2014 Fiscal Year Final Research Report
Regulation of High Specificity and Function of Biological Reaction Sphere
Project Area | Molecule Activation Directed toward Straightforward Synthesis |
Project/Area Number |
22105012
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Science and Engineering
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
SHIRO Yoshitsugu 独立行政法人理化学研究所, 放射光科学総合研究センター, 主任研究員 (70183051)
|
Project Period (FY) |
2010-04-01 – 2015-03-31
|
Keywords | 金属酵素 / 一酸化窒素 / 一酸化窒素還元酵素 / 人工触媒 / ヘム酵素 / 脱窒 |
Outline of Final Research Achievements |
In this study, we have been studying nitric oxide reductase (NOR), which catalyzes NO reduction to N2O in anaerobic respiration (denitrification) of bacteria. We succeeded in proposing the molecular mechanism of the NOR reaction on the basis of its molecular structure, in which the N-O bond is cleaved and the N-N bond is formed. The results provided us the new insight into development of a new type of the catalyst, since NOR utilizes two-iron-complex as the active center, instead of rare-metals, which are usually used in the organic synthesis. In addition, our study can contribute to the discussion of the molecular evolution of the respiratory enzymes on the earth, which was evolved from anaerobic (non-oxygen) to aerobic (oxygen) respiration.
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Free Research Field |
化学
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