2014 Fiscal Year Final Research Report
Development of synthetic methodology to supply materials for understanding of physiological system
Project Area | Establishment of Integrative Multi-level Systems Biology and its Applications |
Project/Area Number |
22136006
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Complex systems
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Research Institution | Osaka University |
Principal Investigator |
HARI Yoshiyuki 大阪大学, 薬学研究科(研究院), 准教授 (50347423)
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Co-Investigator(Kenkyū-buntansha) |
YOSHIMITSU Takehiko 大阪大学, 大学院薬学研究科, 准教授 (30301576)
KODAMA Tetsuya 大阪大学, 大学院薬学研究科, 助教 (00432443)
KOJIMA Naoto 大阪大学, 大学院薬学研究科, 助教 (90420413)
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Project Period (FY) |
2010-04-01 – 2015-03-31
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Keywords | 有機化学 |
Outline of Final Research Achievements |
For understanding of physiological system, it is essential to validate in silico physiological and pathological platform by biological experiments. The following two themes in this 5-year project were carried out; (i) the development of new synthetic methods capable of efficiently producing chemical compounds and (ii) the supply of chemical compounds utilized in biological experiments to validate the platform. During this project, we succeeded in developing a number of new synthetic methods applicable to an easy access to chemical compounds with unique skeletons as well as the synthesis of the derivatives with structural variations. In addition, collaborative researches with many groups in the project “HD physiology” were performed through the supply of the chemical compounds synthesized by us. These results could not only contribute to the progress of the “HD physiology” project but also give practical and useful information for drug-discovery research.
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Free Research Field |
生物有機化学、有機化学
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