Leukotriene receptors and new lipid ligands

2014 Fiscal Year Final Research Report

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 22116002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Juntendo University (2012-2014); Kyushu University (2010-2011)
• Principal Investigator: YOKOMIZO Takehiko 順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
• Co-Investigator(Kenkyū-buntansha): SAEKI Kazuko 順天堂大学, 大学院医学研究科, 准教授 (00553273)
• Co-Investigator(Renkei-kenkyūsha): OKUNO Toshiaki 順天堂大学, 大学院医学研究科, 准教授 (60361466)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ロイコトリエン / アラキドン酸 / 受容体 / アスピリン / 非ステロイド性消炎鎮痛剤 / 皮膚潰瘍

Outline of Final Research Achievements

A G-protein coupled receptor BLT2 is expressed in epithelial cells, and important in interstinal barrier function and epidermal wound healing. Nonsteroidal anti-inflammatory drugs including aspirin delays skin wound healing by inhibiting the production of 12-HHT, a BLT2 ligand. A synthetic BLT2 agonist is a drug candidate for intractable skin ulcer in the future. Zebrafish embryogenesis requires BLT1 and BLT2. Gene knockout studies showed that BLT1 augments multiple sclerosis, and delays the recovery from spinal injury. BLT2 seems to attenuate asthmatic responses.

Free Research Field

生化学、分生生物学、免疫学