2015 Fiscal Year Final Research Report
Regioselective Functionalization by Organocatalysis
| Project Area | Advanced Molecular Transformations by Organocatalysts |
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| Project/Area Number |
23105008
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 有機分子触媒 / 位置選択性 / アシル化 / 配糖体天然物 / 晩期官能基化 / 超分子キラリティー / 遠隔位不斉誘導 / 触媒制御 |
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| Outline of Final Research Achievements |
Regioselective manipulation of one of the multiple hydroxy groups of polyols such as carbohydrates has been a fundamental challenge in current organic synthesis. We have developed the following conventionally difficult molecular transformations; (1) total Synthesis of natural glycosides via catalytic regioselective acylation of carbohydrates, (2) organocatalytic late-stage functionalization of a natural cardiac glycoside, lanatoside C, (3) chemoselective oxidation by electronically tuned nitroxyl radical catalysts, (4) asymmetric desymmetrization of σ－symmetric linear diols, (5) kinetic resolution of a topologically chiral racemic rotaxane, (6) catalyst-controlled regiodivergent vinylogous aza-Morita-Baylis-Hillman reactions.
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| Free Research Field |
有機分子触媒
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