2019 Fiscal Year Final Research Report
Deeper and Precise Fluorescence Bioimaging through the Second Biological Window (SBW)
| Project Area | Resonance Biology for Innovative Bioimaging |
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| Project/Area Number |
15H05950
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
SOGA KOHEI 東京理科大学, 基礎工学部材料工学科, 教授 (50272399)
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| Co-Investigator(Kenkyū-buntansha) |
上村 真生 東京理科大学, 基礎工学部材料工学科, 講師 (80706888)
大久保 喬平 東京理科大学, 基礎工学部材料工学科, 助教 (20822951)
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| Project Period (FY) |
2015-06-29 – 2020-03-31
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| Keywords | SBW / 近赤外 / 透明 / イメージング / 三次元 / 温度 |
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| Outline of Final Research Achievements |
Along with the improvement and development of fluorescent imaging in SBW, which allows the visualization of cm-order deep tissue information and have been leadingly developed by the project leader’s group for the first time in the world, we have extracted the demands in close communication with life scientists who are imaging users and promoted the technology originated in Japan to them. In particular, in addition to the three issues we have been working on since the beginning of the planning, "Development of bright fluorescent probes for various imaging scenes", "Development of fine structure imaging system for imaging capillaries, nerves, and brain", "Three-dimensional imaging using CT and confocal principles that make use of the observation depth", in collaboration with other preplanned planning groups, we have pioneered innovative technologies such as new tissue clearance reagents and fluorescence temperature imaging.
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| Free Research Field |
材料工学
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| Academic Significance and Societal Importance of the Research Achievements |
第二の生体の窓と呼ばれる波長域における蛍光バイオイメージングは、代表者らが世界に先駆けて発表してきた研究成果である。これに基づき、新たな生体の可視化技術を開拓しつつその技術の普及を狙った本研究の意義は、生命科学の発展のみならず、我が国発の技術の新たな産業創出への接続の礎となるものである。さらに、温度の可視化をはじめとするこれまでにない生命現象にともなう可視化技術の創出は、生命機序の解明、これにともなう医学の発展に接続するものであり、経済効果も含めて社会の発展に資すると期待できる。
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