2014 Fiscal Year Final Research Report
Two-photon imaging of cellular function in tumor immunity and immune dysregulation
Project Area | Mutli-dimensional fluorescence live imaging of cellular function and molecular activity |
Project/Area Number |
22113006
|
Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
OKADA Takaharu 独立行政法人理化学研究所, その他部局等, その他 (50452272)
|
Project Period (FY) |
2010-04-01 – 2015-03-31
|
Keywords | イメージング / 免疫 |
Outline of Final Research Achievements |
Germinal centers are the important site for the production of high affinity antibodies against pathogenic microbes. Our study revealed where in the lymphoid tissues B cells become committed to differentiation to germinal center B cells. Real time imaging analyses showed that the transcription factor Bcl6 plays an important role in B cell immigration into germinal centers. Imaging analyses also revealed that S1PR2, a receptor for sphingosine-1-phosophate, expressed by germinal center helper T cells is critical for their retention in germinal centers. In addition, our imaging analyses identified a subset of dendritic cells that is likely to be the most important for cytotoxic T lymphocyte development and differentiation, which are critical for tumor immunity.
|
Free Research Field |
医歯薬学
|