Development of cancer-controlling vector conversion techniques using nano-DDS

2014 Fiscal Year Final Research Report

• Project Area: Conversion of tumor-regulation vector to intercept oncogenic spiral accelerated by infection and inflammation
• Project/Area Number: 22114009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: AKIYOSHI Kazunari 京都大学, 工学(系)研究科(研究院), 教授 (90201285)
• Co-Investigator(Kenkyū-buntansha): SHINYA Masaharu 京都府立医科大学, 医学部, 研究員 (10405277) ; MATSUDA Osamu 京都府立医科大学, 医学研究科, 教授 (00271164)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ドラッグデリバリーシステム / がん治療 / ナノゲル / ワクチン / エクソソーム

Outline of Final Research Achievements

The aim of this research project is to invent new technologies to fully control the delivery, expression, and sustained release of bioactive molecules, such as DNA, siRNA, and proteins, by further modifying existing nanogel DDSs. We newly developed polysaccharide-nanogels for nucleic acids (CpG, siRNA) delivery systems. We succeeded to control cancer microenvironments and to reduce the growth of cancers by using nanogel-siRNA delivery system.

Free Research Field

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