leukaemia. (2016)
  • Author(s): Kato M, Seki M, Yoshida K, Sato Y, Oyama R, Arakawa Y, Kishimoto H, Taki T, Akiyama M, Shiraishi Y, Chiba K, Tanaka H, Mitsuiki N, Kajiwara M, Mizutani S, Sanada M, Miyano S, Ogawa S, Koh K, Takita J.
  • Journal Title: Br J Haematol. Volume: 175 Pages: 169-172
  • DOI: 10.1111/bjh.13841.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. (2016)
  • Author(s): Kataoka K,et al.
  • Journal Title: Nature. Volume: 534 Pages: 402-406
  • DOI: 10.1111/bjh.13841.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Variegated RHOA mutations in human cancers. (2016)
  • Author(s): Kataoka K, Ogawa S.
  • Journal Title: Exp Hematol. Volume: 44 Pages: 1123-1129
  • DOI: 10.1016/j.exphem.2016.09.002.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia. (2016)
  • Author(s): Inaguma Y, Akatsuka Y, Hosokawa K, Maruyama H, Okamoto A, Katagiri T, Shiraishi K, Murayama Y, Tsuzuki-Iba S, Mizutani Y, Nishii C, Yamamoto N, Demachi-Okamura A, Kuzushima K, Ogawa S, Emi N, Nakao S.
  • Journal Title: Br J Haematol. Volume: 172 Pages: 131-134
  • DOI: 10.1111/bjh.13464.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] PIEZO1 gene mutation in a Japanese family with hereditary high phosphatidylcholine hemolytic anemia and hemochromatosis-induced diabetes mellitus. (2016)
  • Author(s): Imashuku S, Muramatsu H, Sugihara T, Okuno Y, Wang X, Yoshida K, Kato A, Kato K, Tatsumi Y, Hattori A, Kita S, Oe K, Sueyoshi A, Usui T, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Kanno H.
  • Journal Title: Int J Hematol. Volume: 104 Pages: 125-129
  • DOI: 10.1007/s12185-016-1970-x.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan. (2016)
  • Author(s): Ikeda F, Toki T, Kanezaki R, Terui K, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Ogawa S, Ito E.
  • Journal Title: Int J Hematol. Volume: 103 Pages: 112-114
  • DOI: 10.1007/s12185-015-1891-0.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. (2016)
  • Author(s): Arashiki N, Takakuwa Y, Mohandas N, Hale J, Yoshida K, Ogura H, Utsugisawa T, Ohga S, Miyano S, Ogawa S, Kojima S, Kanno H.
  • Journal Title: Haematologica. Volume: 101 Pages: 559-565
  • DOI: 10.3324/haematol.2016.142273.
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Aberrant RNA Splicing in splicing facto-mutated Myelodysplastic Syndromes (2017)
  • Author(s): Seishi Ogawa
  • Organizer: ｍＲＮＡ Ｐｒｏｃｅｓｓｉｎｇ ａｎｄ Ｈｕｍａｎ Ｄｉｓｅａｓｅ
  • Place of Presentation: U.S.A
  • Year and Date: 2017-03-05 – 2017-03-05
  • Int'l Joint Research / Invited
• [Presentation] Genetic landscape of childhood acute myeloid leukemia (2016)
  • Author(s): Kenichi Yoshida
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川
  • Year and Date: 2016-12-15 – 2016-12-15
• [Presentation] Landscape of Driver Mutations and Their Clinical Impacts in Pediatric Acute Lymphoblastic Leukemia (2016)
  • Author(s): Hiroo Ueno, et al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-05 – 2016-12-05
  • Int'l Joint Research
• [Presentation] The Impact of Clonal Dynamics on Prognosis and Outcome in Myelodysplastic Syndromes (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-05 – 2016-12-05
• [Presentation] Whole-Genome Sequencing of Primary Central Nervous System Lymphoma and Diffuse Large B-Cell Lymphoma (2016)
  • Author(s): Kenichi Yoshidaet al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-05 – 2016-12-05
• [Presentation] Clinical significance of mutations and copy number lesions on prognosis of patients with MDS after unrelated bone marrow transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, et al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-03 – 2016-12-03
  • Int'l Joint Research
• [Presentation] Distinct genetic events in PNH and AA. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-02 – 2016-12-02
• [Presentation] がんにおけるクロマチン構造制御因子の異常 (2016)
  • Author(s): 吉田 健一
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30 – 2016-11-30
• [Presentation] A Novel Genetic Mechanism of Evading Anti-tumor Immunity in Multiple Human Cancers (2016)
  • Author(s): Seishi Ogawa
  • Organizer: Ｔｈｅ １ｓｔ Ｍｅｅｔｉｎｇ ｏｆ Ｔａｉｗａｎ ＹＬＨ Ｓｙｍｐｏｓｉｕｍ ｓｅｒｉｅｓ
  • Place of Presentation: Taiwan
  • Year and Date: 2016-11-26 – 2016-11-26
  • Int'l Joint Research / Invited
• [Presentation] 淡明細胞型腎細胞癌における血漿循環腫瘍DNA解析の有用性の検討 (2016)
  • Author(s): Yusuke Sato, Yoichi Fujii, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Makishima, Tohru Nakagawa, Haruki Kume, Satoru Miyano, Seishi Ogawa, Yukio Homma
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-13 – 2016-11-13
• [Presentation] Genomic approaches to uncover the clonal structure and oncogenic potential of liver cirrhosis (2016)
  • Author(s): Soo Ki Kim, Seishi Ogawa, Hiroyuki Marusawa
  • Organizer: The 24th Japanese Digestive Disease Week (JDDW) 2016
  • Place of Presentation: 神戸
  • Year and Date: 2016-11-13 – 2016-11-13
• [Presentation] Cancer immune evasion via the disruption of PD-L1 3’-UTR (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 第32回京都賞記念ワークショップ
  • Place of Presentation: 京都
  • Year and Date: 2016-11-12 – 2016-11-12
  • Invited
• [Presentation] 様々な悪性腫瘍におけるPD-L1を介する新たな免疫逃避機構の解明 (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 第５６回国際治療談話会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-10 – 2016-11-10
• [Presentation] Genetic landscape of primary central nervous system lymphoma (2016)
  • Author(s): Kenichi Yoshida,et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-15 – 2016-10-15
• [Presentation] Molecular profiling across different subtypes of B-cell lymphoma (2016)
  • Author(s): Yasunori Kogure, Keisuke Kataoka, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Tetsuichi Yoshizato, Yasunobu Nagata, Masashi Sanada, Motohiro Kato, Hiraku Mori, Yasuharu Sato, Tadashi Yoshino, Kengo Takeuchi, Yuichi Ishikawa, Satoru Miyano, Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-15 – 2016-10-15
• [Presentation] Progress in diagnosis and therapy in myelodysplastic syndromes. (2016)
  • Author(s): Yasuhito Nannya
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-15 – 2016-10-15
• [Presentation] Impact of somatic mutations on outcome in patients with MDS after stem-cell transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-14 – 2016-10-14
• [Presentation] The transcriptional and alternative splicing landscape of myelodysplastic syndromes (2016)
  • Author(s): Yusuke Shiozawa, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-14 – 2016-10-14
• [Presentation] Clinical Impact of Somatic Mutations on Clonal Evolution in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Biomarkers in AML. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] The biological characterization of Srsf2 P95H mutation in the pathogenesis of myelodysplasia (2016)
  • Author(s): Ayana Kon, Satoshi Yamazaki, Yusuke Shiozawa, Keisuke Kataoka, Yasunori Ota, Maiko Morita, Tetsuichi Yoshizato, Masashi Sanada, Kenichi Yoshida, Hideki Makisima, Yasuhito Nanya, Shinichi Kotani, June Takeda, Yosaku Watatani, Yotaro Ochi, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Prognostic Relevance of Integrated Molecular Profiling in Adult T-cell Leukemia/Lymphoma (2016)
  • Author(s): Yotaro Ochi, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Comparative mutational profiling of ATL and other PTCLs (2016)
  • Author(s): Yosaku Watatani, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Clonal evolution following azacitidine therapy in patients with high-risk myelodysplastic syndromes (2016)
  • Author(s): June Takeda, Kenichi Yoshida, Tetsuichi Yoshizato, Yusuke Shiozawa, Hideki Makishima, Yasuhito Nannya, Hiromichi Suzuki, Yuichi Shiraishi, Yusuke Okuno, Kenichi Chiba, Satoru Miyano, Masashi Sanada, Toru Kiguchi, Nobuaki Dobashi , Kensuke Usuki, Shigeru Chiba, Norio Asou, Yasuyuki Miyazaki, Tomoki Naoe, Hitoshi Kiyoi
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Landscape of MDS genomes as revealed by whole genome sequencing. (2016)
  • Author(s): Yasuhito Nannya, Kenichi Yoshida, Keisuke Kataoka, Yasunobu Nagata, Tetsuichi Yoshizato, Toru Kiguchi, Nobuaki Dobashi, Kensuke Usuki, Tomoki Naoe, Yukio Kobayashi, Hitoshi Kiyoi, Shigeru Chiba, Norio Aso, Yasushi Miyazaki, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] A Novel Genetic Mechanism of Evading Anti-tumor Immunity In Multiple Human Cancers (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 第７８回日本血液学会学術集会出
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-12 – 2016-10-12
• [Presentation] Biological roles and potential therapeutic targeting of spliceosome mutations in myelodysplasia (2016)
  • Author(s): Ayana Kon, Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-08 – 2016-10-08
• [Presentation] Clonal architecture in acquired aplastic anemia (2016)
  • Author(s): Tetsuichi Yoshizato, et al.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-08 – 2016-10-08
• [Presentation] 淡明細胞型腎細胞癌における血漿循環腫瘍DNA解析の有用性の検討 (2016)
  • Author(s): Yusuke Sato, Yoichi Fujii, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Makishima, Tohru Nakagawa, Haruki Kume, Satoru Miyano, Seishi Ogawa, Yukio Homma
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] The carcinogenic sequence in colitis-associated cancer (2016)
  • Author(s): Nobuyuki Kakiuchi, Kenichi Yoshida, Yusuke Shiozawa, Kenichi Chiba, Yuichi Shiraishi, Takaki Sakurai, Yoshiharu Sakai, Motoi Uchino, Seiichi Hirota, Hiroki Ikeuchi, Satoru Miyano, Hiroyuki Marusawa, Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] Genetic landscape of primary central nervous system lymphoma (2016)
  • Author(s): Kenichi Yoshida, Kenichi Chiba, Yusuke Okuno, Hiromichi Suzuki, Yuichi Shiraishi, Hiroko Tanaka, Yoshihiro Muragaki, Takashi Shiina, Satoru Miyano, Shigeru Chiba, Ryuya Yamanaka, Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] Clonal structure and oncogenic potential of liver cirrhosis tissues (2016)
  • Author(s): Soo Ki Kim, Kenichi Yoshida, Yoshihide Ueda, Sachiko Minamiguchi, Toshimi Kaido, Yuichi Shiraishi, Satoru Miyano, Hironori Haga, Shinji Uemoto, Hiroshi Seno, Seishi Ogawa, Hiroyuki Marusawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] Molecular profiling across different subtypes of B-cell lymphoma (2016)
  • Author(s): Yasunori Kogure, Keisuke Kataoka, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Motohiro Kato, Tadashi Yoshino, Kengo Takeuchi, Yuichi Ishikawa, Satoru Miyano, Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] Molecular basis of splicing factor-mutated myeloid neoplasms (2016)
  • Author(s): Yusuke Shiozawa,et al.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] Clonal evolution following azacitidine therapy in patients with high-risk my elodysplastic syndromes (2016)
  • Author(s): 竹田 淳恵、吉田 健一、牧島 秀樹、白石 友一、千葉 健一、千葉 滋、麻生 範雄、宮﨑 泰司、直江 知樹、清井 仁、宮野 悟、小川 誠司
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-07 – 2016-10-07
• [Presentation] The 75th Annual Meeting of the Japanese Cancer Association (2016)
  • Author(s): Akira Yokoyama, Hiromichi Suzuki, Tetsuichi Yoshizato, Yusuke Shiozawa, Yusuke Sato, Kosuke Aoki, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Shigeru Tsunoda, Masashi Sanada, Satoru Miyano, Manabu Muto, Seishi Ogawa
  • Organizer: Differential role of mutations in clonal evolution in esophaegal mucosal in high-risk individuals for cancer
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06 – 2016-10-06
• [Presentation] Impact of somatic mutations on outcome in patients with MDS after stem-cell transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, Yusuke Shiozawa, Kenichi Yoshida, Yoshiko Atsuta, Nannya Yasuhito, Hiromichi Suzuki, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kousuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06 – 2016-10-06
• [Presentation] Landscape of MDS genomes as revealed by whole genome sequencing. (2016)
  • Author(s): Yasuhito Nannya, Kenichi Yoshida, Keisuke Kataoka, Yasunobu Nagata, Tetsuichi Yoshizato, Shigeru Chiba, Norio Aso, Yasushi Miyazaki, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06 – 2016-10-06
• [Presentation] A Novel Genetic Mechanism of Evading Anti-tumor Immunity In Multiple Human Cancers (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 第７５回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-05 – 2016-10-05
• [Presentation] A Unique mechanism of cancer immune evasion (2016)
  • Author(s): Seishi Ogawa
  • Organizer: Ｓａｌａ Ｆｅｄｅｒｉｃａ Ｍｏｎｔｅｌｅｏｎｅ）ＱＯＬ－ＯＮＥ ＭＤＳ ａｎｄ ＡＭＬ ＭＥＥＴＩＮＧ
  • Place of Presentation: Italy
  • Year and Date: 2016-09-14 – 2016-09-14
  • Int'l Joint Research / Invited
• [Presentation] Prognostic Relevance of Integrated Molecular Profiling in Adult T-cell Leukemia/Lymphoma (2016)
  • Author(s): Yotaro Ochi, Keisuke Kataoka, Yasunobu Nagata, Akira Kitanaka, Jun-ichiro Yasunaga, Masako Iwanaga, Kisato Nosaka, Hidehiro Itonaga, Yositaka Imaizumi, Kotaro Shide, Yasushi Miyazaki, Akifumi Takaori-Kondo, Kazuya Shimoda, Masao Matsuoka, Toshiki Watanabe, Seishi Ogawa
  • Organizer: 第3回日本HTLV-1学会学術集会
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2016-08-27 – 2016-08-27
• [Presentation] ATLおよびT細胞リンパ腫における遺伝子変異プロファイルの解析 (2016)
  • Author(s): Yosaku Watatani, Yasuharu Sato, Kenji Nishida, Hiroaki Miyoshi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hiroo Ueno, Nobuyuki Kakiuchi, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Satoru Miyano, Koichi Ohshima, Tadashi Yoshino, Seishi Ogawa, Keisuke Kataoka
  • Organizer: 第3回日本HTLV-1学会学術集会
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2016-08-27 – 2016-08-27
• [Presentation] AML,MDSと遺伝子異常 (2016)
  • Author(s): Seishi Ogawa
  • Organizer: Ｔｈｅ Ｃａｎｃｅｒ Ｇｅｎｏｍｉｃｓ Ｓｙｍｐｏｓｉｕｍ
  • Place of Presentation: Soul
  • Year and Date: 2016-08-21 – 2016-08-23
  • Int'l Joint Research / Invited
• [Presentation] Clonal Dynamics in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The Japanese Society of Medical Oncology 2016 Annual Meeting
  • Place of Presentation: Kobe,Japan
  • Year and Date: 2016-07-29 – 2016-07-29
  • Invited
• [Presentation] A Novel Genetic Mechanism of Evading Anti-tumor Immunity In Multiple Human Cancers (2016)
  • Author(s): Seishi Ogawa
  • Organizer: Ｔｈｅ ５ｔｈ ＪＣＡ－ＡＡＡＣＲ Ｓｐｅｃｉａｌ Ｊｏｉｎｔ Ｃｏｎｆｅｒｅｎｃｅ
  • Place of Presentation: 千葉
  • Year and Date: 2016-07-14 – 2016-07-14
  • Int'l Joint Research / Invited
• [Presentation] Genetic landscape of primary central nervous system lymphoma (2016)
  • Author(s): Kenichi Yoshida, et al.
  • Organizer: The 21st Congress of European Hematology Association
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-11 – 2016-06-11
  • Int'l Joint Research
• [Presentation] Dynamics of Clonal Evolution in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: 21st Congress European Hematology Association（国際学会）
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-11 – 2016-06-11
  • Int'l Joint Research
• [Presentation] Impact of somatic mutations on outcome in patients with MDS after stem-cell transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, Yusuke Shiozawa, Kenichi Yoshida, Yoshiko Atsuta, Nannya Yasuhito, Hiromichi Suzuki, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kousuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 21st Congress of European Hematology Association
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-10 – 2016-06-10
  • Int'l Joint Research
• [Presentation] GENETIC PREDISPOSITIONS TO SPORADIC MYELOID NEOPLASMS CAUSED BY GERMLINE DDX41 MUTATIONS IN ASIAN AND CAUCASIAN POPULATIONS. (2016)
  • Author(s): June Takeda, Kenichi Yoshida, Hideki Makishima, Tetsuichi Yoshizato, Yusuke Shiozawa, Hiromichi Suzuki, Yuichi Shiraishi, Yusuke Okuno, Ayana Kon, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Chantana Polprasert, Jaroslaw P. Maciejewski, and Seishi Ogawa
  • Organizer: The 21st Congress of European Hematology Association （国際学会）
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-10 – 2016-06-10
  • Int'l Joint Research
• [Presentation] Clinical and biological landscape of driver mutations in pediatric acute lymphoblastic leukemia (2016)
  • Author(s): Hiroo Ueno, Yuka Yamashita Kenichi Yoshida, Yusuke Shiozawa, Satomi Ishida, Hiroyuki Tsukamoto, Mayumi Kibe, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Takao Deguchi, Atsushi Sato, Yoshiko Hashii, Toshihiko Imamura, Satoru Miyano, Seishi Ogawa, Keizo Horibe, Masashi Sanada
  • Organizer: The 21st European Hematology Association congress
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-09 – 2016-06-09
  • Int'l Joint Research
• [Presentation] Cohesin mutations and their functional implications (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 第２１回欧州血液学会
  • Place of Presentation: Denmark
  • Year and Date: 2016-06-07 – 2016-06-07
  • Int'l Joint Research / Invited
• [Presentation] MDS Genomics and its Clincial Implication. (2016)
  • Author(s): Hideki Makishima, Tetsuichi Yoshizato, Kenichi Yoshida, Yasunobu Nagata, Mikkael Sekeres, Yusuke Okuno, Yuichi Shiraishi, Shigeru Chiba, Satoru Miyano, Lee-Yung Shih, Torsten Haferlach, Seishi Ogawa, Jaroslaw Maciejewski.
  • Organizer: The 5th National Conference on Hematologic Oncology
  • Place of Presentation: Nanjing,China
  • Year and Date: 2016-05-21 – 2016-05-21
  • Int'l Joint Research / Invited
• [Presentation] Epigenetic & Genetic Alterations/Clonal Evolution in Bone Marrow Failure (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 5th TSH International SYmposium
  • Place of Presentation: Thai
  • Year and Date: 2016-05-18 – 2016-05-18
  • Int'l Joint Research / Invited
• [Presentation] Aplastic anemia and preleukemia (2016)
  • Author(s): Seishi Ogawa
  • Organizer: 2016 Justen Passwell Symposium
  • Place of Presentation: Israel
  • Year and Date: 2016-04-29 – 2016-04-29
  • Int'l Joint Research / Invited
• [Presentation] 淡明細胞型腎細胞癌における血漿循環腫瘍DNA解析の有用性の検討 (2016)
  • Author(s): Yusuke Sato, Yoichi Fujii, Tohru Nakagawa, Haruki Kume, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, Yukio Homma
  • Organizer: The 104th Annual Meeting of the Japanese Urological Association
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2016-04-23 – 2016-04-23
• [Presentation] Impact of Somatic Mutations on Outcome in Patients with MDS after Stem-Cell Transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, Yusuke Shiozawa, Kenichi Yoshida, Yoshiko Atsuta, Nannya Yasuhito, Hiromichi Suzuki, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kousuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, and Seishi Ogawa
  • Organizer: International Conference on Myelodysplastic Syndromes
  • Place of Presentation: Estoril,Portugal
  • Year and Date: 2016-04-14 – 2016-04-14
  • Int'l Joint Research
• [Presentation] Clonal Dynamics in Myelodysplastic Syndromes (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: International Conference on Myelodysplastic Syndromes
  • Place of Presentation: Estoril,Portugal
  • Year and Date: 2016-04-14 – 2016-04-14
  • Int'l Joint Research
• [Presentation] Cancer Genetics 4. (2016)
  • Author(s): Hideki Makishima, Tetsuichi Yoshizato, Kenichi Yoshida, Yasunobu Nagata, Mikkael Sekeres, Yusuke Okuno, Yuichi Shiraishi, Shigeru Chiba, Satoru Miyano, Lee-Yung Shih, Torsten Haferlach, Seishi Ogawa, Jaroslaw Maciejewski.
  • Organizer: The 13th International Congress of Human Genetics (ICHG2016)
  • Place of Presentation: 京都
  • Year and Date: 2016-04-07 – 2016-04-07
  • Int'l Joint Research / Invited