Functionalization of Unactivated Bonds by Cooperative Metal Catalysis

2014 Fiscal Year Final Research Report

• Project Area: Molecule Activation Directed toward Straightforward Synthesis
• Project/Area Number: 22105003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyoto University
• Principal Investigator: NAKAO Yoshiaki 京都大学, 工学(系)研究科(研究院), 教授 (60346088)
• Co-Investigator(Renkei-kenkyūsha): SEMBA Kazuhiko 京都大学, 大学院工学研究科, 助教 (30712046)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 協働金属触媒 / 遷移金属 / ルイス酸 / 不活性結合

Outline of Final Research Achievements

We have investigated novel synthetic reactions involving direct activation and functionalization of common chemical bonds of organic molecules by cooperative metal catalysis. We have developed reactions involving C-H and C-C bond activation followed by their functionalization to form new C-C bonds by cooperative Ni/Al catalysis, regioselective borylation of heteroarene C-H bonds by cooperative Ir/Al catalysis, and direct functionalization of C-O and C-N bonds by cooperative Pd/B catalysis.

Free Research Field

有機合成化学