2012 Fiscal Year Final Research Report
Study on pathophysiological mechanisms and therapeutic strategies of the deficits in face perception
| Project Area | Clarification of the mechanism of face recognition by interdisciplinary research |
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| Project/Area Number |
20119003
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
INAGAKI Masumi 独立行政法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 部長 (70203198)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Yuki (独)国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 室長 (現 島田療育センター八王子 医長) (40415576)
OHTA Hidenobu (独)国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 室長 (80422103)
GUNJI Atsuko (独)国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 室長 (70392446)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 発達障害 / 顔認知障害 / 事象関連電位 / 周波数解析 / 自他識別 / 視線追跡 / 非侵襲的脳機能測定法 |
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| Research Abstract |
To evaluate difficulty in social cognition in children with ASD objectively, we indicate the brain responses to semantic processing in face recognition. Analysis of hemodynamic activities and electroencephalography (EEG) oscillation indicated activation in the inferior frontal gyrus (IFG) of right hemisphere related to semantic processing of face (i.e. self-other, familiarity and expression) in healthy adults and typically-developing children. Averaged EEG (P300) technique also detected the effect of self-other and familiarity discrimination. In children with ASD, however, the semantic processing of face did not reflect in hemodynamic activities of the right IFG and P300 amplitude, except for familiarity- related P300 to learn new faces. The techniques might be useful as a clinical application to evaluate specificity in the semantic processing of face in children with ASD.
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[Journal Article] Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography.2009
Author(s)
Ishii R, Canuet L, Herdman A, Gunji A, Iwase M, Takahashi H, Nakahachi T, Hirata M, Robinson SE, Pantev C, Takeda M
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Journal Title
Clin Neurophysiol.
Volume: 120
Pages: 497-504
DOI
Peer Reviewed
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[Presentation] Facial identity recognition in children with autism spectrum disorders revealed by P300 analysis.2012
Author(s)
Gunji A, Goto T, Kita Y, Sakuma R, Kokubo N, Koike T, Sakihara S, Kaga M, Inagaki M
Organizer
International Conference of NIPS (National Institute for Physiological Sciences): Face perception and recognition.
Place of Presentation
NIPS, Okazaki, Japan
Year and Date
20121031-1103
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