Analysis of the regulation of gene expression controlling physiological and pathological lipid accumulation

2014 Fiscal Year Final Research Report

• Project Area: Molecular Basis and Disorders of Control of Apetite and Fat Accumulation
• Project/Area Number: 22126011
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kobe University
• Principal Investigator: OGAWA WATARU 神戸大学, 医学(系)研究科(研究院), 教授 (40294219)
• Co-Investigator(Renkei-kenkyūsha): NOMURA Kazuhiro 神戸大学, 医学部附属病院, 医員 (70450236)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 肥満 / 異所性脂肪蓄積

Outline of Final Research Achievements

Obesity and exaggerated lipid accumulation in organs serve as the pathological basis of various diseases. In this study, we have aimed to identify novel regulatory mechanisms for physiological and pathological lipid accumulation of various organs We have found that the Stra13/SREBP1c transcriptional cascade as well as the mTORC1/S6K1signaling pathway play important role in the regulation of hepatic lipid accumulation and pathogenesis of fatty liver. We also found that impaired function of adipocytes resulted in the development of fatty liver diseases and NASH. Moreover, we have found that novel isoforms of the transcriptional coactivator PGC-1α regulate the accumulation of lipid through the control of the function of brown adipose tissue.

Free Research Field

代謝学