2014 Fiscal Year Final Research Report
Development of anti-cancer drugs specific to tumor microenvironments
| Project Area | Integrative Research on Cancer Microenvironment Network |
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| Project/Area Number |
22112009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 低酸素 / HIF / バイオセンサー / タンパク質製剤 / 骨転移 |
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| Outline of Final Research Achievements |
Tumor microenvironment has been suggested to play important roles in malignant progression and be associated with poor prognosis. Because many tumor microenvironmental factors are shared among various cancers, materials specific to the factors may be useful for developing versatile therapeutic strategies. In this study, we focused on hypoxia, one of the main characteristics of tumor microenvironment, and searched factors closely associated with hypoxia-inducible transcription factor HIF in vivo. First, we noninvasively monitored the cancer cell response to hypoxia, inflammation, and angiogenesis to understand the status of cancer cells in vivo by using multi-bioluminescence imaging systems, which we had newly established. Second, we isolated a highly lung metastatic subline from a non-metastatic osteosarcoma cell line and searched factors responsible for lung metastasis. We successfully identified some candidate factors and are investigating their involvement in lung metastasis.
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| Free Research Field |
分子腫瘍学、生体イメージング
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