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2023 Fiscal Year Final Research Report

Mathematical analyses for oscillatory behaviors in plants by integrating molecular dynamics and cellular mechanics

Planned Research

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Project AreaIntrinsic periodicity of cellular systems and its modulation as the driving force behind plant development
Project/Area Number 19H05678
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Mochizuki Atsushi  京都大学, 医生物学研究所, 教授 (10304726)

Project Period (FY) 2019-06-28 – 2024-03-31
Keywords数理モデル / ダイナミクス / 形態形成 / 構造感度解析 / 構造分岐解析 / 細胞周期 / ネットワーク
Outline of Final Research Achievements

In this study, we used mathematical methods to investigate the mechanisms that create characteristic plant morphogenesis from two levels: (1) biomolecular dynamics and (2) cellular mechanics. We have extended our structural theory to mathematically determine (i) the conditions of biomolecular interactions under which periodic behaviors emerge and (ii) the effects of modulation of cellular properties on organ morphology. Using these, we (ii) collaborated with experimental groups to elucidate the mechanisms of various morphogenetic phenomena observed in plant morphogenesis through a combination of theoretical predictions and experimental validation.

Free Research Field

理論生物学

Academic Significance and Societal Importance of the Research Achievements

植物個体の形態形成は、細胞内生体分子のダイナミクスによって細胞分裂や細胞伸長などの細胞の振る舞いが規定され、細胞間相互作用が変調することで形態の調節がなされるのだ、と考えられる。これらを実現する分子メカニズムや、細胞の性質がもたらす形態形成への効果について、理論と実験の組み合わせにより解明をすすめた。研究全体を通じて、生命の時空間ダイナミクスに対して、理論と実験の組み合わせから解明に迫るための方法を構築した。

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Published: 2025-01-30  

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