Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Neuronaal circuits of mammals are matured after extensive remodeling during postnatal development. In this project, we have developed a method for sparse and bright neuron labeling in vivo, and by using it we achieved in vivo time lapse imaging of dendritic remodeling of single cortical neurons in neonatal mouse. Furthermore, by combining novel single-cell gene targeting technology, we have revealed a role of NMDA-type glutamate receptors for the developmental circuit remodeling.
Attribution of KAKENHI