Immunogenetic factor responsible to GvH reaction and/or GvL reaction.

2014 Fiscal Year Final Research Report

• Project Area: HLA polymorphism, disease and evolution
• Project/Area Number: 22133011
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: MORISHIMA Yasuo 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (20220056)
• Co-Investigator(Kenkyū-buntansha): MORISHIMA Satoko 藤田保健衛生大学, 医学部, 講師 (40463195)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ＧＶＨＤ / ＧＶＬ効果 / ＨＬＡ

Outline of Final Research Achievements

Hematopoietic stem cell transplantation induces specific immunological reactions. Donor-derived immune cells attack patient tissues resulting in graft-versus-host disease (GVHD), and do patient leukemia cells in graft-versus-leukemia (GVL) effect. This study focused on these GVHD and GVL effect using large cohort of unrelated donor transplant with HLA data and clinical data. Refined immuno-genetic methods elucidated that the diversity of HLA antigen and their conservative segment of HLA region induces ordered degree of GVHD and GVL effect. These findings is important not only for clinical transplant but also for understanding the mechanism of transplant-related immunological reaction and auto-immune reaction.

Free Research Field

血液内科学