Development of novel therapy targeting microenvironment in respiratory malignancy

2014 Fiscal Year Final Research Report

• Project Area: Integrative Research on Cancer Microenvironment Network
• Project/Area Number: 22112010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kanazawa University
• Principal Investigator: YANO Seiji 金沢大学, がん進展制御研究所, 教授 (30294672)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takeshi 金沢大学, がん進展制御研究所, 教授 (30262075) ; NISHIOKA Yasuhiko 徳島大学, ヘルスバイオサイエンス研究部, 教授 (70274199) ; EBI Hiromichi 金沢大学, がん進展制御研究所, 助教 (00645145)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 微小環境 / 分子標的薬耐性 / EGFR変異肺がん / ALK肺がん / 中皮腫

Outline of Final Research Achievements

We found that microenvironment-derived growth factors, including HGF, induced resistance to tyrosine kinase inhibitors in EGFR mutant or ALK-fusion gene positive lung cancer. The resistance caused by microenvironment could be overcome by concomitant inhibition of growth factor receptors. In the orthotopic model of mesothelioma, we discovered that mesothelioma cells and fibroblasts formed the vicious cytokine network and promoted tumor progression, indicating that factors involved in this network would be ideal therapeutic targets for mesothelioma.

Free Research Field

腫瘍内科