Molecular mechanism for self-renewal of cancer stem cells

2014 Fiscal Year Final Research Report

• Project Area: Development of Novel Treatment Strategies Targeting Cancer Stem Cells
• Project/Area Number: 22130006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Cancer Center Japan
• Principal Investigator: KITABAYASHI Issay 独立行政法人国立がん研究センター, 研究所, 分野長 (20261175)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 白血病 / がん幹細胞 / 分子標的治療

Outline of Final Research Achievements

Expression of M-CSFR, HOXA9 and c-KIT is high in stem cells of acute myeloid leukemia (AML). MOZ-fusions induce expression of these genes by interacting with PU.1, c-MYB and BRPF1, respectively, and that these pathways are critical for maintenance of AML stem cells. These finding indicate that the identified pathways can be therapeutic targets for AML.

Free Research Field

分子腫瘍学