2014 Fiscal Year Final Research Report
Chromosome dynamics and genome adaptation during meiosis
| Project Area | Systematic study of chromosome adaptation |
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| Project/Area Number |
22125002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 染色体 / ゲノム / 染色体適応 / 減数分裂 / 組換え |
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| Outline of Final Research Achievements |
Genome adaptation during meiosis promotes new combination of genetic information in next generation. A DNA exchange reaction, homologous recombination plays a critical role in genome adaption. However, it still remains how recombination during meiosis is controlled at a molecular levels and how chromosome dynamics regulate the reaction. In this study, we found : 1. Transcription coupling epigenetic marks regulates the initiation of the meiotic recombination. 2. Post-translational modification of the proteins in nuclear envelope regulates the recombination through control of chromosome dynamics. 3 Crystal structural analysis of the protein complex involved in meiotic recombination provide a novel insight on the mechanism of the homology search in the recombination. Given the dysfunction of genome adaptation confers genome instability in gametes, which are often associated with miscarriage and Down syndrome, our knowledge might contribute prevention of age-dependnet miscarriage in human.
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| Free Research Field |
分子生物学
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