2014 Fiscal Year Final Research Report
Structural basis for protein posttranscriptional modifications and cellular signaling
| Project Area | Regulation of signal transduction by post-translational modifications and its pathogenic dysregulation |
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| Project/Area Number |
22117007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | X線結晶構造解析 / タンパク質翻訳後修飾 / 細胞内シグナル伝達 / NF-κBシグナル伝達経路 |
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| Outline of Final Research Achievements |
Post-translational modifications play critical roles in the regulation of signal transduction and cellular functions. Structural biology methods, including X-ray crystallography, are powerful tools for dissecting the molecular interaction mechanisms between the factors involved in these signaling pathways. Therefore, synergetic approaches by structural, molecular and cellular biology are important to understand both the mechanisms of signal transduction by post-translational modifications and their pathogenic dysregulation. Our results of the structural analyses of cGAS, A20-ZF7-linear ubiquitine complex, and HHM highlight the importance of synergetic approaches by collaborations between different biological fields.
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| Free Research Field |
構造生物学
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