2019 Fiscal Year Final Research Report
Mechanism of host chromosome 4D response to viral infection
| Project Area | Chromosome Orchestration System |
|---|
| Project/Area Number |
15H05978
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition (2017-2019)
Akita University (2015-2016) |
|---|
Principal Investigator |
Imai Yumiko 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, プロジェクトリーダー (50231163)
|
|---|
| Project Period (FY) |
2015-06-29 – 2020-03-31
|
| Keywords | ウイルス感染 |
|---|
| Outline of Final Research Achievements |
Changes in higher epigenome of the host due to virus infection and interaction between virus and host epigenome were analyzed.The mechanism of higher epigenome operation was clarified, and based on these, the molecular basis of higher epigenome changes leading to the pathogenesis and severity of viral infections was elucidated using gene-deficient cells, mice, and mutant viruses.Next, we identified epigenomic modifications that lead to severe disease and explored their potential applications in early diagnosis and preemptive medicine.Furthermore, regarding epigenome modification involved in the pathogenesis, we searched for candidate compounds for anti-influenza drugs targeting this.Through the above, we aimed to acquire the academic base information for establishing a new treatment strategy for severe viral infections for which there is no effective treatment that leads to lifesaving.
|
| Free Research Field |
感染症・免疫研究分野
|
| Academic Significance and Societal Importance of the Research Achievements |
ウイルス感染に伴った高次エピゲノム変化を誘導する分子メカニズムに関して、最近染色体構造タンパク質としても注目されているコヒーシンの役割を検討し、がんや慢性呼吸器疾患といった宿主側の因子が、インフルエンザウイルス感染症の病態に及ぼす影響を高次エピゲノム変化の観点から解析した。これまでの検討から明らかになったウイルスタンパク質と相互作用するヒストンメチル化酵素に関して、研究協力者と協力しながら結晶構造解析を行う準備を進め、これまでにエピゲノム関連化合物のライブラリーを用いたスクリーニングで同定したウイルスの増殖を抑える化合物に関して、マウス感染モデルを用いてそのin vivoでの効果を検証した。
|
