2015 Fiscal Year Final Research Report
Creation of Innovative Organocatalysts Using the Network of Intermolecular Interactions
| Project Area | Advanced Molecular Transformations by Organocatalysts |
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| Project/Area Number |
23105007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYABE Hideto 兵庫医療大学, 薬学部, 教授 (10289035)
KOBAYASHI Yusuke 京都大学, 大学院薬学研究科, 助教 (90509275)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 有機触媒 / 不斉反応 / 水素結合 / ハロゲン結合 / ルイス塩基 / ルイス酸 / 天然物合成 / 複素環化学 |
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| Outline of Final Research Achievements |
With an aim of developing innovative organocatalysts, we designed new organocatalysts bearin a Lewis base or Lewis acid moiety such as aminothioureas, benzothiadiazines, NHC’s, phosphoric acids, halogen-bond donors. After many screening of these catalysts, a wide range of asymmetric reactions have been developed: (1) bifunctional aminothioureas (Neber reaction and aldol reaction), (2) benzothiadiazines (epoxidation, synthesis of allenoates, oxa-Michael addition), (3) TEMPO-promoted aerobic oxidation, (4) NHC-catalysts (thioesterification, synthesis of 3,3-disubstituted indoline-2-thiones), (5) phosphoric acids (anti-α,β-diamino acid derivatives), (6) halogen-bond donor catalysts (semi-pinacol rearrangement, direct dehydroxylative coupling reaction of alcohols with organosilanes), (7) arylboronic acids (hetero-Michael addition to α,β-unsaturated carboxylic acids), (8) total synthesis of nakadomarin A, caprazamycin A, and beraprost.
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| Free Research Field |
化学系薬学
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