2010 Fiscal Year Final Research Report
Mechanism of intracellular degradation through selective autophagy
| Project Area | Proteolysis in the Regulation of Biological Processes |
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| Project/Area Number |
18076002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKAI Yasuyoshi Kyoto University, 大学院・農学研究科, 教授 (60202082)
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| Co-Investigator(Kenkyū-buntansha) |
YURIMOTO Hiroya 京都大学, 大学院・農学研究科, 准教授 (00283648)
OKU Masahide 京都大学, 大学院・農学研究科, 助教 (10511230)
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| Project Period (FY) |
2006 – 2010
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| Keywords | オートファジー / ペルオキシソーム / 液胞 / ペキソファジー / 酵母 |
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| Research Abstract |
We elucidated novel functions of Vac8 in peroxisome degradation (pexophagy) and of Atg8 in regulating the vacuolar morphology. Furthermore, we revealed the molecular mechanisms of an autophagic pathway induced in the lag phase of yeasts and a pexophagy process responsible for infection of a plant pathogen fungus, discovering new physiological functions of autophagy.
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