Understanding the neuronal dysfunction/neurocircuit pathology based on iPSC technology

2014 Fiscal Year Final Research Report

• Project Area: Generation of synapse-neurocircuit pathology
• Project/Area Number: 22110007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: INOUE Haruhisa 京都大学, iPS細胞研究所, 教授 (70332327)
• Co-Investigator(Kenkyū-buntansha): SAKURAI Takashi 順天堂大学, 医学部, 教授 (70225845) ; HIOKI Hiroyuki 京都大学, 医学研究科, 助教 (00402850) ; EGAWA Naohiro 京都大学, iPS細胞研究所, 特定研究員 (20534340) ; KITAOKA Shiho 京都大学, iPS細胞研究所, 特定研究員 (00545246)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 脳神経疾患 / 脳・神経 / 神経科学

Outline of Final Research Achievements

In this research area, we have developed neuro-imaging, gene-knock-in in human iPSCs, and rapid neuro-differentiation technologies. Using these technologies, we generated and analyzed ALS motor neurons and found novel pathogenesis (Sci Transl Med 2012). Also, we generated cortical neurons and astrocytes from Alzheimer’s patients, and found a new direction of medicine (Cell Stem Cell 2013). Furthermore, we showed the potential of human iPSCs as a cellular resource for ALS transplantation therapy (Stem Cell Reports 2014).
We have promoted collaborative works with other members in this area by sharing our technology.

Free Research Field

幹細胞医学分野