Elucidation of the regulatory network involving non-coding RNAs in human cancers

2014 Fiscal Year Final Research Report

• Project Area: Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
• Project/Area Number: 22134005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Nagoya University
• Principal Investigator: TAKAHASHI Takashi 名古屋大学, 医学(系)研究科(研究院), 教授 (50231395)
• Co-Investigator(Kenkyū-buntansha): OSADA Hirotaka 愛知県がんセンター研究所, 分子腫瘍学部, 室長 (30204176)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 肺がん / ノンコーディングRNA / マイクロRNA / ネットワーク / パスウェイ

Outline of Final Research Achievements

We have taken an integrative approach between cancer biology and systems biology using supercomputer in order to dissect the molecular pathogenesis of human lung cancers, with the emphasis on the involvement of non-coding RNAs (ncRNAs) such as microRNAs and long non-coding RNAs. We have consequently succeeded in identifying multiple ncRNAs involved in this devastating cancer, which included miR-375, miR-30c, miR-342-3p, and a novel lncRNA, MYMLR.

Free Research Field

分子腫瘍学