Creation of Transition-metal-Oxido Complexes for Direct C-H Bond Hydroxylation

2015 Fiscal Year Final Research Report

• Project Area: Molecule Activation Directed toward Straightforward Synthesis
• Project/Area Number: 22105007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka University
• Principal Investigator: Itoh Shinobu 大阪大学, 工学(系)研究科(研究院), 教授 (30184659)
• Co-Investigator(Renkei-kenkyūsha): SUGIMOTO Hideki 大阪大学, 大学院工学研究科, 准教授 (00315970) ; FUJIEDA Nobutaka 大阪大学, 大学院工学研究科, 助教 (00452318) ; MORIMOTO Yuma 大阪大学, 大学院工学研究科, 特任助教 (20719025)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: オキソ錯体 / 水酸化反応 / 触媒 / 銅 / ニッケル / オスミウム / ジオール化

Outline of Final Research Achievements

Selective hydroxylation of hydrocarbons is one of the most important but is still very difficult chemical transformation reactions in synthetic organic chemistry and industrial chemistry. In this study, we have developed transition-metal active-oxygen speceis supported by simple pyridyl(alkylamine) ligands, which are capable of performing selective hydroxylation reactions of aliphatic and aromatic compounds using molecular oxygen or hydrogen peroxide as an oxidant. We have also succeeded to developed osmium complexes supported by the same series of pyridyl(alkylamine) ligands, which can catalyze efficient cis-dihydroxylation and 1,2-aminohydroxylation reactions of olefins. Mechanistic studies on the above reactions have been performed in detail to get insights into the structure and properties of the transition-metal active-oxygen intermediates.

Free Research Field

錯体化学