Genes/SNPs of lipid mediators and diseases

2014 Fiscal Year Final Research Report

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 22116010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: YUTAKA Kiyohara 九州大学, 医学(系)研究科(研究院), 教授 (80161602)
• Co-Investigator(Kenkyū-buntansha): KUBO Michiaki 理化学研究所, 総合生命医科学研究センター, 副センター長 (30442958) ; NINOMIYA Toshiharu 九州大学, 大学院医学研究院, 教授 (30571765) ; HATA Jun 九州大学, 大学院医学研究院, 准教授 (00448432)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 脂質メディエーター / 遺伝子多型 / エイコサペンタエン酸 / アラキドン酸 / ビタミンD / 心血管病 / 悪性腫瘍 / 慢性腎臓病

Outline of Final Research Achievements

We examined the associations of lipid mediators or their genetic polymorphysms with common diseases in inhabitants of Hisayama Town, Fukuoka. The association study of genetic polymorphisms and common diseases revealed that a polymorphism in PLA2G3 gene was associated with serum HDL cholesterol concentration, and a polymorphism in PA-PLA1 was correlated with body mass index. The cohort study in Hisayama demonstrated that a lower ratio of serum eicosapentaenoic acid to arachidonic acid was a risk factor for the development of coronary heart disease and death from malignant tumors, and that a decreased level of serum 1,25-dihydroxy-vitamin D was associated with an increased risk of chronic kidney disease.

Free Research Field

生活習慣病の疫学