2015 Fiscal Year Final Research Report
Searching for signaling molecules in neuro-vascular interaction
Project Area | Vasculo-neural wiring and their interdependent crosstalk |
Project/Area Number |
22122008
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | The University of Tokyo (2013-2015) Osaka Bioscience Institute (2010-2012) |
Principal Investigator |
Emoto Kazuo 東京大学, 理学(系)研究科(研究院), 教授 (80300953)
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Co-Investigator(Kenkyū-buntansha) |
Koizumi Hiroyuki 東京大学, 大学院理学系研究科, 助教 (10334335)
Kanai Makoto 大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (50598034)
Kanamori Rei (Morikawa Rei) 大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (50534575)
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Project Period (FY) |
2010-04-01 – 2016-03-31
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Keywords | ショウジョウバエ / 末梢感覚ニューロン / 気管 / 伴走構造 / NCAM |
Outline of Final Research Achievements |
To identify molecules involved in neuro-vascular interaction, we screened molecules involved in neuro-trachea interaction in Drosophila as a model for neuro-vascular interaction. We conducted an RNAi screen for ~100 candidate molecules and found that FasII/NCAM, an adhesion molecule of IgG superfamily, mediates interaction between trachea and axons of sensory neurons in wing disc, which likely navigates afferent axons to the central nervous system.
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Free Research Field |
発生生物学、神経科学、細胞生物学
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