Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Expression of M-CSFR, HOXA9 and c-KIT is high in stem cells of acute myeloid leukemia (AML). MOZ-fusions induce expression of these genes by interacting with PU.1, c-MYB and BRPF1, respectively, and that these pathways are critical for maintenance of AML stem cells. These finding indicate that the identified pathways can be therapeutic targets for AML.
Attribution of KAKENHI