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2013 Fiscal Year Final Research Report

Generation of meta-rule through dynamical systems with multiple timescales: towards a theory of learning and evolution

Planned Research

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Project AreaThe study on the neural dynamics for understanding communication in terms of complex hetero systems
Project/Area Number 21120004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

KANEKO Kunihiko  東京大学, 総合文化研究科, 教授 (30177513)

Project Period (FY) 2009-07-23 – 2014-03-31
Keywords力学系 / カオス的遍歴 / 可塑性 / 学習 / 進化
Research Abstract

Biological systems consists of hierarchy with different time scales.
Slow units provide a rule for faster units, while the former are changed by the latter, as seen in the relation between synapse change and neural activity in learning, or phenotypic change by the genotype in evolution. Development and adaptation also consist of such hierarchy of time scales. We study such dynamics of dynamical systems; (1)memory and learning of input-output relationship as bifurcation(2) stem cell differentiation as interaction-induced bifurcation of intra-cellular dynamical systems (3)high-dimensional adaptation dynamics (4)evolutionary correspondence between genotypic variation and phenotypic dynamics; evolution of rules of robust dynamics (5) chaotic itinerancy of fast-slow dynamics. With this study, we uncover how heterogeneous dynamical systems lead to plastic and robust generation of rules that govern the system itself, thereby providing a basis for mathematical study of biological systems

  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (5 results) Book (1 results)

  • [Journal Article] The Baldwin effect under multi-peaked fitness landscapes : Phenotypic fluctuation acceleratesevolutionary rate2013

    • Author(s)
      N. Saito, S. Ishihara, and K. Kaneko
    • Journal Title

      Phys. Rev. E

      Volume: 87 Pages: 052701

    • DOI

      10.1103/PhysRevE.87.052701

    • Peer Reviewed
  • [Journal Article] Embedding Responses in Spontaneous Neural Activity Shaped through Sequential Learning2013

    • Author(s)
      T. Kurikawa and K. Kaneko
    • Journal Title

      PLoS Computational Biology

      Volume: 9 Pages: e1002943

    • DOI

      10.1371/journal.pcbi.1002943

    • Peer Reviewed
  • [Journal Article] Minimal Model for Stem-Cell Differentiation2013

    • Author(s)
      Y. Goto and K. Kaneko
    • Journal Title

      Phys. Rev. E

      Volume: 88(2013) Pages: 032718

    • DOI

      10.1103/PhysRevE.88.032718

    • Peer Reviewed
  • [Journal Article] Cooperative Adaptive Response in Gene Regulatory Networks with Many Degrees of Freedom2013

    • Author(s)
      M. Inoue, K. Kaneko
    • Journal Title

      PLoS Computational Biology

      Volume: Vol.9, Issue 4 Pages: e1003001

    • DOI

      10.1371/journal.pcbi.1003001

    • Peer Reviewed
  • [Journal Article] Slow Stochastic Switching by Collective Chaos of Fast Elements2013

    • Author(s)
      H. Aoki and K. Kaneko
    • Journal Title

      Phys. Rev. Lett.

      Volume: 111 Pages: 144102

    • DOI

      10.1103/PhysRevLett.111.144102

    • Peer Reviewed
  • [Journal Article] Evolution of Robustness and Plasticity under Environmental Fluctuation : Formulation in terms of Phenotypic Variances2012

    • Author(s)
      K. Kaneko
    • Journal Title

      J. Stat. Phys.

      Volume: 148 Pages: 686-704

    • DOI

      10.1007/s10955-012-0563-1

    • Peer Reviewed
  • [Journal Article] Replica symmetry breaking in an adiabatic spin-glass model of adaptive evolution2012

    • Author(s)
      A. Sakata, K. Hukushima and K. Kaneko
    • Journal Title

      Europhys. Lett.

      Volume: 99 Pages: 68004

    • DOI

      10.1209/0295-5075/99/68004

    • Peer Reviewed
  • [Journal Article] Associative Memory Model with the Spontaneous neural Activity2012

    • Author(s)
      T. Kurikawa and K. Kaneko
    • Journal Title

      Europhys. Lett.

      Volume: 98 Pages: 48002

    • DOI

      10.1209/0295-5075/98/48002

    • Peer Reviewed
  • [Journal Article] A Dynamical-Systems View of Stem Cell Biology2012

    • Author(s)
      C. Furusawa and K. Kaneko
    • Journal Title

      Science

      Volume: 338 Pages: 215-217

    • DOI

      10.1126/science.1224311

    • Peer Reviewed
  • [Journal Article] Adaptation to optimal cell growth through self-organized criticality2012

    • Author(s)
      C. Furusawa and K. Kaneko
    • Journal Title

      Phys. Rev. Lett.

      Volume: 108 Pages: 208103

    • DOI

      10.1103/PhysRevLett.108.208103

    • Peer Reviewed
  • [Journal Article] Learning Shapes Spontaneous Activity Itinerating overMemorized States2011

    • Author(s)
      T. Kurikawa and K. Kaneko
    • Journal Title

      PLoS One

      Volume: 6 Pages: e17432

    • DOI

      10.1371/journal.pone.0017432

    • Peer Reviewed
  • [Journal Article] Oscillatory Protein Expression Dynamics Endows Stem Cells with Robust DifferentiationPotential2011

    • Author(s)
      N. Suzuki, C. Furusawa, and K. Kaneko
    • Journal Title

      PLoS One

      Volume: 6 Pages: e27232

    • DOI

      10.1371/journal.pone.0027232

    • Peer Reviewed
  • [Journal Article] Characterization of stem cells and cancer cells on the basis of gene expression profile stability, plasticity and robustness2011

    • Author(s)
      K. Kaneko
    • Journal Title

      Bioessays

      Volume: 33 Pages: 403-413

    • DOI

      10.1002/bies.201000153

    • Peer Reviewed
  • [Presentation] Plasticity and Robustness in Evolution : Macroscopic Theory, Model Simulations, and Laboratory Experiments -Part I&II2013

    • Author(s)
      K. Kaneko
    • Organizer
      Quantitative Laws of Genome Evolution
    • Place of Presentation
      Villa del Grumello (Como,イタリア)
    • Year and Date
      2013-07-02
  • [Presentation] Dynamical-Systems Perspective to Stem-cell Biology : Relevance of oscillatory gene expression dynamics and cell-cell interaction2013

    • Author(s)
      K.Kaneko
    • Organizer
      Symposium on Systems Biology of Stem Cells
    • Place of Presentation
      Beckman center (Irvine,米国)
    • Year and Date
      2013-06-10
  • [Presentation] Characterization of stem cells and cancer cells on the basis of gene expression dynamics and robustness2012

    • Author(s)
      K. Kaneko
    • Organizer
      Sumeer school"DNA synamics and life strategies"
    • Place of Presentation
      Krogerup Hoejskole(デンマーク)
    • Year and Date
      2012-08-15
  • [Presentation] Phenotypic fluctuations, developmental Plasticity, and environmental variation2012

    • Author(s)
      K. Kaneko
    • Organizer
      Euro Evo Devo
    • Place of Presentation
      Univ. ofLisbon (Lisbon,ポルトガル)
    • Year and Date
      2012-07-12
  • [Presentation] Evolution of Robustness formulated in terms of Phenotypic Variances2012

    • Author(s)
      K. Kaneko
    • Organizer
      Workshop 3: Robustness in Biological Systems
    • Place of Presentation
      オハイオ(米国)
    • Year and Date
      2012-02-06
  • [Book] "Phenotypic Plasticity and Robustness : Evolutionary Stability Theory, Gene Expression Dynamics Model, and Laboratory Experiments "Evolutionary Systems Biology2012

    • Author(s)
      K. Kaneko(ed. O. Soyer)
    • Publisher
      Springer

URL: 

Published: 2015-06-25  

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