2012 Fiscal Year Final Research Report
Regulatory mechanism of the cell integrity signaling mediated by mRNA-binding proteins
| Project Area | Diversity and asymmetry achieved by RNA program |
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| Project/Area Number |
20112008
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | MAPキナーゼシグナル / RNA結合タンパク質 / RNA顆粒 / mRNA安定性 / 分子遺伝学 / 分裂酵母モデル生物 / 細胞内シグナル伝達 |
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| Research Abstract |
We identified the mRNA-binding protein Nrd1 and demonstrated that Nrd1 binds to and regulates mRNA stability of the Myosin mRNA. We also showed that Pmk1 MAPK, a homologue of ERK in fission yeast regulates the RNA-binding activity of Nrd1 in a phosphorylation-dependent manner. Moreover, Nrd1 translocated to the stress granules in a MAPK-mediated phosphorylation-dependent manner, thereby regulates stress tolerance in fission yeast.
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[Journal Article] Sip1, a Conserved AP-1 Accessory Protein, is Important for Golgi/Endosome Trafficking in Fission Yeast2012
Author(s)
Yu Y, Kita A, Udo M, Katayama Y, Shintani M, Park K, Hagihara K, Umeda N, Sugiura R
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Journal Title
PLoS ONE
Volume: 7(9)
Pages: e45324
DOI
Peer Reviewed
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[Journal Article] The Cell Surface Protein Gene ecm33+ Is a Target of the Two Transcription Factors Atf1 and Mbx1 and Negatively Regulates Pmk1 MAPK Cell Integrity Signaling in Fission Yeast2010
Author(s)
Takada H, Nishida A, Domae M, Kita A, Yamano Y, Uchida A, Ishiwata S,Fang Y, Zhou X, Masuko T, Kinoshita M, Kakehi K, Sugiura R
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Journal Title
Mol Biol Cell
Volume: 21(4)
Pages: 674-85
DOI
Peer Reviewed
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