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2009 Fiscal Year Self-evaluation Report

Host immune response and its regulation against malignant cells

Planned Research

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Project AreaImmunological Self Recognition and its Disorders
Project/Area Number 19059008
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

MINATO Nagahiro  Kyoto University, 医学研究科, 教授 (40137716)

Project Period (FY) 2007 – 2011
Keywordsがん免疫 / 白血病 / T細胞 / アナジー / G蛋白 / 免疫老化
Research Abstract

自然発症ガンの抑制制御に獲得免疫系を中心とする宿主応答が重要な役割を果たすことは、近年の研究により次第に明らかになりつつあるが、体内に発生する内因性変異細胞(ガン)に対して、個体は多くの場合必ずしも有効な免疫応答を発動しえないこともまたよく知られた事実である。その大きな理由の一つは、自己に由来する変異細胞に対する末梢性の自己不応答性(自己寛容)の誘導と成立にあると考えられる。本研究課題では、申請者が作成してきた自然発症白血病の遺伝子改変マウスモデルを駆使して、自己応答としての変異(白血病)細胞に対する免疫応答と寛容の分子機構およびその個体レベルにおける意義を解明し、これを基礎として自己変異細胞不応答性解除の方途の開発に資することを目的とする。

  • Research Products

    (17 results)

All 2010 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (2 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of l NZB/W F1 mice.2010

    • Author(s)
      Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, Kumagai S
    • Journal Title

      J. Immunol. 184

      Pages: 2337-2347

    • Peer Reviewed
  • [Journal Article] Memory phenotype PD-1+ CD4+ T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia.2009

    • Author(s)
      Shimatani K, Nakashima Y, Hattori M, Hamazaki Y, Minato N
    • Journal Title

      Proc. Nat. Acad. Sci. USA. 106

      Pages: 15807-15812

    • Peer Reviewed
  • [Journal Article] Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells.2009

    • Author(s)
      Katayama Y, Sekai M, Hattori M, Miyoshi I, Hamazaki Y, Minato N
    • Journal Title

      Blood 114

      Pages: 1768-1775

    • Peer Reviewed
  • [Journal Article] Essential role of Rap signal in pre-TCR mediatedα-selection inαβT cell development.2008

    • Author(s)
      Kometani K, Moriyama M, Nakashima Y, Katayama Y, Wang S-F, Saito T, Hattori M, Minato N
    • Journal Title

      Blood 112

      Pages: 4565-4573

    • Peer Reviewed
  • [Journal Article] Structure of the human programmed death (PD)-1 ligand and its complex with PD-1 that inhibits immune responses.2008

    • Author(s)
      Lin D Y, Tanaka Y, Iwasaki M, Gitttis A G, Su H-P, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi D N
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 3011-3016

    • Peer Reviewed
  • [Journal Article] Development of Notch-dependent T cell leukemia by deregulated Rap1 signaling.2008

    • Author(s)
      Wang S-F, Aoki M, Shinozuka Y, Nakashima Y, Tanaka H, Taniwaki F, Hattori M, Minato N
    • Journal Title

      Blood 111

      Pages: 3011-3016

    • Peer Reviewed
  • [Journal Article] PD-L1 and tumor-infiltrating CD8+ T lymphocytes are independent prognostic factors of human ovarian cancer.2007

    • Author(s)
      Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, Fujii S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 3360-3365

    • Peer Reviewed
  • [Journal Article] Intestinal tumors inactivated in TGF-b signaling secrete CCL9 and recruit CCR1+ myeloid cells that help invasion.2007

    • Author(s)
      Kitamura T, Kometani K, Hashiba H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo M.
    • Journal Title

      Nature Gen. 39

      Pages: 467-475

    • Peer Reviewed
  • [Journal Article] Regulation of immune responses and hematopoiesis by the Rap1 signal.2007

    • Author(s)
      Minato N, Kometani K, Hattori M.
    • Journal Title

      Adv. Immunol. 93(Review)

      Pages: 229-264

    • Peer Reviewed
  • [Journal Article] Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from claudin-expressing cells.2007

    • Author(s)
      Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott H, Matsumoto M, Minato N.
    • Journal Title

      Nature Immunol. 8

      Pages: 304-311

    • Peer Reviewed
  • [Presentation] Human gamma delta T cells and cancer immunotherapy2009

    • Organizer
      日本免疫学会シンポジウム
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
  • [Presentation] Memory phenotype PD-1^+ CD4^+ T cells expressing C/EBPa underlie the global T cell immunodepression in senescence and malignancy2009

    • Organizer
      KTCC国際シンポジウム
    • Place of Presentation
      京都大学医学部芝蘭会館(京都市)
    • Year and Date
      2009-06-01
  • [Book] Janeway's免疫生物学(原書第7版)

    • Publisher
      南江堂
  • [Remarks]

    • URL

      http://immself.umin.jp/

  • [Patent(Industrial Property Rights)] ビスフォスホン酸誘導体を含む医薬組成物2009

    • Inventor(s)
      田中義正、林衡佑、松本健司、湊長博
    • Industrial Property Rights Holder
      京都大学、アステラス製薬
    • Industrial Property Number
      国際特許・2009-207958
    • Filing Date
      2009-09-09
  • [Patent(Industrial Property Rights)] 新規リンパ球処理剤2009

    • Inventor(s)
      田中義正、湊長博
    • Industrial Property Rights Holder
      京都大学、アステラス製薬
    • Industrial Property Number
      国際特許・2009-162430
    • Filing Date
      2009-07-09
  • [Patent(Industrial Property Rights)] 細胞表面機能分子の細胞外領域多量体2007

    • Inventor(s)
      田中義正、湊長博
    • Industrial Property Rights Holder
      京都大学、小野薬品
    • Industrial Property Number
      PCT国際出願・PCT/JP2007/54052
    • Filing Date
      2007-03-02

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Published: 2011-06-18   Modified: 2016-04-21  

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