2011 Fiscal Year Final Research Report
Elementary process of molecular recognition from cluster to cell
| Project Area | Molecular Science for Supra Functional Systems ? Development of Advanced Methods for Exploring Elementary Process |
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| Project/Area Number |
19056002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
FUJII Masaaki 東京工業大学, ソリューション研究機構, 教授 (60181319)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Makoto 東京工業大学, 資源化学研究所, 准教授 (60298172)
ISHIUCHI Shun-ichi 東京工業大学, 資源化学研究所, 助教 (40338257)
HASHIMOTO Kenro 首都大学東京, 理工学研究科, 准教授 (40202254)
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| Co-Investigator(Renkei-kenkyūsha) |
MISAWA Kentaro 東京工業大学, 資源化学研究所, 特任助教 (10431991)
MIYAZAKI Mitsuhiko 東京工業大学, 資源化学研究所, 助教 (00378598)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 生体関連分子 / レーザー分光 / レーザー蒸発法 / 超音速ジェット / 赤外分光 / 時間分解分光 / 質量分析 |
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| Research Abstract |
Various materials to increase the efficiency of laser desorption of nonvolatile biomolecules were explored. Gold nano particle and carbon black were concluded as the best materials. The development enables us to determine structures of catecholamines and related molecules systematically by their UV and IR spectra. Picosecond time-resolved IR spectroscopy was applied to ionization triggered water migration dynamics in acetanilide-water system. This revealed details of the dynamics of single water molecule from the molecular point of view for the first time. Vibrational sum-frequency generation and optical microscope were combined to develop an IR super-resolution microscopy. 14 times higher spatial resolution than the IR diffraction limit was achieved and internal structures of cells were successfully visualized.
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